[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642131":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":34,"responsibleParty":52,"collaborators":55,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":20,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":20,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":37,"whyStopped":20,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Boston University Charles River Campus","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Effects of RAS on gait quality on brain activity in individuals with and without AD","EXPERIMENTAL","Participants will complete overground walking assessments with and without rhythmic auditory stimulation (RAS) under varying sensorimotor conditions while gait and cortical activity are measured using wearable sensors (IMUs) and portable neuroimaging (fNIRS).",[13],"Device: Metronome",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Metronome","Rhythmic Auditory stimulation",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Louis N Awad, PT, DPT, PhD","Boston University","PRINCIPAL_INVESTIGATOR",[27,32],{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},"Regina Sloutsky, PT, DPT, PhD","CONTACT","617-500-3645","reginas@bu.edu",{"name":23,"role":29,"phone":30,"phoneExt":20,"email":33},"louawad@bu.edu",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Boston University Neuromotor Recovery Laboratory","RECRUITING","Boston","Massachusetts","02215","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-71.05977,42.35843,{"lat":47,"lon":46},[50],{"name":23,"role":29,"phone":30,"phoneExt":20,"email":51},"gaitlab@bu.edu",{"type":25,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Lou Awad, PT, DPT, PhD","Associate Professor",[56],{"name":57,"class":58},"National Institute on Aging (NIA)","NIH","100642131","use-of-a-mobile-brain-body-imaging-approach-to-evaluate-the-effects-of-rhythmic-auditory-stimulation-on-gait-and-brain-function-in-alzheimers-disease-100642131",false,"NCT07659964","Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease","Inclusion Criteria:\n\nGeneral Inclusion (both healthy and AD populations):\n\n* Community-dwelling\n* Capable of walking short community distances (approximately 10-15 minutes at a time) without assistance from another person or a device (such as a cane).\n* Able to communicate with researchers\n* Age 50-90 (inclusive)\n\nPopulation-specific Inclusion criteria:\n\n* Healthy -\n\n  * No diagnosis of AD\n* AD population-\n\nCERAD score of \\\u003C1.5 SD from age + education adjusted norms on delayed recall domain or one or more other cognitive domains (i.e. language, attention).\n\nMoCA score between 20-30 MMSE score between 25-30\n\nExclusion Criteria:\n\n* Presence of significant hearing impairment\n* Current orthopedic, neurologic or other medical condition that limits the ability to walk.\n\nThe MOCA, MMSE and CERAD tests will be completed in-person after the participant consents into the study. If the participant is determined to be ineligible based on their performance on these tests (compared to inclusion requirements listed above), they will be informed that they are not eligible for this study and the study visit will be cancelled. They will then be withdrawn from the study; their clinical tests and study documentation will be maintained for the purposes of completeness, but will not be used for any study analyses.",true,"ALL","50 Years","90 Years",{"count":70,"type":71},40,"ESTIMATED","INTERVENTIONAL",[74],"NA","Alzheimer's Disease (AD) is associated with impairments in both gait and cognition, significantly increasing fall risk. Falls are a leading cause of injury-related disability in older adults, and individuals with AD experience a nearly threefold higher rate of falls compared to neurotypical older adults. There is an urgent need for fall prevention interventions tailored to the unique deficits of individuals with AD. Converging evidence suggests that interventions aiming to reduce fall risk in AD should target both gait and cognition. Rhythmic music interventions, such as Rhythmic Auditory Stimulation (RAS) can harness global brain activation and auditory-motor entrainment to facilitate high-intensity exercise to alleviate AD-related neurocognitive and gait dysfunction. This study aims to assess the neural correlates of gait dysfunction in people with AD, evaluate if baseline neurocognitive impairment is predictive of the effects of RAS, and evaluate RAS benefits for individuals with AD.",[77,78],"Alzheimer Disease (AD)","Mild Cognitive Impairment (MCI)",[80],"RAS","2026-06-17",{"date":83,"type":84},"2026-06-22","ACTUAL",{"date":86,"type":84},"2026-06-01",{"date":88,"type":71},"2027-06",{"name":5,"class":6},1]