[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100454173":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":35,"centralContacts":40,"locations":46,"responsibleParty":67,"collaborators":24,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":24,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":24,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":49,"whyStopped":24,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"San Francisco Veterans Affairs Medical Center","FED",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Major Depression Disorder Group: iTBS-EEG","EXPERIMENTAL","Device: MagVenture MagPro R30 device with a Cool-DB80 A\u002FP coil (Farum, Denmark) Stimulation: intermittent theta stimulation (iTBS): the investigators will stimulate a dorsomedial prefrontal cortex target at the scalp location (0x 60y 60z). Standard iTBS of 50Hz triplet bursts, 5 times each second with a 2 s on \u002F 8 s off duty cycle for 600 pulses per hemisphere (1200 pulses total) will be applied for a total stimulation time of 6:40 minutes, per session; total session length, including setup is 10-15 min.",[13],"Device: TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device \u002F Cool-DB80 A\u002FP coil",{"label":15,"type":16,"description":17,"interventionNames":18},"Major Depression Disorder Group: SHAM-EEG","SHAM_COMPARATOR","Device: MagVenture MagPro R30 device with a Cool-DB80 A\u002FP coil (Farum, Denmark) Stimulation: sham stimulation (SHAM): Sham stimulation will entail the same procedures for the active stimulation day, but with the sham side of the DB-80 A\u002FP placed exactly on the same anatomical target in the same position and duration, but without any active stimulation.\n\n\\*Note, iTBS and SHAM stimulation sessions will occur on separate days scheduled one week apart (counterbalanced, across subjects). The two stimulation visits follow identical procedures (with the sole difference being active vs. sham rTMS stimulation), with each followed directly by post-stimulation EEG assessment with SLOT and MID tasks.",[19],"Device: SHAM (inactive) TMS stimulation",{"label":21,"type":22,"description":23,"interventionNames":24},"Baseline Evaluation (Major Depressive Disorder and Healthy Control Groups)","NO_INTERVENTION","HC and MDD participants will have visits for clinical assessment and a baseline EEG session to complete reward processing tasks (SLOT AND MID). The SLOT task is a 288-trial EEG task developed in our laboratory. Design features mimic structural characteristics common to real-word slot machines, including sound effects and visualizations, and the display consists of 3 sequentially populated slot reels. Participants initiate each trial via button press, after which timing of the slot reels is automated, such that reward outcome is independent of task performance.\n\nThe MID task is a 130-trial EEG task designed to model anticipatory and consummatory sub-stages of reward processing in the context of participants being rewarded based on their response times to a cued target detection task.",null,[26,31],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":24},"DEVICE","TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device \u002F Cool-DB80 A\u002FP coil","Active Session: Single session of standard iTBS of 50Hz triplet bursts, 5 times each second with a 2 s on \u002F 8 s off duty cycle for 600 pulses per hemisphere (1200 pulses total) will be applied for a total stimulation time of 6:40 minutes",[9],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":24},"SHAM (inactive) TMS stimulation","Sham neurostimulation (SHAM) entails use of the sham side of the D-B80 A\u002FP placed over the same anatomical target, without any active stimulation.",[15],[36],{"name":37,"affiliation":38,"role":39},"Susanna L Fryer, PhD","University of California, San Francisco","PRINCIPAL_INVESTIGATOR",[41],{"name":42,"role":43,"phone":44,"phoneExt":24,"email":45},"Jason B Hemmerle, MBA","CONTACT","4152214810","jason.hemmerle@ucsf.edu",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"San Francisco VA Medical Center","RECRUITING","San Francisco","California","94121","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-122.41942,37.77493,{"lat":59,"lon":58},[62,65],{"name":37,"role":43,"phone":63,"phoneExt":64,"email":45},"415-221-4810","23789",{"name":66,"role":39,"phone":24,"phoneExt":24,"email":24},"Susanna Fryer, PhD",{"type":39,"investigatorFullName":66,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Staff Clinical Psychologist (VA) and Assistant Professor (UCSF)","100454173","using-electrophysiology-to-index-non-invasive-brain-stimulation-effects-on-reward-system-functioning-in-depression-100454173",false,"NCT05194098","Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression","• Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco.\n\nInclusion Criteria:\n\n* All participants\n\n  * 18-65 years old\n  * Normal (or corrected to normal) vision\n* Participants with MDD\n\n  * Meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for MDD\n  * Screened for TMS and MRI safety\n  * On a stable psychiatric medication regime for \\> 1 month\n\nExclusion Criteria (all participants):\n\n* Premorbid IQ estimate \\\u003C 70\n* Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)\n* Loss of consciousness \\> 30 minutes or any loss of consciousness with neurological sequelae\n* Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology), or other physical conditions if they preclude participation in EEG, TMS, or MRI protocols (e.g. peripheral nerve damage, limb paralysis etc.)\n* Substance dependence, within the past year, current (past 3 months) substance misuse, or failed urine toxicology on the day of neuroimaging sessions\n* Known claustrophobia\n* Pregnancy (a pregnancy urine test will be conducted to rule-out pregnancy)\n\nExclusion criteria (Participants with MDD only)\n\n* Past or present DSM-5 (SCID-5) 'Schizophrenia Spectrum or Other Psychotic Disorder' diagnosis\n* Past or present DSM-5 (SCID-5) Bipolar and Related Disorders Diagnosis\n* Past or present DSM-5 (SCID-5) MDD with psychotic features (mood congruent or mood incongruent)\n* Past or present DSM-5 (SCID-5) Gambling Disorder\n\nExclusion Criteria (HCs only)\n\n• DSM-5 (SCID-5) criteria for any psychiatric disorder",true,"ALL","18 Years","65 Years",{"count":80,"type":81},45,"ESTIMATED","INTERVENTIONAL",[84],"NA","Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will improve understanding of the circuit alterations that underlie motivation and pleasure deficits in depression, and could also lead to the development of biologically-based markers of neurostimulation-based treatment response.",[87],"Major Depressive Disorder",[87,89,90,91,92],"Reward Processing","EEG","rTMS Neurostimulation","dorsal medial prefrontal cortex","2024-07-31",{"date":95,"type":96},"2024-08-02","ACTUAL",{"date":98,"type":96},"2021-10-01",{"date":100,"type":81},"2024-09-30",{"name":5,"class":6},1]