[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100465659":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":42,"responsibleParty":57,"collaborators":60,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":40,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":40,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":40,"overallStatus":45,"whyStopped":40,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Mclean Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active cerebellum rTMS","ACTIVE_COMPARATOR","Cerebellar targeted iTBS, twice daily, one week.",[13],"Device: Repetitive Transcranial Magnetic Stimulation (rTMS)",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham cerebellum rTMS","SHAM_COMPARATOR","Cerebellar targeted sham iTBS, twice daily, one week.",[19],"Device: Sham Repetitive Transcranial Magnetic Stimulation (rTMS)",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Repetitive Transcranial Magnetic Stimulation (rTMS)","rTMS is a technique of TMS that allows for selective external manipulation of neural activity in a non-invasive manner. During rTMS a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field, which in turn induces electrical current in neurons and allows for modulation of neural circuitry.\n\nThe rTMS pulses will be delivered in a pattern consisting of 2 s trains of 3 pulses at 50 Hz, repeated at 5 Hz every 10s for 600 total pulses.",[9],[27],"iTBS",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Sham Repetitive Transcranial Magnetic Stimulation (rTMS)","rTMS is a technique of TMS that allows for selective external manipulation of neural activity in a non-invasive manner. During rTMS a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field, which in turn induces electrical current in neurons and allows for modulation of neural circuitry.\n\nThe rTMS pulses will be delivered in a pattern consisting of 2 s trains of 3 pulses at 50 Hz, repeated at 5 Hz every 10s for 600 total pulses.\n\nSham is achieved by using a coil with a magnetic shield preventing magnetic field from reaching the head.",[15],[27],[34],{"name":35,"affiliation":5,"role":36},"Mark Halko, PhD","PRINCIPAL_INVESTIGATOR",[38],{"name":35,"role":39,"phone":40,"phoneExt":40,"email":41},"CONTACT",null,"mhalko@mclean.harvard.edu",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":40},"McLean Hospital","RECRUITING","Belmont","Massachusetts","02478","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-71.17867,42.39593,{"lat":55,"lon":54},{"type":36,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":40,"oldOrganization":40},"Mark A. Halko, PhD","Assistant Professor of Psychiatry",[61,63],{"name":62,"class":6},"Beth Israel Deaconess Medical Center",{"name":64,"class":65},"National Institute of Mental Health (NIMH)","NIH","100465659","using-transcranial-magnetic-stimulation-tms-to-understand-hallucinations-in-schizophrenia-100465659",false,"NCT05343598","Using Transcranial Magnetic Stimulation (TMS) to Understand Hallucinations in Schizophrenia","Empirical Validation of a Cerebellar-cortical Hallucination Circuit","Inclusion Criteria:\n\n* Diagnosis of schizophrenia or schizoaffective disorder\n\nExclusion Criteria:\n\n* substance use disorder in past 3 months\n* ambidexterity\n* contraindications for TMS or MRI including :\n* history of neurological disorder\n* history of head trauma resulting in loss of consciousness\n* history of seizures or diagnosis of epilepsy or first degree relative family history of epilepsy\n* metal in brain or skull\n* implanted devices such as a pacemaker, medication pump, nerve stimulator or ventriculoperitoneal shunt\n* claustrophobic in MRI","ALL","18 Years","55 Years",{"count":77,"type":78},68,"ESTIMATED","INTERVENTIONAL",[81],"NA","This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study how hallucinations work in schizophrenia.\n\nTMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study the investigators will be stimulating the brain to learn more about how TMS might improve these symptoms of schizophrenia.",[84,85],"Schizophrenia","Schizo Affective Disorder","2026-01-21",{"date":88,"type":89},"2026-01-22","ACTUAL",{"date":91,"type":89},"2021-10-13",{"date":93,"type":78},"2026-10-31",{"name":5,"class":6},1]