[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570048":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":63,"collaborators":26,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Institut De La Colonne Vertebrale Et Des Neurosciences","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Condition","ACTIVE_COMPARATOR","Active sessions will last 1 hour each. The following parameters will be used for electric stimulation: low frequency (20 Hz), low current intensity (2 mA), with a small pulse width of 25-170 microseconds. These parameters were previously found to be safe in human studies.",[13],"Device: EXOPULSE MOLLII SUIT active",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Condition","SHAM_COMPARATOR","The control arm will be a sham intervention. The patients will receive a sham stimulation, for which the same Exopulse Mollii suit will be used but the control unit will be programmed to start stimulating for 1 minute then it will shut off which could enable cutaneous sensations that mimic the active condition, aiming to achieve an effective blinding integrity. There is no risk related to the sham intervention since it consists of applying the same parameters used for the active session (low frequency: 20 Hz; current intensity: 2 mA; pulse width ranging from 25 to 170 µs) but for a shorter duration of time (1 minute).",[19],"Device: EXOPULSE MOLLII SUIT (sham)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","EXOPULSE MOLLII SUIT active","Exopulse Mollii suit is a new assistive device that has been developed by Exoneural Network (initially Inerventions AB), a Swedish med-tech company. Exopulse Mollii suit is a full-body garment with integrated 58 electrodes that can transcutaneously stimulate several groups of muscles. The device is CE labelled and is intended to use for reducing spasticity and improving blood circulation. The outfit is very easy to put on, it can be used for one hour every day and the analgesic effects last 24 hours or more. EXOPULSE Mollii suit consists of transcutaneous stimulation of several muscles by means of a feeble electric current (i.e., low frequency \\~20 Hz, low-intensity 2mA), aiming to reduce pain. This treatment method theoretical background primarily refers to the theory of gate control. Based on this theory, the stimulation of large proprioceptive fibers would inhibit the nociceptive information transmitted by small fibers.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"EXOPULSE MOLLII SUIT (sham)","It consists of applying the same parameters used for the active session (low frequency: 20 Hz; current intensity: 2 mA; pulse width ranging from 25 to 175 µs) but for a shorter duration of time (1 minute).",[15],[32],{"name":33,"affiliation":34,"role":35},"Samar S Ayache, MD, PhD, HDR","Hopital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Samar S AYACHE, MD, PhD, HDR","CONTACT","+33 149814662","samarayache@gmail.com",{"name":43,"role":39,"phone":26,"phoneExt":26,"email":44},"Moussa A CHALAH, MD,PhD","moussachalah@gmail.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"linical Neurophysiology department, Henri Mondor Hospital, Créteil, France","RECRUITING","Créteil","VAL DE MARNE","94000","France","FR",{"type":55,"coordinates":56},"Point",[57,58],2.46569,48.79266,{"lat":58,"lon":57},[61],{"name":62,"role":39,"phone":26,"phoneExt":26,"email":26},"Samar S AYACHE, MD,PhD",{"type":64,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100570048","using-a-multisite-tens-system-to-improve-fibromyalgia-related-symptoms-100570048",false,"NCT06702176","\"Using a Multisite TENS SysteM to Improve Fibromyalgia-related Symptoms.","\"Using a Multisite TENS System (Transcutaneous Electrical Noninvasive Stimulation) to Improve Fibromyalgia-related Symptoms (EXOFIB 3)\"","EXOFIB3","Inclusion Criteria:\n\n* Patients aged between 18 and 75 years, with a definite diagnosis of fibromyalgia according to the American College of Rheumatology (ACR) 2010 criteria, set for at least three months\n* Patients should be French speakers, able to understand verbal instructions, and affiliated with the National Health insurance\n\nExclusion Criteria:\n\n* Patient included in another research protocol during the study period\n* Patient unable to undergo medical monitoring for the study purposes due to geographical or social reasons\n* Patient with contraindication to wearing Exopulse Mollii suit (e.g., cardiac stimulator, a ventriculoperitoneal shunt, intrathecal baclofen pump, pregnancy, and\u002For body mass index above 35 kg\u002Fm2)\n* Patient with somatic or psychiatric diagnoses other than anxiety and depression (e.g., arrhythmias, uncontrolled epilepsy, other diseases causing osteoarticular and muscular pain)\n* Any change in the pharmacological therapy in the last three months\n* Introduction of a medical device other than Exopulse Mollii suit during the study period\n* Patient under juridical protection (\" mesure de protection judiciare : tutelle, curatelle, sauvegarde de justice \")","ALL","18 Years","75 Years",{"count":77,"type":78},40,"ESTIMATED","INTERVENTIONAL",[81],"NA","Fibromyalgia is a debilitating pain condition that is characterized by the chronic occurrence of pain affecting the musculoskeletal system, a sensitivity to pressure stimuli, and a low threshold to noxious stimuli. The topography of pain is widespread, although it could be more pronounced in some bodily regions. Besides pain, patients suffer from a wide range of symptoms, including fatigue, anxiety and depression manifestations, and altered quality of life. Facing these debilitating symptoms, the available therapeutic strategies for treating pain and associated manifestations are usually faced with limited efficacy and numerous side effects. A previous pilot trial on fibromyalgia (EXOFIB-1 study) was conducted to evaluate the effects of Exopulse Mollii suit on fibromyalgia has showed beneficial and promising results. The intervention significantly alleviated pain, reduced fatigue, decreased physical and psychosocial impact of the disease, and improved the quality of life of patients with fibromyalgia. However, the observed effect sizes were small to medium. The investigators believe that a stimulation duration extended to six months would yield more positive outcomes and higher effect magnitude.",[84],"Fibromyalgia, Pain",[86],"Exopulse Mollii Suit, Fibromyalgia","2024-11-20",{"date":89,"type":90},"2024-11-22","ACTUAL",{"date":92,"type":90},"2024-03-01",{"date":94,"type":78},"2026-06-30",{"name":5,"class":6},1]