[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637353":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":61,"collaborators":26,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":26,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":26,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ultrasound-Guided Injection","EXPERIMENTAL","Participants receive a selective lumbar nerve root injection under real-time ultrasound guidance. The injectate consists of a 3 mL total volume (1 mL dexamethasone 4 mg, 1 mL 2% lidocaine, and 1 mL 0.9% sodium chloride). No contrast agent is used.",[13],"Procedure: Ultrasound-Guided Selective Lumbar Nerve Root Injection",{"label":15,"type":16,"description":17,"interventionNames":18},"Fluoroscopy-Guided Injection","ACTIVE_COMPARATOR","Participants receive a selective lumbar nerve root injection under fluoroscopic guidance. Iodinated contrast material is injected to confirm placement, followed by the therapeutic injectate consisting of a 3 mL total volume (1 mL dexamethasone 4 mg, 1 mL 2% lidocaine, and 1 mL 0.9% sodium chloride).",[19],"Procedure: Fluoroscopy-Guided Selective Lumbar Nerve Root Injection",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Ultrasound-Guided Selective Lumbar Nerve Root Injection","A posterior paravertebral ultrasound scan is performed using a curved transducer, followed by a transverse sonogram at the target site to identify the spinous process, vertebral lamina, facet joints, and intervertebral foramen. A 22-gauge spinal needle is advanced using an in-plane technique until mild paresthesia in the affected dermatome is elicited. The standardized therapeutic medication is then injected without the use of a contrast agent.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Fluoroscopy-Guided Selective Lumbar Nerve Root Injection","A C-arm fluoroscopy unit is used for visualization. A 22-gauge spinal needle is inserted into the safe triangle near the nerve root under fluoroscopic guidance. Iodinated contrast material (iohexol 240 mgI\u002FmL, 1-2 mL) is injected to confirm extra-vasculature, extra-thecal needle placement and to rule out intravascular injection before the standardized therapeutic medication is administered.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Ahmed S Alkotami, MD","CONTACT","+201008928948","ahmed.sami@med.tanta.edu.eg",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Faculty of Medicine, Tanta University.","RECRUITING","Tanta","Gharbia Governorate","31527","Egypt","EG",{"type":47,"coordinates":48},"Point",[49,50],31.00192,30.78847,{"lat":50,"lon":49},[53,54,57,59],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"name":55,"role":56,"phone":26,"phoneExt":26,"email":26},"Basem H Fouda, MD","PRINCIPAL_INVESTIGATOR",{"name":58,"role":56,"phone":26,"phoneExt":26,"email":26},"Wafaa M Abdelwahed, MD",{"name":60,"role":56,"phone":26,"phoneExt":26,"email":26},"Elsayed E Negm, MD",{"type":56,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ahmed Sami Alkotami","Lecturer of Neurology","100637353","us-vs-fl-guided-lumbar-nerve-root-injections-100637353",false,"NCT07627308","US vs FL-Guided Lumbar Nerve Root Injections","Ultrasound-Guided Versus Fluoroscopy-Guided Selective Lumbar Nerve Root Injections for Lumbosacral Radiculopathy: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 to 75 years.\n* Clinical diagnosis of lumbar radiculopathy characterized by radicular pain, paresthesia, or weakness in a dermatomal distribution.\n* Magnetic Resonance Imaging (MRI)-confirmed nerve root compression due to disc herniation or foraminal stenosis.\n* Failure to respond to at least 3 months of conservative medical treatment.\n* Radiculopathy affecting the L4, L5, or combined L5-S1 levels (where the primary symptomatic level can be reliably targeted)\n\nExclusion Criteria:\n\n* Isolated S1 radiculopathy.\n* Significant spinal deformities, including scoliosis \\>20° or spondylolisthesis \\>Grade II.\n* History of prior lumbar spine surgery.\n* Bleeding disorders (International Normalized Ratio \\[INR\\] \\>2.5).\n* Severe uncontrolled diabetes mellitus (HbA1c \\>8%).\n* Advanced cardiac, renal, or hepatic disease.\n* Active systemic infection or localized infection at the injection site.\n* Known allergies to corticosteroids or local anesthetics.\n* Presence of progressive neurological deficits or cauda equina syndrome.\n* Peripheral neuropathies mimicking radiculopathy.\n* Pregnancy or breastfeeding.\n* Severe psychiatric illness or cognitive impairment affecting study compliance.","ALL","18 Years","75 Years",{"count":75,"type":76},64,"ESTIMATED","INTERVENTIONAL",[79],"NA","The goal of this clinical trial is to learn if ultrasound-guided nerve root injections work as well as fluoroscopy (X-ray)-guided injections to treat lower back and leg pain caused by irritated nerves (lumbosacral radiculopathy) in adults aged 18 to 75 years old.\n\nThe main questions it aims to answer are:\n\n* Does ultrasound guidance lower pain as effectively as fluoroscopy guidance after 3 months?\n* Does one method help participants recover their ability to do daily activities better than the other?\n* Are ultrasound-guided injections as fast and safe for participants as fluoroscopy-guided injections? Researchers will compare ultrasound-guided nerve root injections to fluoroscopy-guided nerve root injections to see if ultrasound works to treat the pain just as well while allowing participants to avoid radiation exposure.\n\nParticipants will:\n\n* Receive one targeted nerve injection of medication (a steroid and numbing medicine) in their lower back using either ultrasound or fluoroscopy to guide the needle.\n* Stay at the clinic for 30 to 60 minutes after the procedure so researchers can check their safety.\n* Attend checkups at 1 week, 1 month, and 3 months to answer survey questions about their pain levels and daily functioning.",[82],"Lumbosacral Radiculopathy",[82,84,85,86],"Radicular Pain","Ultrasound-Guided","Fluoroscopy-Guided","2026-05-31",{"date":89,"type":90},"2026-06-04","ACTUAL",{"date":92,"type":90},"2026-06-01",{"date":94,"type":76},"2026-10-30",{"name":5,"class":6},1]