[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100480892":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":35,"locations":43,"responsibleParty":61,"collaborators":30,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":30,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":30,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":30,"overallStatus":46,"whyStopped":30,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Florida","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention-Placebo","ACTIVE_COMPARATOR","Participants in this arm will consume muscadine wine polyphenol for six weeks and then placebo for another six weeks. The two phases are separated by a 21-day washout period",[13,14],"Other: Muscadine Wine Polyphenol","Other: Placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"Placebo-Intervention","Participants in this arm will first consume placebo for six weeks and then muscadine wine polyphenol for another six weeks. The two phases are separated by a 21-day washout period",[13,14],[20,26],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Muscadine Wine Polyphenol","dealcoholized muscadine wine with alcohol content \\\u003C0.5% with addition of 50ppm of sodium metabisulfite for preservation",[9,16],[25],"Dealcoholized Muscadine Wine",{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Placebo","this placebo beverage is formulated with matching sugar and organic acid content to the muscadine wine polyphenol. Food coloring is added to match the color of the intervention. 50ppm of sodium metabisulfite for preservation",[9,16],null,[32],{"name":33,"affiliation":5,"role":34},"Liwei Gu, PhD","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},"Kylee Mai","CONTACT","479-203-8170","cmai1@ufl.edu",{"name":33,"role":38,"phone":30,"phoneExt":30,"email":42},"Lgu@ufl.edu",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Food Science and human nutrition department at University of Florida","RECRUITING","Gainesville","Florida","32611","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-82.32483,29.65163,{"lat":56,"lon":55},[59,60],{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},{"name":33,"role":38,"phone":30,"phoneExt":30,"email":42},{"type":62,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100480892","use-muscadine-wine-nutraceuticals-to-improve-brain-health-cognition-and-mental-health-100480892",false,"NCT05541887","Use Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental Health","Acute and Chronic Impacts of Muscadine Wine Polyphenols on Cognition, Memory, Mood, and Anxiety in Adults Over 50 Years of Age","Inclusion Criteria:\n\n* Healthy\n* BMI (18.5-29.9)\n* Body weight ≥110 pounds\n\nExclusion Criteria:\n\n* Pregnancy\n* Breast-feeding\n* Smokers\n* Diabetic\n* Heavy drinkers\n* Subjective but not clinically diagnosed cognitive impairment (Montreal cognitive assessment score \\\u003C26),\n* Inability to understand the cognitive function tasks\n* Intake of medication that might influence the outcome of the study (e.g. psychostimulant)\n* cannabis product user\n* Clinically diagnosed mental illnesses\n* Cardiovascular and neurological disorders\n* Uncontrolled hypertension",true,"ALL","50 Years","65 Years",{"count":75,"type":76},25,"ESTIMATED","INTERVENTIONAL",[79],"NA","Previous studies have shown that polyphenol-rich foods can positively affect cognitive functions, memory, and mood in humans. We hypothesize that both acute and chronic intake of muscadine wine polyphenols will improve cognitive performance and mood through regulating the HPA axis, alleviating inflammation and oxidative stress, and\u002For inhibiting monoamine oxidase activities",[82,83,84,85],"Cognitive Performance","Memory","Mood","Anxiety","2025-06-09",{"date":88,"type":89},"2025-06-12","ACTUAL",{"date":91,"type":89},"2023-08-30",{"date":93,"type":76},"2026-12",{"name":5,"class":6},1]