[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100537152":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":25,"locations":26,"responsibleParty":46,"collaborators":25,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":25,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":25,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":25,"overallStatus":28,"whyStopped":25,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Auburn University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TMS A","EXPERIMENTAL","Active continuous thetaburst stimulation administered over right dorsolateral prefrontal cortex for 40 seconds (600 pulses total)",[13],"Device: TMS",{"label":15,"type":16,"description":17,"interventionNames":18},"TMS B","SHAM_COMPARATOR","Sham continuous thetaburst stimulation administered over right dorsolateral prefrontal cortex for 40 seconds (600 pulses total)",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","TMS","TMS will be administered using a Cool B-65 coil to a personalized right dlPFC region.",[9,15],null,[27],{"facility":5,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Auburn","Alabama","36849","United States","US",{"type":35,"coordinates":36},"Point",[37,38],-85.48078,32.60986,{"lat":38,"lon":37},[41],{"name":42,"role":43,"phone":44,"phoneExt":25,"email":45},"Travis Evans, PhD","CONTACT","3348444550","tce0018@auburn.edu",{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Travis Evans","Assistant Professor","100537152","using-tms-to-understand-neural-processes-of-social-motivation-100537152",false,"NCT06274112","Using TMS to Understand Neural Processes of Social Motivation","Personalized Neuromodulation Targeting Dysregulated Motivational Responses Underlying Social Avoidance Behavior","Inclusion Criteria:\n\n* A diagnosis of Major Depressive Disorder OR a diagnosis of Social Anxiety Disorder (assessed\u002Fconfirmed at screening visit).\n* Scoring above clinical threshold on a measure of social avoidant behavior (assessed\u002Fconfirmed at phone screen).\n\nExclusion Criteria:\n\n* Unstable psychotropic medication regimen (i.e., changes in psychotropic medication or dosage in past 3 months).\n* Current or lifetime diagnosis of Bipolar Disorder.\n* A diagnosis of substance use disorder within past 12 months.\n* A diagnosis of psychotic-spectrum disorder such as Schizophrenia.\n* Pregnancy or probable pregnancy.\n* Medical illness or medical treatment that would preclude or inhibit study participation.\n* Neurological disorder associated with brain damage.\n* History of seizures or head trauma with loss of consciousness \\> 5 minutes.\n* Family history of epilepsy or personal epilepsy\u002Fseizures\n* Ferromagnetic implants or ferrmagnetic objects within body (e.g., pacemaker).","ALL","25 Years","50 Years",{"count":61,"type":62},40,"ESTIMATED","INTERVENTIONAL",[65],"NA","The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation.\n\nParticipant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period. The first study visit involves answering survey questions, a clinical interview, and computer tasks. The second study visit involves a magnetic resonance imaging (MRI) scan, computer tasks, and a brief TMS protocol. The second and third study visits involve a full session of TMS followed by an MRI scan and computer tasks.\n\nAdults in the Auburn\u002FOpelika area and surrounding areas who avoid social situations, experience symptoms of depression or social anxiety, and are between 25 years old and 50 years old are eligible to participate.",[68,69,70],"Social Avoidant Behavior","Major Depressive Disorder","Social Anxiety Disorder","2026-03-01",{"date":73,"type":74},"2026-03-03","ACTUAL",{"date":76,"type":74},"2025-09-30",{"date":78,"type":62},"2029-07-31",{"name":5,"class":6},1]