[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590712":3},{"organization":4,"armGroups":7,"interventions":44,"overallOfficials":66,"centralContacts":70,"locations":78,"responsibleParty":97,"collaborators":49,"id":101,"slug":102,"hasResults":103,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":49,"eligibilityCriteria":107,"healthyVolunteers":103,"sex":108,"minAge":109,"maxAge":49,"enrollmentInfo":110,"targetDuration":49,"studyType":113,"phases":114,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":81,"whyStopped":49,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":129,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"Capital Medical University","OTHER",[8,14,19,24,29,34,39],{"label":9,"type":10,"description":11,"interventionNames":12},"HFNC:flow=50L\u002Fmin","EXPERIMENTAL","Under high-flow oxygen therapy at a flow rate of 50 L\u002Fmin, record\u002Fmonitor for 5 minutes",[13],"Procedure: HFNC:50L\u002Fmin",{"label":15,"type":10,"description":16,"interventionNames":17},"HFNC:flow=40L\u002Fmin","Under high-flow oxygen therapy at a flow rate of 40 L\u002Fmin, record\u002Fmonitor for 5 minutes",[18],"Procedure: HFNC:flow=40L\u002Fmin",{"label":20,"type":10,"description":21,"interventionNames":22},"HFNC:flow=30L\u002Fmin","Under high-flow oxygen therapy at a flow rate of 30 L\u002Fmin, record\u002Fmonitor for 5 minutes",[23],"Procedure: HFNC:flow=30L\u002Fmin",{"label":25,"type":10,"description":26,"interventionNames":27},"Face Mask Oxygen:8L\u002Fmin","Under face mask oxygen at a flow rate of 8 L\u002Fmin, record\u002Fmonitor for 5 minutes.",[28],"Procedure: Face mask oxygen:8L\u002Fmin",{"label":30,"type":10,"description":31,"interventionNames":32},"Face Mask Oxygen:5L\u002Fmin","Under face mask oxygen at a flow rate of 5 L\u002Fmin, record\u002Fmonitor for 5 minutes.",[33],"Procedure: Face mask oxygen:5L\u002Fmin",{"label":35,"type":10,"description":36,"interventionNames":37},"Nasal cannula oxygen:5L\u002Fmin","Under nasal cannula oxygen at a flow rate of 5 L\u002Fmin, record\u002Fmonitor for 5 minutes.",[38],"Procedure: Nasal cannula oxygen:5L\u002Fmin",{"label":40,"type":10,"description":41,"interventionNames":42},"Nasal cannula oxygen:3L\u002Fmin","Under nasal cannula oxygen at a flow rate of 3 L\u002Fmin, record\u002Fmonitor for 5 minutes.",[43],"Procedure: Nasal cannula oxygen:3L\u002Fmin",[45,50,53,56,59,62,64],{"type":46,"name":47,"description":11,"armGroupLabels":48,"otherNames":49},"PROCEDURE","HFNC:50L\u002Fmin",[9],null,{"type":46,"name":15,"description":51,"armGroupLabels":52,"otherNames":49},"Under high-flow oxygen therapy at a flow rate of 40 L\u002Fmin, record\u002Fmonitor for 5 minutes.",[15],{"type":46,"name":20,"description":54,"armGroupLabels":55,"otherNames":49},"Under high-flow oxygen therapy at a flow rate of 30 L\u002Fmin, record\u002Fmonitor for 5 minutes.",[20],{"type":46,"name":57,"description":26,"armGroupLabels":58,"otherNames":49},"Face mask oxygen:8L\u002Fmin",[25],{"type":46,"name":60,"description":31,"armGroupLabels":61,"otherNames":49},"Face mask oxygen:5L\u002Fmin",[30],{"type":46,"name":35,"description":36,"armGroupLabels":63,"otherNames":49},[35],{"type":46,"name":40,"description":41,"armGroupLabels":65,"otherNames":49},[40],[67],{"name":68,"affiliation":5,"role":69},"Jian-Xin Zhou, MD, PhD","PRINCIPAL_INVESTIGATOR",[71,75],{"name":68,"role":72,"phone":73,"phoneExt":49,"email":74},"CONTACT","8610 6392 6666","zhoujx.cn@icloud.com",{"name":76,"role":72,"phone":49,"phoneExt":49,"email":77},"Rui-Zhi Zhang,MD","ifz0000@126.com",[79],{"facility":80,"status":81,"city":82,"state":83,"zip":84,"country":85,"countryCode":86,"cosmosGeoPoint":87,"geoPoint":92,"contacts":93},"Beijing Shijitan Hospital","RECRUITING","Beijing","Beijing Municipality","100038","China","CN",{"type":88,"coordinates":89},"Point",[90,91],116.39723,39.9075,{"lat":91,"lon":90},[94,96],{"name":68,"role":72,"phone":95,"phoneExt":49,"email":74},"+861063926666",{"name":76,"role":72,"phone":49,"phoneExt":49,"email":77},{"type":98,"investigatorFullName":99,"investigatorTitle":100,"investigatorAffiliation":5,"oldNameTitle":49,"oldOrganization":49},"SPONSOR_INVESTIGATOR","Jian-Xin Zhou","Head of Emergency and Critical Care Center","100590712","use-of-nasal-pressure-to-assess-inspiratory-effort-under-different-oxygen-treatments-100590712",false,"NCT06970990","Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments","Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments: a Prospective Physiological Study","Inclusion Criteria:\n\n1. No mechanical ventilation required,Able to tolerate oxygen therapy via nasal cannula, standard face mask, or nasal high-flow oxygen therapy;\n2. Respiratory stability:Capable of spontaneous breathing with effective cough for secretion clearance.Oxygen saturation (SpO₂) \\> 90% or PaO₂\u002FFiO₂ ≥ 150 mmHg when receiving nasal cannula oxygen at 3 L\u002Fmin;\n3. Hemodynamic stability:Heart rate (HR) ≤ 120 bpm;Systolic blood pressure (SBP) 90-150 mmHg;No vasoactive medications OR norepinephrine dosage \\\u003C 0.1-0.2 μg\u002Fkg·min (or equivalent doses of other vasoactive agents);\n4. Metabolic stability;\n5. Compliance with medical instructions.Able to follow prescribed tasks.Esophageal pressure monitoring catheter already in place;\n6. Patient or legal guardian agrees to participate and has signed the informed consent form.\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years;\n2. Pregnancy;\n3. Hemodynamic instability:Mean arterial pressure (MAP) \\\u003C 60 mmHg.Heart rate (HR) \\> 120 bpm or \\\u003C 60 bpm;\n4. Respiratory instability:Respiratory rate (RR) \\> 35 bpm.Oxygen saturation (SpO₂) \\\u003C 90%;\n5. Neuromuscular diseases or phrenic nerve injury;\n6. Recent trauma or surgery involving the trachea, esophagus, neck, or chest.Contraindications to esophageal catheter placement or inability to monitor esophageal pressure;\n7. Nasal obstruction or anatomical abnormalities:Complete nasal obstruction.Severe anatomical abnormalities (e.g., severe septal deviation, nasal polyps, or tumors) preventing catheter placement or compromising ventilation;\n8. High-risk craniofacial conditions:Severe facial trauma or skull base fracture with risk of catheter misplacement into the intracranial space.Active epistaxis or incomplete healing after nasal surgery;\n9. Bleeding risk:Severe coagulopathy.Esophageal\u002Fgastric varices or other conditions predisposing to hemorrhage.","ALL","18 Years",{"count":111,"type":112},26,"ESTIMATED","INTERVENTIONAL",[115],"NA","The aim of this study was to investigate the effects of different oxygen therapy modalities (including nasal cannula oxygen, mask oxygen and high-flow nasal cannula oxygen) on the correlation between Nasal Pressure and Esophageal Pressure by means of a prospective physiological study, to assess the dynamic changes of nasal pressure and esophageal pressure and their underlying mechanisms under different conditions of oxygen therapy, to analyse the effects of oxygen therapy parameters on the relationship between the two, and to explore the feasibility of nasal pressure as a non-invasive monitoring indicator, in order to replaceor supplement esophageal manometry in clinical practice, especially in patients with respiratory distress and instability.Meanwhile, this study will also evaluate the effects of different oxygen therapy modalities on patients' respiratory mechanics and comfort, provide a scientific basis for the clinical selection of individualised oxygen therapy regimens, and ultimately provide new physiological evidence for the management of oxygen therapy in patients with acute respiratory failure in the intensive care unit (ICU) and outside the ICU, promote the development of non-invasive monitoring technology, and improve the clinical prognosis and therapeutic experience of patients.",[118,119],"Critical Care","Inspiratory Effort",[121,122,123,124],"Esophageal pressure","inspiratory effort","oxygen treatments","Nasal Pressure","2025-05-20",{"date":127,"type":128},"2025-05-22","ACTUAL",{"date":125,"type":128},{"date":131,"type":112},"2025-12-30",{"name":99,"class":6},1]