[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606757":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":55,"collaborators":25,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":25,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Chulalongkorn University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HPI first","EXPERIMENTAL","Arm A: HPI-guided management during first PIRRT → standard care in second session",[13],"Device: Hypotensive prediction index",{"label":15,"type":10,"description":16,"interventionNames":17},"Standard of care first","Arm B: Standard care during first PIRRT → HPI-guided management in second session",[18],"Device: Standard of care monitoring",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Hypotensive prediction index","The HPI, developed by Edwards Lifesciences and integrated into the HemosphereⓇ hemodynamic monitoring system, is an algorithm-based tool that predicts hypotensive events before they occur, allowing earlier intervention. While this tool has shown benefit in surgical and post-operative settings, it has not been tested in ICU patients undergoing dialysis.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Standard of care monitoring","Standard of Care\n\n* Monitoring via conventional invasive BP and clinical judgment\n* Use of physical exam, CVP, PPV, and response-based decisions (fluid bolus, vasopressors)",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Nattapakorn Mai-on","CONTACT","66970051116","nattapakorn.m@gmail.com",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":39},"Nuttha Lumlertgul","66855788949","nlumlertgul@gmail.com",[41],{"facility":42,"status":43,"city":44,"state":25,"zip":25,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Division of Nephrology, Faculty of Medicine, Chulalongkorn University","RECRUITING","Bangkok","Thailand","TH",{"type":48,"coordinates":49},"Point",[50,51],100.50144,13.75398,{"lat":51,"lon":50},[54],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"type":56,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100606757","using-a-hypotension-prediction-index-to-prevent-low-blood-pressure-during-dialysis-in-icu-patients-100606757",false,"NCT07179705","Using a Hypotension Prediction Index to Prevent Low Blood Pressure During Dialysis in ICU Patients","Hypotension Prediction Index Guided Prevention of Intradialytic Hypotension During Intermittent Renal Replacement Therapy in Intensive Care Units","HyPIR-ICU","Inclusion Criteria:\n\n* Adults \\>18 years old\n* Diagnosed with acute kidney injury (AKI) or end-stage kidney disease (ESKD)\n* Admitted to medical ICU\n* Scheduled for PIRRT\n* Have an indwelling arterial catheter\n\nExclusion Criteria:\n\n* Severe right heart dysfunction, significant valvular disease, arrhythmias, mechanical circulatory support, absence of arterial access, no UF prescription, palliative care, or expected ICU stay \\\u003C72 hours.","ALL","18 Years",{"count":68,"type":69},46,"ESTIMATED","INTERVENTIONAL",[72],"NA","This single-center, crossover randomized controlled trial (HyPIR-ICU) investigates whether a Hypotension Prediction Index (HPI)-guided management strategy can reduce intradialytic hypotension (IDH) during prolonged intermittent renal replacement therapy (PIRRT) in critically ill patients. All participants must have an indwelling arterial catheter for continuous hemodynamic monitoring.",[75,76,77],"Intradialytic Hypotension","Intensive Care Unit ICU","Hemodialysis Patients",[79,80,81,82,83,84],"Hypotension Prediction Index (HPI)","Prolonged intermittent renal replacement therapy (PIRRT)","Slow-low efficiency dialysis","Intradialytic hypotension","Hemodynamic monitoring","Intensive Care Unit","2026-05-05",{"date":87,"type":88},"2026-05-07","ACTUAL",{"date":90,"type":88},"2025-10-10",{"date":92,"type":69},"2026-12-31",{"name":5,"class":6},1]