[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607725":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":15,"locations":21,"responsibleParty":39,"collaborators":42,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":7,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":7,"enrollmentInfo":55,"targetDuration":7,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":71,"whyStopped":7,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"University of Medicine and Pharmacy at Ho Chi Minh City","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"PROCEDURE","Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth.","After obtaining informed consent, the study will be conducted over 2 appointments, 2-4 weeks apart.\n\nThe first appointment will focus on infection control and inflammation reduction. The canal will be instrumented with a single-file system. The canal will be then irrigated sequentially with 3% sodium hypochlorite (NaOCl), saline, and 17% ethylenediaminetetraacetic Acid (EDTA) to ensure thorough disinfection. Finally, a temporary filling of Glass Ionomer Cement will be placed over an intracanal dressing of calcium hydroxide.\n\nAt the second appointment, the final treatment will be performed based on the patient's group:\n\nControl Group - Blood clot method for regenerative endodontics. Experimental Group 1 - Regenerative endodontics using advanced platelet-rich fibrin (A-PRF+).\n\nExperimental Group 2 - Regenerative endodontics using injectable platelet-rich fibrin (i-PRF).\n\nAll three groups will be then sealed with mineral trioxide aggregate (MTA) and a final composite resin filling.",[14],"PRF in regenerative endodontic treatment",[16],{"name":17,"role":18,"phone":19,"phoneExt":7,"email":20},"VI THI TUONG TRAN, Master of Science","CONTACT","84 + 357199931","tuongvitranthi94@gmail.com",[22],{"facility":23,"status":7,"city":24,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Odonto-Maxillo-Facial Hospital and University of Medicine and Pharmacy at Ho Chi Minh City","Ho Chi Minh City","70000","Vietnam","VN",{"type":29,"coordinates":30},"Point",[31,32],106.62965,10.82302,{"lat":32,"lon":31},[35,37],{"name":17,"role":18,"phone":36,"phoneExt":7,"email":20},"84+ 357199931",{"name":17,"role":38,"phone":7,"phoneExt":7,"email":7},"PRINCIPAL_INVESTIGATOR",{"type":38,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Tran Thi Tuong Vi","Principal Investigator",[43],{"name":44,"class":45},"Odonto-Maxillo Facial Hospital in Ho Chi Minh City","UNKNOWN","100607725","using-platelet-rich-fibrin-in-regenerative-endodontic-treatment-in-mature-permanent-teeth-100607725",false,"NCT07192289","Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth","Inclusion Criteria:\n\nParticipants had a single-rooted tooth with necrotic pulp (negative response to electric pulp testing), with or without periapical pathology (acute apical periodontitis of pulpal origin, chronic periapical periodontitis, periapical abscess with sinus, periapical abscess without sinus), and gave their consent to participate in the study.\n\nExclusion Criteria: Study samples will be excluded if any of the following criteria are met:\n\n* The tooth has had previous endodontic treatment.\n* The root apex is not fully developed, or there is root resorption\u002Fcracking\u002Ffracture.\n* The tooth has severe tooth loss and is indicated for extraction, or is indicated for restoration with a post or cast core after endodontic treatment.\n* The root canal is calcified.\n* The root canal curvature is greater than 25º.\n* The tooth has a periapical cyst or is associated with a jawbone cyst.\n* The tooth has a periodontal pocket deeper than 4 mm.\n* The tooth has no occlusal contact.\n* The patient is pregnant.\n* The patient has diabetes or HIV or other immunocompromised conditions.",true,"ALL","18 Years",{"count":56,"type":57},57,"ESTIMATED","INTERVENTIONAL",[60],"NA","This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in regenerative endodontic treatment of mature permanent teeth with necrotic pulp. The study will compare the effectiveness of PRF-based treatment with conventional blood clot-based regenerative endodontics.",[63,64,65,66],"Chronic Apical Periodontitis","Necrosis of Pulp","Acute Apical Periodontitis of Pulpal Origin","Periapical Abscess",[68,69,70],"PRF","regenerative endodontic treatment","mature permanent treatment","NOT_YET_RECRUITING","2025-09-21",{"date":74,"type":75},"2025-09-25","ACTUAL",{"date":77,"type":57},"2025-09-15",{"date":79,"type":57},"2027-08-31",{"name":5,"class":6},1]