[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642951":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":40,"locations":46,"responsibleParty":63,"collaborators":66,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":27,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":91,"whyStopped":27,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University of British Columbia","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Reduced Sulfur Diet","EXPERIMENTAL","Participants will consume a novel elemental formula (mBiota Elemental, Good LFE, Santa Monica, CA) as their sole source of nutrition for two weeks. followed by a 10-week reduced sulfur diet. The reduced sulfur diet is designed to limit dietary sources of sulfur-containing compounds that may contribute to hydrogen sulfide production by the gut microbiota.",[13,14],"Dietary Supplement: Elemental formula (mBiota Elemental, Good LFE, Santa Monica, CA)","Behavioral: Reduced Sulfur diet",{"label":16,"type":17,"description":18,"interventionNames":19},"Habitual Diet","ACTIVE_COMPARATOR","Participants will complete a 2-week elemental diet intervention followed by a 10-week habitual diet. Participants will be instructed to resume and maintain their usual dietary intake without specific sulfur-restriction recommendations.",[13,20],"Behavioral: Habitual Diet",[22,28,33],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DIETARY_SUPPLEMENT","Elemental formula (mBiota Elemental, Good LFE, Santa Monica, CA)","Elemental liquid diets (EDs) are a subset of Exclusive Enteral Nutrition (EEN). Similar to EEN, they are nutritionally complete formulas, but differ in that they consist of free amino acids, monosaccharides, and fatty acids instead of whole, intact macronutrients, which are designed for optimal digestibility and to minimize antigenicity. EDs have been shown to reduce immune activation, favourably modulate the microbiota, suppress proinflammatory cytokines, support epithelial repair, and exclude common dietary additives that may provoke inflammation.",[16,9],null,{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":27},"BEHAVIORAL","Reduced Sulfur diet","This diet excludes high sulfur foods (e.g., red meat, seafood, eggs), cruciferous vegetables, dried fruits, and fermented beverages. It also accounts for sulfate intake from drinking water and processed food additives.",[9],{"type":29,"name":16,"description":34,"armGroupLabels":35,"otherNames":27},"Participants randomized to the comparator group will continue their usual dietary intake for 10 weeks without specific dietary restrictions.",[16],[37],{"name":38,"affiliation":5,"role":39},"Natasha Haskey, RD, PhD","PRINCIPAL_INVESTIGATOR",[41],{"name":42,"role":43,"phone":44,"phoneExt":27,"email":45},"Natasha Haskey, PhD","CONTACT","250-807-9597","natasha.haskey@ubc.ca",[47],{"facility":48,"status":27,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"University of British Columbia-Okanagan","Kelowna","British Columbia","V1V 1V7","Canada","CA",{"type":55,"coordinates":56},"Point",[57,58],-119.48568,49.88307,{"lat":58,"lon":57},[61,62],{"name":38,"role":43,"phone":44,"phoneExt":27,"email":45},{"name":38,"role":39,"phone":27,"phoneExt":27,"email":27},{"type":39,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Natasha Haskey","Principle Investigator, Research Associate, Department of Biology",[67],{"name":68,"class":6},"University of Calgary","100642951","using-breath-tests-to-study-gut-sulfur-changes-during-dietary-therapy-100642951",false,"NCT07640659","Using Breath Tests to Study Gut Sulfur Changes During Dietary Therapy","Sulfur on the Breath: Using Breath Biomarkers to Monitor Gut Microbial Sulfur Metabolism During Elemental and Reduced Sulfur Dietary Therapy","Sulfur-UC","Inclusion Criteria:\n\n* Age 19-70 years.\n\n  =Diagnosis of mild-to-moderate ulcerative colitis, defined by a partial Mayo score (pMayo) of 2-7.\n* Evidence of active inflammation at enrollment, defined as:\n* C-reactive protein (CRP) \\> 5 mg\u002FL; or\n* Fecal calprotectin (FCP) \\> 200 µg\u002Fg.\n* Receiving stable medical therapy for ulcerative colitis for at least 8 weeks prior to enrollment.\n* No corticosteroid use at the time of recruitment.\n* Under consideration by the treating physician for treatment escalation or biologic switch due to inadequate response to current therapy.\n\nExclusion Criteria:\n\n* Partial Mayo score (pMayo) \\> 7.\n* Pregnant or breastfeeding.\n* Body mass index (BMI) \\\u003C 18 kg\u002Fm².\n* History of an eating disorder.\n* Severe psychiatric disorder.\n* Severe medical conditions, including:\n* Active cancer;\n* Significant cardiovascular disease;\n* Diabetes mellitus; or\n* Severe food allergies.\n* Known allergy or intolerance to corn, dextrose, or maltodextrin.\n* Antibiotic use within 3 months prior to enrollment.\n* Probiotic use within 3 months prior to enrollment.\n* Use of herbal anti-inflammatory supplements during the study period, including but not limited to:\n* Serrapeptidase;\n* Curcumin;\n* Boswellia; or\n* Bromelain.\n* History of major gastrointestinal surgery, including:\n* Ostomy;\n* Total colectomy; or\n* Short bowel syndrome.\n* Inability or unwillingness to comply with study procedures, including anticipated travel or other commitments that may interfere with participation.","ALL","19 Years","70 Years",{"count":81,"type":82},45,"ESTIMATED","INTERVENTIONAL",[85],"NA","This study aims to test whether a short liquid-based diet, followed by a low-sulfur eating plan, is safe, manageable, and helpful for people with mild to moderate ulcerative colitis. Investigators want to see if this approach can improve gut health, lower inflammation, and reduce symptoms. Investigators will also test breath samples as an easy, non-invasive way to track gut bacteria activity and disease changes. Investigators believe this diet plan can reduce harmful gut bacteria that produce irritating sulfur compounds, leading to better gut health and measurable improvements that can be detected through breath testing.",[88],"Ulcerative Colitis (UC)",[90],"Ulcerative colitis","NOT_YET_RECRUITING","2026-06-05",{"date":94,"type":95},"2026-06-11","ACTUAL",{"date":97,"type":82},"2026-06-01",{"date":99,"type":82},"2029-12-31",{"name":5,"class":6},1]