[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620045":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":24,"responsibleParty":43,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":49,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"University of Palermo","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"PEA + Scutellaria + Therapeutic Exercise",null,"This group consists of patients who will receive a combination of palmitoylethanolamide (PEA) and Scutellaria along with a standardized therapeutic exercise regimen. The goal is to evaluate the synergistic effects of the nutraceuticals and exercise in reducing neuropathic pain and improving overall nerve health.",{"label":13,"type":10,"description":14,"interventionNames":10},"Therapeutic Exercise Only","Patients in this group will participate in a standardized therapeutic exercise program without any additional nutraceutical intervention. This cohort will help determine the efficacy of therapeutic exercise alone in managing symptoms of chemotherapy-induced peripheral neuropathy (CIPN).",{"label":16,"type":10,"description":17,"interventionNames":10},"PEA + Scutellaria Only","This group includes patients who will be treated with a combination of PEA and Scutellaria without participating in any structured exercise regimen. The aim is to assess the impact of the nutraceuticals alone on reducing neuropathic pain and improving nerve function.",[19],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Giulia Letizia Mauro","CONTACT","+39 0916554160 +39 09165541","giulia.letiziamauro@unipa.it",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"A.O.U.P. P. Giaccone, Palermo, Italia 90127","RECRUITING","Palermo","Italia","90127","Italy","IT",{"type":34,"coordinates":35},"Point",[36,37],13.3636,38.1166,{"lat":37,"lon":36},[40],{"name":41,"role":21,"phone":42,"phoneExt":10,"email":23},"Letizia Mauro Professor","00390916554160",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Prof.ssa Giulia Letizia Mauro","Professor","100620045","use-of-pea-and-scutellaria-in-synergy-with-therapeutic-exercise-in-chemotherapy-induced-peripheral-neuropathy-cipn-a-clinical-trial-100620045",false,"NCT07352514","Use of PEA and Scutellaria in Synergy With Therapeutic Exercise in Chemotherapy-induced Peripheral Neuropathy (CIPN): a Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 years and older.\n* Patients who have undergone chemotherapy treatment within the previous 6 months.\n* Patients treated with PEA, Scutellaria, and standardized therapeutic exercise according to the EXCAP protocol from April 2025 to September 2025.\n* Patients with a washout period from opioid-based analgesic therapy of at least 10 days or who are not receiving opioid-based analgesic therapy.\n* Patients presenting with neuropathic pain (NRS ≥ 5).\n* Patients able to provide written informed consent.\n\nExclusion Criteria:\n\n* Patients younger than 18 years.\n* Patients with hypersensitivity to PEA or any of the excipients listed in the Summary of Product Characteristics (SPC).\n* Patients with diabetic pathology.\n* Patients with severe hepatic impairment.\n* Patients with severe disabilities that compromise the execution of therapeutic exercise.","ALL","18 Years",{"count":56,"type":57},40,"ESTIMATED","OBSERVATIONAL","This study aims to find out if taking specific dietary supplements (PEA and Scutellaria) along with therapeutic exercise can help reduce nerve pain and damage caused by chemotherapy. Many cancer patients experience nerve-related side effects from chemotherapy, which can significantly impact their quality of life. The study will observe patients who use these supplements and exercises to see if they can effectively manage and improve their nerve health and reduce pain.",[61,62],"Chemotherapy-induced Peripheral Neuropathy (CIPN)","Neuropathic Pain",[64,62,65,66,67,68,69,70,71,72,73],"Chemotherapy-Induced Peripheral Neuropathy","Nutraceuticals","Palmitoylethanolamide","Scutellaria","Therapeutic Exercise","Cancer Patients","Pain Management","Neuropathy Treatment","Clinical Trial","Observational Case-Control Study","2026-01-13",{"date":76,"type":77},"2026-01-20","ACTUAL",{"date":79,"type":77},"2025-03-15",{"date":81,"type":57},"2026-04",{"name":5,"class":6},1]