[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538596":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":41,"collaborators":45,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":10,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"obese individuals [Body Mass Index (BMI) > 30 affected by prostate cancer",null,[12],"Other: observational study",{"label":14,"type":10,"description":10,"interventionNames":10},"normal-weight individuals [18 \u003C BMI \u003C 25] affected by prostate cancer",[16],{"type":6,"name":17,"description":17,"armGroupLabels":18,"otherNames":10},"observational study",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Giancarlo Albo, MD,","CONTACT","00390255034501","giancarlo.albo@policlinico.mi.it",[26],{"facility":27,"status":28,"city":29,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"IRCCS Cà Granda Ospedale Maggiore Policlinico Milano","RECRUITING","Milan","Italy","IT",{"type":33,"coordinates":34},"Point",[35,36],9.18951,45.46427,{"lat":36,"lon":35},[39],{"name":40,"role":22,"phone":10,"phoneExt":10,"email":10},"giancarlo albo, MD",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Giancarlo Albo","associate professor",[46],{"name":47,"class":48},"National Research Council","AMBIG","100538596","using-tissue-based-spatial-data-to-understand-how-obesity-related-tumor-metabolites-fuel-prostate-cancer-progression-100538596",false,"NCT06292897","Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression","Integrating Tissue-based Spatial Information to Elucidate How Obesity-induced Tumour Metabolites Drive Prostate Cancer Progression","OBESITA'&PCa","Inclusion Criteria:\n\n* affected by prostate cancer\n\nExclusion Criteria:\n\n\\-","MALE","18 Years",{"count":60,"type":61},25,"ESTIMATED","OBSERVATIONAL","Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1\u002F-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight\u002Fobese (BMI \\> 27.5) and non-severely overweight\u002Fnormoweight (BMI \\\u003C 27.5) patients affected by prostate carcinoma.\n\nii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients.\n\niii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and\u002For deregulation of relevant oncogenic pathways.",[65,66,67,68,69],"Prostate Cancer","Prostate Adenocarcinoma","Prostate Neoplasm","Prostatic Neoplasm","Obesity","2024-02-27",{"date":72,"type":73},"2024-03-05","ACTUAL",{"date":75,"type":73},"2023-03-20",{"date":77,"type":61},"2027-01-15",{"name":5,"class":6},1]