[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617148":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":58,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":25,"enrollmentInfo":70,"targetDuration":25,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":84,"overallStatus":90,"whyStopped":25,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"National Cancer Institute, Naples","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard Fluid Management","ACTIVE_COMPARATOR","Participants receive intraoperative intravenous fluid therapy managed according to usual clinical practice, without artificial intelligence guidance. Fluid administration is determined by the attending clinician based on standard monitoring and clinical judgment.",[13],"Other: Standard fluid management",{"label":15,"type":16,"description":17,"interventionNames":18},"AI-Assisted Fluid Management","EXPERIMENTAL","Participants assigned to this arm receive intraoperative intravenous fluid therapy supported by an artificial intelligence-based clinical decision support system. The system analyzes real-time hemodynamic data and provides recommendations for fluid administration. Clinicians are strongly encouraged to follow these recommendations but may accept or override them based on clinical judgment.",[19],"Other: Artificial Intelligence-Assisted Fluid Management",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Artificial Intelligence-Assisted Fluid Management","In this intervention, intraoperative intravenous fluid management is supported by an artificial intelligence-based clinical decision support system. The system continuously analyzes real-time hemodynamic data derived from standard intraoperative monitoring and provides recommendations for intravenous fluid administration. Clinicians are strongly encouraged to follow these recommendations but retain full responsibility and may accept or override them based on clinical judgment. The intervention is applied during the intraoperative period only and does not replace standard anesthetic care.",[15],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Standard fluid management","In this intervention participants receive intraoperative intravenous fluid therapy managed according to usual clinical practice, without artificial intelligence guidance. Fluid administration is determined by the attending clinician based on standard monitoring and clinical judgment.",[9],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"gilda pasta, MD","CONTACT","+393498369411","g.pasta@istitutotumori.na.it",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":39},"Francesca Bifulco, MD","+393471752075","f.bifulco@istituotumori.na.it",[41],{"facility":42,"status":25,"city":43,"state":25,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"IRCCS Istituto Nazionale Tumori \"Fondazione G. Pascale\"","Naples","80100","Italy","IT",{"type":48,"coordinates":49},"Point",[50,51],14.26811,40.85216,{"lat":51,"lon":50},[54],{"name":55,"role":33,"phone":56,"phoneExt":25,"email":57},"IRCCS Istituto Nazionale Tumori \"Fondazione G. Pascale\" Cristina Romano, Data Manager","+3909117770626","mc.romano@istitutotumori.na.it",{"type":59,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100617148","using-artificial-intelligence-to-guide-fluid-therapy-during-major-cancer-surgery-a-randomized-controlled-trial-100617148",false,"NCT07314853","Using Artificial Intelligence to Guide Fluid Therapy During Major Cancer Surgery: A Randomized Controlled Trial","Fluid Optimization in Cancer Surgery With AI-Assisted Management - FOCUS-AFM Trial","FOCUS-AFM","Inclusion Criteria:\n\n* Age ≥ 18 years\n* American Society of Anesthesiologists (ASA) Physical Status II-IV\n* Undergoing major abdominal oncologic surgery (open or laparoscopic) with an expected duration \\>2 hours\n* Planned invasive arterial pressure monitoring\n* Ability to understand and sign informed consent\n\nExclusion Criteria:\n\n* Significant arrhythmias (e.g., persistent atrial fibrillation)\n* Severe aortic stenosis\n* Emergency surgery\n* Sepsis\n* End-stage renal disease on dialysis\n* Pregnancy\n* Impossibility to cannulate the radial artery\n* Refusal to participate or refusal of data processing consent","ALL","18 Years",{"count":71,"type":72},176,"ESTIMATED","INTERVENTIONAL",[75],"NA","The goal of this clinical trial is to learn if using artificial intelligence to guide intravenous fluid therapy during major cancer surgery can help keep blood pressure more stable compared with usual care in adult patients undergoing major cancer surgery. The main questions it aims to answer are:\n\n* Does artificial intelligence-guided fluid therapy reduce hypotensive events during surgery?\n* Does this approach improve recovery and reduce complications after major cancer surgery?\n\nResearchers will compare artificial intelligence-guided fluid therapy with standard fluid management to see if the artificial intelligence-guided approach provides better support during surgery.\n\nParticipants will:\n\n* Undergo major cancer surgery under general anesthesia\n* Receive either artificial intelligence-guided fluid management or standard fluid management during surgery\n* Be monitored during and after surgery as part of routine clinical care\n* Be followed after surgery to assess recovery and possible complications",[78,79,80,81,82,83],"Neoplasm","Cancer","Hemodynamic (MAP) Stability","Cancer Surgery","Artificial Intelligence (AI)","Fluid Therapy DURING SURGERY",[85,86,87,88,89],"randomized controlled trial","cancer","fluid balance","fluid therapy","artificial intelligence","NOT_YET_RECRUITING","2026-01-07",{"date":93,"type":94},"2026-01-09","ACTUAL",{"date":96,"type":72},"2026-02",{"date":98,"type":72},"2029-02",{"name":5,"class":6},1]