[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613576":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":102,"collaborators":26,"id":104,"slug":105,"hasResults":106,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":26,"eligibilityCriteria":110,"healthyVolunteers":106,"sex":111,"minAge":112,"maxAge":26,"enrollmentInfo":113,"targetDuration":26,"studyType":116,"phases":117,"briefSummary":119,"conditions":120,"keywords":122,"overallStatus":128,"whyStopped":26,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":138},{"fullName":5,"class":6},"Instituto de Investigación Biomédica de Salamanca","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","ACTIVE_COMPARATOR","At the coordinating center (CAUSA), a control group (n = 20) will be included, consisting of patients with a clinical indication for cardiac CT for reasons other than myocardial infarction, meeting the following criteria: absence of myocardial injury or structural heart disease, ≤1 cardiovascular risk factor, LVEF \\> 55%, and no significant valvular disease (grade \\\u003C III).",[13],"Procedure: Blood analysis and spectral CT study",{"label":15,"type":16,"description":17,"interventionNames":18},"Adult patients experiencing a first ST-segment elevation myocardial infarction (STEMI)","EXPERIMENTAL","Patientes will be included in this group if the following requirements are met:\n\nHospital admission due to STEMI, treated in accordance with current clinical practice guidelines.\n\nLeft ventricular systolic dysfunction, defined as a left ventricular ejection fraction (LVEF) \\\u003C 50%, assessed by transthoracic echocardiography (TTE) within the first 24-72 hours of admission.\n\nProvision of signed informed consent.",[19],"Procedure: Blood analysis, spectral CT scan and cardiac magnetic resonance imaging (CMR) study",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Blood analysis, spectral CT scan and cardiac magnetic resonance imaging (CMR) study","After providing informed consent, patients will undergo blood sampling, a spectral CT scan scheduled between the 3rd and 7th day of hospitalization (acute phase), and a cardiac magnetic resonance imaging (CMR) study performed within a maximum of 72 hours from the CT.",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Blood analysis and spectral CT study","Patients who meet the inclusion criteria for the control group will be invited to participate in the study. They will undergo blood sampling and the planned spectral CT study, including a late iodine enhancement acquisition.",[9],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Candelas Pérez del Villar, MD in Cardiology","CONTACT","+34923291200","mcperezvi@saludcastillayleon.es",{"name":38,"role":34,"phone":35,"phoneExt":26,"email":39},"Beatriz Martín Carro, PhD","bmartincar.ibsal@saludcastillayleon.es",[41,57,67,77,89],{"facility":42,"status":26,"city":43,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Centro Nacional de Investigaciones Cardiovasculares (CNIC)","Madrid","Spain","ES",{"type":47,"coordinates":48},"Point",[49,50],-3.70256,40.4165,{"lat":50,"lon":49},[53],{"name":54,"role":34,"phone":55,"phoneExt":26,"email":56},"Carlos Galán Arriola, PhD","914 53 12 00","carlos.galan@cnic.es",{"facility":58,"status":26,"city":43,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":59,"geoPoint":61,"contacts":62},"Hospital La Princesa",{"type":47,"coordinates":60},[49,50],{"lat":50,"lon":49},[63],{"name":64,"role":34,"phone":65,"phoneExt":26,"email":66},"Beatriz López Melgar, MD","915 20 22 00","blopezm@salud.madrid.org",{"facility":68,"status":26,"city":43,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":69,"geoPoint":71,"contacts":72},"Hospital Ramón y Cajal",{"type":47,"coordinates":70},[49,50],{"lat":50,"lon":49},[73],{"name":74,"role":34,"phone":75,"phoneExt":26,"email":76},"Juan Manuel Monteagudo Ruiz, MD in Cardiology","913 36 80 00","j5469m@gmail.com",{"facility":78,"status":26,"city":79,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Complejo Asistencial Universitario de Salamanca","Salamanca",{"type":47,"coordinates":81},[82,83],-3.67975,40.42972,{"lat":83,"lon":82},[86,88],{"name":87,"role":34,"phone":35,"phoneExt":26,"email":36},"Candelas Perez del Villar, MD in Cardiology",{"name":38,"role":34,"phone":26,"phoneExt":26,"email":39},{"facility":90,"status":26,"city":91,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Hospital Clínico Universitario de Valencia","Valencia",{"type":47,"coordinates":93},[94,95],-0.37966,39.47391,{"lat":95,"lon":94},[98],{"name":99,"role":34,"phone":26,"phoneExt":100,"email":101},"Víctor Marcos Garcés","961 97 35 00","vic_mg_cs@hotmail.com",{"type":103,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100613576","using-advanced-ct-scans-and-blood-markers-to-better-understand-heart-damage-and-recovery-after-a-heart-attack-100613576",false,"NCT07268391","Using Advanced CT Scans and Blood Markers to Better Understand Heart Damage and Recovery After a Heart Attack","SPEctral CT and miRna In Acute Myocardial Infarction for Comprehensive Adverse Remodeling Evaluation","Inclusion Criteria:\n\n* Adults ≥18 years.\n* First STEMI treated with primary PCI.\n* Left ventricular ejection fraction (LVEF) ≤45% during index hospitalization.\n* Ability to provide informed consent.\n\nExclusion Criteria:\n\n* Contraindication to iodinated contrast media.\n* Chronic kidney disease with eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m².\n* Prior myocardial infarction or known cardiomyopathy.\n* Contraindication to CT or MRI imaging.\n* Life expectancy \\\u003C1 year due to non-cardiac conditions.","ALL","18 Years",{"count":114,"type":115},95,"ESTIMATED","INTERVENTIONAL",[118],"NA","Acute myocardial infarction with ST-segment elevation (STEMI) remains a leading cause of morbidity and mortality worldwide. Although advances in reperfusion therapy have reduced early mortality, many patients later develop adverse ventricular remodeling (AVR), which increases the risk of heart failure and cardiovascular death. Current imaging methods, such as echocardiography and cardiac magnetic resonance (CMR), provide valuable prognostic information but have limitations in availability, cost, and their ability to predict AVR early and individually.\n\nSpectral computed tomography (CT) is an emerging imaging technique that can characterize myocardial tissue, quantify infarct size, assess microvascular obstruction, and detect complications, with lower contrast and radiation requirements compared to conventional CT. In parallel, circulating microRNAs (miRNAs) have been identified as stable and non-invasive biomarkers that reflect key biological processes in post-infarction remodeling. Several miRNAs are linked to fibrosis, apoptosis, and ventricular remodeling, suggesting their potential to complement imaging findings in risk prediction.\n\nThis study proposes a multicenter, prospective cohort of patients with STEMI and reduced left ventricular function to evaluate whether combining spectral CT tissue characterization with serum miRNA profiling can improve early prediction of AVR. The main objective is to generate and validate a multiparametric prognostic model integrating imaging and molecular biomarkers to identify high-risk patients who may benefit from closer monitoring and tailored therapeutic strategies.",[121],"Acute Myocardial Infarction (AMI)",[123,124,125,126,127],"magnetic resonance","miRNA","myocardial infarction","adverse ventricular remodeling","spectral computed tomography","NOT_YET_RECRUITING","2025-12-09",{"date":131,"type":132},"2025-12-10","ACTUAL",{"date":134,"type":115},"2026-01",{"date":136,"type":115},"2028-12",{"name":5,"class":6},5]