[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626979":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":49,"collaborators":18,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":18,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":18,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":74,"whyStopped":18,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Hackensack Meridian Health","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Lung Ultrasound (LUS)","EXPERIMENTAL","The lung ultrasound will be performed within 2 hours of life scanning 6 anatomic lung zones. The lung ultrasound (LUS) score will be calculated in a longitudinal and transverse scan by dividing each lung into 3 different areas: upper-anterior, lower-anterior, and lateral. Every lung section will be scored 0-3 points. The total LUS score will range from 0 to 18 points according to the severity of the lung pattern. Examinations will be performed in the supine position. Lung ultrasound scores will be performed by neonatologist-researchers. A LUS score of 6 in \\\u003C 28 week gestation and 8 in \\> 28 week gestation is the cut-off for initiating surfactant treatment. If the LUS score is \\> 6 in neonates \\\u003C 28 weeks gestation, or \\> 8 in those \\> 28 weeks gestation, surfactant treatment will be administered. If a neonate in the LUS group does not meet criteria for SRT based on the lung ultrasound score, SRT may be administered per the clinician's discretion at any time.",[13],"Diagnostic Test: Lung ultrasound",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of care (SOC)","NO_INTERVENTION","The standard of care group may have surfactant administered per clinician discretion. Standard diagnostic testing including CXR and blood gas will be performed per SOC. Current accepted practice in the NICU is to utilize a composite of chest x-ray interpretation, assessment of work of breathing, degree of respiratory support and FiO2 requirement (typically Fi02 35%) to guide SRT.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DIAGNOSTIC_TEST","Lung ultrasound","Lung ultrasounds informing the decision-making on the Surfactant Administration",[9],[26],{"name":27,"affiliation":5,"role":28},"Sandy Cheung, DO","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Jeanette Buljevich Haugh","CONTACT","5519963457","jeanette.haugh@hmhn.org",[36],{"facility":37,"status":18,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":18},"Hackensack Univeristy Medical Center","Hackensack","New Jersey","07601","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-74.04347,40.88593,{"lat":47,"lon":46},{"type":50,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100626979","utilization-of-lung-ultrasound-score-in-decision-for-minimally-invasive-surfactant-administration-100626979",false,"NCT07442669","Utilization of Lung Ultrasound Score in Decision for Minimally Invasive Surfactant Administration","Utilization of Lung Ultrasound Score in Decision for Minimally Invasive Surfactant Administration: A Pilot Study","Inclusion Criteria:\n\n* Inborn at 27 0\u002F7 to 34 6\u002F7 weeks of gestational age\n* Spontaneously breathing at birth but requiring non-invasive respiratory support\n* RDS diagnosed on chest x-ray (diffuse, bilateral, fine granular opacities in lungs, air bronchograms) or were at risk of developing RDS\n\nExclusion Criteria:\n\n* Outborn\n* Endotracheal intubation in the delivery room or within 2 hours of life\n* Surfactant in the delivery room as part of advanced resuscitation\n* Presence of major congenital malformations or chromosomal anomalies\n* Hydrops fetalis\n* Inherited disorders of metabolism\n* Air leak syndrome (pneumothorax, pneumomediastinum) prior to surfactant administration, congenital diaphragmatic hernia, congenital pneumonia, meconium aspiration syndrome\n* Infants in extremis not expected to survive","ALL","27 Weeks","34 Weeks",{"count":62,"type":63},100,"ESTIMATED","INTERVENTIONAL",[66],"NA","This prospective randomized controlled study aims to determine if using a lung ultrasound score can lead to a faster diagnosis of severe respiratory distress syndrome and quicker administration of surfactant in moderately and late-preterm infants. The research will involve 100 infants, with 67 in the prospective group and 33 serving as controls.\n\nThe primary goal is to shorten the time to treatment for these vulnerable newborns. The study will also assess whether this ultrasound-guided approach improves short-term respiratory outcomes. These secondary objectives include measuring any decrease in the need for and duration of mechanical ventilation, the length of non-invasive respiratory support, and the overall need for oxygen.\n\nThe study population includes infants born between 27 and 34 6\u002F7 weeks of gestation who are admitted to the NICU. Each participant will be monitored from birth until they are discharged or transferred. This research aligns with a growing body of evidence suggesting that lung ultrasound can be a valuable tool in neonatal care, potentially leading to earlier and more precise treatment for respiratory distress syndrome.",[69,70],"Respiratory Distress Syndrome, Newborn","Respiratory Distress Syndrome in Premature Infant",[72,22,73],"Respiratory Distress","Surfactant Administration","NOT_YET_RECRUITING","2026-05-20",{"date":77,"type":78},"2026-05-22","ACTUAL",{"date":80,"type":63},"2026-07-01",{"date":82,"type":63},"2028-07-05",{"name":5,"class":6},1]