[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590268":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":25,"responsibleParty":29,"collaborators":25,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":25,"eligibilityCriteria":37,"healthyVolunteers":33,"sex":38,"minAge":39,"maxAge":25,"enrollmentInfo":40,"targetDuration":25,"studyType":43,"phases":44,"briefSummary":46,"conditions":47,"keywords":49,"overallStatus":53,"whyStopped":25,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":25},{"fullName":5,"class":6},"Royal College of Surgeons, Ireland","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard feeds","ACTIVE_COMPARATOR","Standard feeds will be with Nutrison Protein Plus 1.25kcal\u002Fml.\n\n* Day 1: if no clinical contra-indication, commence feeding either with standard or MCT feeds at 20ml\u002Fhr for 24 hours. Feeds to commence at 8am.\n* Day 2: if tolerating feeds continue feeds at 20ml\u002Fhr for 12 hours, then increase to 40ml\u002Fhr for 12 hours\n* Day 3: if tolerating feeds increase feeds to 60ml\u002Fhr and await dietician review regarding target rate and duration.\n\nFor oral feeding, if patients are progressing clinically, they will have restricted fluids on POD3, with introduction of diet in each group from day 4 onwards. This allows a direct comparison of chyle leak rates for 72h of regular vs MCT enteral feeding.",[13],"Dietary Supplement: Standard feeds",{"label":15,"type":16,"description":17,"interventionNames":18},"MCT feeds","EXPERIMENTAL","MCT feeds will be initiated using Nutrison Peptisorb 1kcal\u002Fml. Peptisorb has lower fat content, with a higher proportion of MCTs. The feeding protocol for both formulae will be the same, with equivalent rates of enteral feeding:\n\n* Day 1: if no clinical contra-indication, commence feeding either with standard or MCT feeds at 20ml\u002Fhr for 24 hours. Feeds to commence at 8am.\n* Day 2: if tolerating feeds continue feeds at 20ml\u002Fhr for 12 hours, then increase to 40ml\u002Fhr for 12 hours\n* Day 3: if tolerating feeds increase feeds to 60ml\u002Fhr and await dietician review regarding target rate and duration.\n\nBy POD6, if there is no chyle leak, all patients will be given standard feeds for discharge home.\n\nFor oral feeding, if patients are progressing clinically, they will have restricted fluids on POD3, with introduction of diet in each group from day 4 onwards. This allows a direct comparison of chyle leak rates for 72h of regular vs MCT enteral feeding.",[19],"Dietary Supplement: MCT feeding",[21,26],{"type":22,"name":23,"description":17,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","MCT feeding",[15],null,{"type":22,"name":9,"description":27,"armGroupLabels":28,"otherNames":25},"Nutrison Protein Plus 1.25kcal\u002Fml.",[9],{"type":30,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100590268","use-of-different-enteral-feeds-to-impact-on-chyle-leaks-in-oesophagectomy-100590268",false,"NCT06965205","Use of Different Enteral Feeds to Impact on Chyle Leaks in Oesophagectomy","Impact of Enteral Feeding Approaches on Chyle Leaks in Oesophageal Cancer Surgery","Inclusion Criteria:\n\n* All adults aged over 18 years undergoing MIO or RAMIO for oesophageal cancer (adenocarcinoma and squamous cell cancer) at Beaumont Hospital will be approached for inclusion.\n\nExclusion Criteria:\n\n* Patients will be excluded if\n\n  * They are unable to provide informed consent\n  * They do not receive a feeding jejunostomy at or prior to their oesophagectomy\n  * Prior or concomitant malignancy that would interfere with this protocol","ALL","18 Years",{"count":41,"type":42},160,"ESTIMATED","INTERVENTIONAL",[45],"NA","Oesophagectomy (surgery to remove a cancerous portion of the oesophagus or gullet) is the cornerstone of treating oesophageal cancer. In recent years, minimally invasive techniques, including robotic assisted oesophagectomy have been introduced. These techniques reduce stress on patients, reduce pain, reduce the length of stay in hospital after their operation, without compromising cancer outcomes (and in some cases improving cancer outcomes). Any surgery carries the risk of complications. One complication that may arise with oesophagectomy is an increase in chyle leaks. Chyle is a fluid produced by the body that helps transport nutrients from the bowel to the bloodstream to allow them to be absorbed and processed. One of the channels that transports chyle, the thoracic duct, is divided as part of an oesophagectomy. Although it is clipped to reduce the risk of chyle leak, this may still occur, in up to 25% of operations. If a chyle leak occurs, a drainage tube needs to remain in the chest for a number of days, there may be alterations in the use of feeding techniques, and in a small portion of cases, there may need to be an operation to stop a leak, or a procedure in the radiology department. The goal of this study is to see whether use of a different type of post-operative feed (medium chain triglyceride or MCT feeds) can reduce the rate of chyle leak. This is already used\n\nto treat chyle leaks, and the question is whether using this as the routine post-operative feed can reduce rates of chyle leakage.",[48],"Oesophageal Cancer",[50,51,52],"Oesophageal cancer","chyle leak","MCT feed","NOT_YET_RECRUITING","2025-05-01",{"date":56,"type":57},"2025-05-11","ACTUAL",{"date":59,"type":42},"2025-05-05",{"date":61,"type":42},"2030-12-31",{"name":5,"class":6}]