[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601396":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":31,"locations":42,"responsibleParty":60,"collaborators":36,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":36,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":36,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":36,"overallStatus":45,"whyStopped":36,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Aswan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: letrozole and Misoprostol","ACTIVE_COMPARATOR","About 35 pregnant women will receive aromatase inhibitor (letrozole) 2.5 mg tablet three times daily for 3 days followed by two doses of 400 micrograms of misoprostol administered vaginally on the 4th day of enrolment (two 200-μg tablets spaced 4 hours apart).",[13],"Drug: Letrozole 2.5mg",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B: Misoprostol","About 35 pregnant women will receive two doses of 400 µg of vaginal misoprostol (two 200-μg tablets spaced 4 hours apart).",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Letrozole 2.5mg","to determine the effect of Letrozole as a premedication before misoprostol treatment used to induce missed miscarriage.",[9,15],[25],"Misoprestol",[27],{"name":28,"affiliation":29,"role":30},"Hani Ahmed Farouk, Assist.Prof.","Obstetrics and Gynecology,Faculty of Medicine,Aswan University","STUDY_CHAIR",[32,38],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Arwa Ashraf Saeed, MSC","CONTACT","+201013302339",null,"Arwa170439@aswu.edu.eg",{"name":39,"role":34,"phone":40,"phoneExt":36,"email":41},"Hani Ahmed Farouk, Assist.prof","+201112501460","hany.farouk@aswu.edu.eg",[43],{"facility":44,"status":45,"city":46,"state":36,"zip":36,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Aswan University Hospital","RECRUITING","Aswān","Egypt","EG",{"type":50,"coordinates":51},"Point",[52,53],32.89942,24.09082,{"lat":53,"lon":52},[56],{"name":57,"role":34,"phone":58,"phoneExt":36,"email":59},"Amr Shahata Abd Elbadee, Assist.Prof","+201007221659","Love_like902@yahoo.com",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"PRINCIPAL_INVESTIGATOR","Arwa Ashraf Saeed","Demonstrator at Obstetrics and Gynecology, Faculty of medicine","100601396","use-of-aromatase-inhibitor-before-misoprostol-in-medical-termination-of-miscarriage-100601396",false,"NCT07109947","Use of Aromatase Inhibitor Before Misoprostol in Medical Termination of Miscarriage","Comparison Between the Use of Aromatase Inhibitor Before Misoprostol and Use of Misoprostol Alone in Medical Termination of Miscarriage","Inclusion Criteria:\n\n* Missed or anembryonic pregnancy.\n* Gestational age from 4 weeks to 26 weeks of pregnancy (confirmed by ultrasound scanning on first day of admittance).\n* Hemoglobin level more than 9g\u002Fl.\n* Closed cervix.\n* No product of conception in the cervical canal.\n\nExclusion Criteria:\n\n* Previous attempt to terminate the pregnancy.\n* Molar pregnancy\n* Abnormal uterine lesions such as fibroids or congenital mal formations.\n* Pregnancy despite of intrauterine contraceptive device.\n* Medical disorders as cardiac, renal or hemorrhagic diseases.\n* BMI more than 35 kg\u002Fm2.\n* Known hypersensitivity to any of the medication used.","FEMALE","18 Years","45 Years",{"count":75,"type":76},70,"ESTIMATED","INTERVENTIONAL",[79],"NA","Abortion is one of the most common complications of pregnancy. Missed abortion is a type of abortions, occurs in 15%-20% of clinically diagnosed pregnancies and is defined as the retention of pregnancy products in the uterus for several days or weeks after death of the fetus.",[82],"Miscarriage","2025-07-31",{"date":85,"type":86},"2025-08-07","ACTUAL",{"date":88,"type":86},"2025-07-10",{"date":90,"type":76},"2025-12-10",{"name":5,"class":6},1]