[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100513955":3},{"organization":4,"armGroups":7,"interventions":36,"overallOfficials":42,"centralContacts":51,"locations":60,"responsibleParty":81,"collaborators":42,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":42,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":42,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":62,"whyStopped":42,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"Bambino Gesù Hospital and Research Institute","OTHER",[8,16,20,24,28,32],{"label":9,"type":10,"description":11,"interventionNames":12},"HD-tDCS V5\u002FMT, HD-tDCS V1, Sham","EXPERIMENTAL","1. Active HD-tDCS over V5\u002FMT\n2. Active HD-tDCS over V1\n3. Sham HD-tDCS over V5\u002FMT or V1",[13,14,15],"Device: Active HD-tDCS over V5\u002FMT","Device: Active HD-tDCS over V1","Device: Sham HD-tDCS over V5\u002FMT or V1",{"label":17,"type":10,"description":18,"interventionNames":19},"HD-tDCS V5\u002FMT, Sham, HD-tDCS V1","1. Active HD-tDCS over V5\u002FMT\n2. Sham HD-tDCS over V5\u002FMT or V1\n3. Active HD-tDCS over V1",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"HD-tDCS V1, HD-tDCS V5\u002FMT, Sham","1. Active HD-tDCS over V1\n2. Active HD-tDCS over V5\u002FMT\n3. Sham HD-tDCS over V5\u002FMT or V1",[13,14,15],{"label":25,"type":10,"description":26,"interventionNames":27},"HD-tDCS V1, Sham, HD-tDCS V5\u002FMT","1. Active HD-tDCS over V1\n2. Sham HD-tDCS over V5\u002FMT or V1\n3. Active HD-tDCS over V5\u002FMT",[13,14,15],{"label":29,"type":10,"description":30,"interventionNames":31},"Sham, HD-tDCS V5\u002FMT, HD-tDCS V1","1. Sham HD-tDCS over V5\u002FMT or V1\n2. Active HD-tDCS over V5\u002FMT\n3. Active HD-tDCS over V1",[13,14,15],{"label":33,"type":10,"description":34,"interventionNames":35},"Sham, HD-tDCS V1, HD-tDCS V5\u002FMT","1. Sham HD-tDCS over V5\u002FMT or V1\n2. Active HD-tDCS over V1\n3. Active HD-tDCS over V5\u002FMT",[13,14,15],[37,43,47],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"DEVICE","Active HD-tDCS over V5\u002FMT","For HD-tDCS a 4 × 1 montage (Kessler et al., 2013), small circular electrodes (diameter 1 cm) will be used with the anode placed centrally with a current intensity of 1 mA for a total of 20 minutes (30 s ramp up\u002Fdown). Hereby, the anodal electrode modulates the excitability of the targeted area left V5\u002FMT, whereas the other 4 electrodes return electrical currents that flow away from that area. V5\u002FMT will be localised via published procedures and electrode's placement will be done according to the 10-20 International EEG 10-20 System for electrode placement.",[21,25,9,17,33,29],null,{"type":38,"name":44,"description":45,"armGroupLabels":46,"otherNames":42},"Active HD-tDCS over V1","For HD-tDCS a 4 × 1 montage (Kessler et al., 2013), small circular electrodes (diameter 1 cm) will be used with the anode placed centrally with a current intensity of 1 mA for a total of 20 minutes (30 s ramp up\u002Fdown). Hereby, the anodal electrode modulates the excitability of the targeted area left V1, whereas the other 4 electrodes return electrical currents that flow away from that area. V1 will be localised via published procedures and electrode's placement will be done according to the 10-20 International EEG 10-20 System for electrode placement.",[21,25,9,17,33,29],{"type":38,"name":48,"description":49,"armGroupLabels":50,"otherNames":42},"Sham HD-tDCS over V5\u002FMT or V1","Sham HD-tDCS will be delivered over left V5\u002FMT or left V1. The same electrodes placement as well as the stimulation set-up will be used as in the active stimulation conditions, but the current will be applied for 30 s and will be ramped down (0 mA) during the rest of the session without the participants awareness. .",[21,25,9,17,33,29],[52,57],{"name":53,"role":54,"phone":55,"phoneExt":42,"email":56},"Deny Menghini","CONTACT","06.6859.2875","deny.menghini@opbg.net",{"name":58,"role":54,"phone":42,"phoneExt":42,"email":59},"Giulia Lazzaro","giulia.lazzaro@opbg.net",[61],{"facility":5,"status":62,"city":63,"state":42,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"RECRUITING","Roma","00165","Italy","IT",{"type":68,"coordinates":69},"Point",[70,71],11.10642,44.99364,{"lat":71,"lon":70},[74,75,79],{"name":53,"role":54,"phone":55,"phoneExt":42,"email":56},{"name":76,"role":54,"phone":77,"phoneExt":42,"email":78},"Rita Alparone","06.6859.2859","rita.alparone@opbg.net",{"name":53,"role":80,"phone":42,"phoneExt":42,"email":42},"PRINCIPAL_INVESTIGATOR",{"type":80,"investigatorFullName":53,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"Head of Psychology Unit","100513955","v5mt-stimulation-on-reading-and-reading-related-measures-in-developmental-dyslexia-100513955",false,"NCT05972200","V5\u002FMT Stimulation on Reading and Reading-related Measures in Developmental Dyslexia","Probing the Efficacy of V5\u002FMT Stimulation on Reading and Reading-related Measures in Children and Adolescents With Developmental Dyslexia","Inclusion Criteria:\n\n* Italian speakers right-handed children and adolescents with dyslexia (DSM-5, APA 2013);\n* Word\u002Fnonword\u002Ftext reading accuracy and\u002For speed at least 2 Standard Deviations below the mean for school-age;\n* nv IQ ≥ 85;\n* normal hearing and normal or corrected-to-normal vision.\n\nExclusion Criteria:\n\n* Having a comorbidity with other primary psychiatric\u002Fneurological diagnosis (e.g., depression, anxiety, autism, ADHD);\n* Having a personal history of neurological\u002Fmedical\u002Fgenetic diseases;\n* Having ongoing drug treatment influencing brain function;\n* Having epilepsy o family history of epilepsy.",true,"ALL","8 Years","13 Years",{"count":95,"type":96},36,"ESTIMATED","INTERVENTIONAL",[99],"NA","The present study grounds on the absence of evidence-based treatment in individuals with developmental dyslexia (DD). At this topic, the present study will explore the potential effect of transcranial direct current stimulation (tDCS) over left hemispheric direct Lateral Geniculate Nucleus (LGN)-V5\u002FMT pathway, cerebral areas usually disrupted in individuals with DD.\n\nThe investigators hypothesized that active tDCS over V5\u002FMT will boost reading skills in children and adolescents with DD. On the contrary, sham (placebo condition) tDCS over V5\u002FMT or active (control condition) tDCS over V1 will not have significant effect in improving reading skills. Further, both active and sham tDCS will be safe and well tolerated.",[102],"Developmental Dyslexia",[104,105,106,107,108,109,110,111,112],"Children","Adolescents","tDCS","transcranial direct current stimulation","neurodevelopmental disorders","non-invasive brain stimulation","transcranial electrical stimulation","EEG","reading abilities","2023-08-02",{"date":115,"type":116},"2023-08-04","ACTUAL",{"date":118,"type":96},"2023-09-01",{"date":120,"type":96},"2026-08-31",{"name":5,"class":6},1]