[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638204":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":38,"responsibleParty":65,"collaborators":12,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":12,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":91,"overallStatus":97,"whyStopped":12,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Brigham and Women's Hospital","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment as usual","NO_INTERVENTION","This group will remain on their CGRP injectable monoclonal antibody migraine preventive medication",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Active Treatment","ACTIVE_COMPARATOR","This group will participate in the four week active virtual reality treatment and will also remain on their CGRP mAb medication.",[18],"Behavioral: ACT therapy delivered by REACT NeuroVR headset",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"BEHAVIORAL","ACT therapy delivered by REACT NeuroVR headset","This is ACT\u002Fmindfulness therapy delivered via a virtual reality headset.",[14],[26],{"name":27,"affiliation":28,"role":29},"carolyn bernstein, MD","BWH","PRINCIPAL_INVESTIGATOR",[31,35],{"name":27,"role":32,"phone":33,"phoneExt":12,"email":34},"CONTACT","6177329700","cabernstein@bwh.harvard.edu",{"name":36,"role":32,"phone":12,"phoneExt":12,"email":37},"asimina lazaridou, PhD","alazaridou@bwh.harvard.edu",[39,52,61],{"facility":40,"status":12,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":12},"Brigham and Womens Hospital","Boston","Massachusetts","02155","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-71.05977,42.35843,{"lat":50,"lon":49},{"facility":53,"status":12,"city":54,"state":42,"zip":55,"country":44,"countryCode":45,"cosmosGeoPoint":56,"geoPoint":60,"contacts":12},"Brigham and Women's Health Care Center","Chestnut Hill","02467",{"type":47,"coordinates":57},[58,59],-71.16616,42.33065,{"lat":59,"lon":58},{"facility":5,"status":12,"city":54,"state":42,"zip":55,"country":44,"countryCode":45,"cosmosGeoPoint":62,"geoPoint":64,"contacts":12},{"type":47,"coordinates":63},[58,59],{"lat":59,"lon":58},{"type":29,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Carolyn A. Bernstein","Lavine Family Endowed Chair in Neurology","100638204","using-virtual-reality-to-teach-mindfulness-to-people-with-migraine-100638204",false,"NCT07599228","Using Virtual Reality to Teach Mindfulness to People With Migraine","Migraine Intervention Using Reality-Assisted Guided Experience","MIRAGE","Inclusion Criteria:\n\n* Adults aged 18-80\n* Diagnosed with episodic migraine and experience 4-10 migraine days\u002Fmonth\n* On a stable dose of CGRP mAb for three months prior\n* Satisfy 4 week run-in of 4-10 headaches\u002Fmonth\n* Not taking other preventive medications\n* Not pregnant, breastfeeding, or planning to become pregnant within study timeframe\n* Able and willing to use VR device\n* No history of significant psychiatric illness\n* Willing to comply with study procedures\n* English-speaking\n\nExclusion Criteria:\n\n* Medication overuse (\\>10 days\u002Fmonth)\n* Vertigo\u002Fvestibular dysfunction\n* Active psychiatric or neurological comorbidities\n* Pregnancy, breastfeeding or planning pregnancy within study timeframe\n* Significant visual\u002Fhearing\u002Fmobility impairment affecting VR use","ALL","18 Years","80 Years",{"count":80,"type":81},160,"ESTIMATED","INTERVENTIONAL",[84],"NA","The aim of this clinical trial is to learn if people with migraine can learn a type of biobehavioral therapy called Acceptance and Commitment Therapy (ACT) by using a virtual reality headset. Researchers are studying if this type of mindfulness therapy helps to decrease migraine-related disability. Participants will be randomized to treatment as usual or active virtual reality groups for four weeks. Everyone will keep symptom diaries, complete surveys, attend two clinic visits, and have two blood draws.",[87,88,89,90],"Migraine Disorders","Migraine With Aura","Migraine Without Aura","Episodic Migraine",[92,93,94,95,96],"acceptance and commitment therapy (ACT)","migraine","virtual reality","mindfulness","Calcitonin Gene-Related Peptide monoclonal antibody therapy","NOT_YET_RECRUITING","2026-05-14",{"date":100,"type":101},"2026-05-20","ACTUAL",{"date":103,"type":81},"2026-07",{"date":105,"type":81},"2031-01",{"name":5,"class":6},3]