[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548773":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":7,"locations":13,"responsibleParty":36,"collaborators":7,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":42,"acronym":7,"eligibilityCriteria":43,"healthyVolunteers":40,"sex":44,"minAge":45,"maxAge":7,"enrollmentInfo":46,"targetDuration":7,"studyType":49,"phases":7,"briefSummary":50,"conditions":51,"keywords":7,"overallStatus":16,"whyStopped":7,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":62},{"fullName":5,"class":6},"University of Roma La Sapienza","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DEVICE","Mechanical ventilation","Mechanical ventilatiom",[14],{"facility":15,"status":16,"city":17,"state":7,"zip":18,"country":19,"countryCode":20,"cosmosGeoPoint":21,"geoPoint":26,"contacts":27},"Sapienza University of Rome","RECRUITING","Roma","00161","Italy","IT",{"type":22,"coordinates":23},"Point",[24,25],11.10642,44.99364,{"lat":25,"lon":24},[28,33],{"name":29,"role":30,"phone":31,"phoneExt":7,"email":32},"Francesco Alessandri","CONTACT","0039 0649978924","f.alessandri@uniroma1.it",{"name":34,"role":35,"phone":7,"phoneExt":7,"email":7},"Giovanni Giordano","PRINCIPAL_INVESTIGATOR",{"type":35,"investigatorFullName":29,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Prof","100548773","use-of-mechanical-power-as-a-predictor-of-increased-serum-and-pulmonary-proinflammatory-cytokine-concentrations-in-patients-with-acute-hypoxemic-respiratory-failure-a-prospective-observational-study-100548773",false,"NCT06425354","Use of 'Mechanical Power' as a Predictor of Increased Serum and Pulmonary Proinflammatory Cytokine Concentrations in Patients With Acute Hypoxemic Respiratory Failure: A Prospective Observational Study","Inclusion Criteria:\n\n* Patients with AHRF (P\u002FF \\\u003C300 mmHg) undergoing invasive mechanical ventilation within 7 days from the onset of symptoms\n* Invasive mechanical ventilation for less than 6 hours\n* Evidence of newly developed lung consolidation on chest imaging (X-ray, CT)\n* Age ≥18 years\n\nExclusion Criteria:\n\n* Prior invasive mechanical ventilation during the same hospitalization\n* Tracheostomy\n* Severe anemia (Hb\\\u003C7g\u002FdL)\n* Severe neutropenia\n* Renal insufficiency or RRT (Renal Replacement Therapy)\n* Noradrenaline \\>0.5 mcg\u002Fkg\u002Fmin\n* Pregnancy\n* Extracorporeal circulation (ECCO2R, ECMO)\n* Life expectancy \\\u003C24 hours as clinically judged\n* Lack of consent","ALL","18 Years",{"count":47,"type":48},150,"ESTIMATED","OBSERVATIONAL","The aim of this study is to report the proportion of patients with acute hypoxemic respiratory failyre (AHRF) undergoing mechanical ventilation who exceed 17 J\u002Fmin of mechanical power (MP) and the difference in terms of proinflammatory cytokine concentration in blood samples and bronchoalveolar lavage.\n\nThe main questions it aims to answer are:\n\n1. Which is the proportion of patients who exceed 17 J\u002Fmin of mechanical power (MP) during the first 72 hours of mechanical ventilation?\n2. Is there a difference in terms of cytokine concentration in patients undergoing mechanical power \\>17 J\u002Fmin compared to \\\u003C17 J\u002Fmin?\n\nPatients will be divided into two groups based on respiratory mechanics measurements: low MP group (average MP \\\u003C17 J\u002Fmin) and high MP group (average MP ≥17 J\u002Fmin). The researchers will collect blood and BAL samples and perform cytokine assays.",[52],"Mechanical Power","2024-05-17",{"date":55,"type":56},"2024-05-22","ACTUAL",{"date":58,"type":56},"2023-04-15",{"date":60,"type":48},"2027-06-15",{"name":5,"class":6},1]