[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617037":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":25,"responsibleParty":55,"collaborators":10,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":10,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":10,"enrollmentInfo":68,"targetDuration":71,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"The University of Texas at Arlington","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy Controls",null,"Individuals without PAD",{"label":13,"type":10,"description":14,"interventionNames":10},"Cases with PAD","Individuals with PAD",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Michael Nelson, PhD","CONTACT","8175130383","michael.nelson3@uta.edu",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"Rajvi Shah, MPH","2147557343","rajvi.shah@uta.edu",[26,44],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"University of Texas at Arlington","RECRUITING","Arlington","Texas","76010","United States","US",{"type":35,"coordinates":36},"Point",[37,38],-97.10807,32.73569,{"lat":38,"lon":37},[41],{"name":42,"role":18,"phone":43,"phoneExt":10,"email":10},"Rajvi Shah","2147557",{"facility":45,"status":46,"city":29,"state":30,"zip":47,"country":32,"countryCode":33,"cosmosGeoPoint":48,"geoPoint":50,"contacts":51},"University of Texas Arlington","NOT_YET_RECRUITING","76019",{"type":35,"coordinates":49},[37,38],{"lat":38,"lon":37},[52,53],{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},{"name":17,"role":54,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":54,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Michael Nelson","Professor","100617037","using-near-infrared-light-to-better-understand-peripheral-artery-disease-100617037",false,"NCT07313410","Using Near-Infrared Light to Better Understand Peripheral Artery Disease","Near-Infrared Diffuse Correlation Spectroscopy to Better Define the Pathophysiology of Peripheral Artery Disease","Inclusion Criteria:\n\n* Cases, Aim 1\n\n  1. 18 or older\n  2. willing to participate under the conditions described in the informed consent form (ICF)\n  3. eligible to sign the ICF\n  4. established diagnosis of PAD confirmed by a physician\n  5. able to comply with the study requirements\n* Cases, Aim 2\n\n  1\\) completed Aim 1\n* Controls 1) asymptomatic, with no history or diagnosis of peripheral artery disease\n\nExclusion Criteria:\n\n* Cases, Aim 1\n\n  1. Ankle-Brachial Index \\>0.9 or \\\u003C0.4\n  2. isolated disease in aorta\u002Filiac vessels\n  3. unstable angina or myocardial infarction in past 12 months\n  4. orthopedic or other physical limitations which would prevent data collection\n  5. contraindications to MRI, including presence of a Pacemaker, presence of bone growth\u002F bone fusion stimulators, presence of tissue expander, presence of cochlear implants, unable to ambulate for 10 feet, receiving continuous Oxygen therapy, pregnancy, permanent Jewelry (screened using MRI safety screening form and verbal screening by MRI operator\n* Cases, Aim 2\n\n  1. unstable angina or myocardial infarction in past 12 months\n  2. orthopedic or other physical limitations which would prevent data collection\n  3. contraindications to MRI, including presence of a pacemaker, presence of bone growth\u002F bone fusion stimulators, presence of tissue expander, presence of cochlear implants, unable to ambulate for 10 feet, receiving continuous Oxygen therapy, pregnancy, permanent Jewelry (screened using MRI safety screening form and verbal screening by MRI operator).\n* Controls 1) history of peripheral artery disease 2) overt cardiovascular disease (e.g. heart failure) 3) known pulmonary disease (excluding mild asthma) 4) current tobacco use 5) orthopedic or other physical limitations which would prevent data collection, 6) BP \\>150\u002F90 mmHg at screening 7) contraindications to MRI, including presence of a pacemaker, presence of bone growth\u002F bone fusion stimulators, presence of tissue expander, presence of cochlear implants, unable to ambulate for 10 feet, receiving continuous Oxygen therapy, pregnancy, permanent Jewelry (screened using MRI safety screening form and verbal screening by MRI operator).",true,"ALL","18 Years",{"count":69,"type":70},120,"ESTIMATED","6 Months","OBSERVATIONAL","The goal of this study is to better understand how blood flows and how oxygen is utilized in the lower limbs of people who suffer from peripheral artery disease. This study will also assess how these factors affect treatment outcomes.\n\nSpecific aims include:\n\nAim 1: Utilize BB-NIR-DCS to differentiate PAD patients experiencing primary oxygen delivery limitations from those suffering from mitochondrial dysfunction.\n\nAim 2: Test the efficacy of BB-NIR-DCS at predicting individual responses to vascular intervention.",[75],"Peripheral Artery Disease (PAD)",[77,78,79,80,81,82],"Exercise MRI","Functional Performance","Ankle-Brachial Index","Questionnaires","MRI","Peripheral Artery Disease","2025-12-16",{"date":85,"type":86},"2026-01-02","ACTUAL",{"date":88,"type":86},"2025-11-01",{"date":90,"type":70},"2028-12-31",{"name":5,"class":6},2]