[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563157":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":14,"responsibleParty":33,"collaborators":7,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":45,"sex":46,"minAge":47,"maxAge":7,"enrollmentInfo":48,"targetDuration":7,"studyType":51,"phases":7,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":17,"whyStopped":7,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},{"fullName":5,"class":6},"University of Cologne","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Sibylle Mellinghoff, MD","CONTACT","+4947885523","sibylle.mellinghoff@uk-koeln.de",[15],{"facility":16,"status":17,"city":18,"state":19,"zip":20,"country":21,"countryCode":22,"cosmosGeoPoint":23,"geoPoint":28,"contacts":29},"University Hospital Cologne","RECRUITING","Cologne","North Rhine-Westphalia","50937","Germany","DE",{"type":24,"coordinates":25},"Point",[26,27],6.95,50.93333,{"lat":27,"lon":26},[30],{"name":31,"role":11,"phone":32,"phoneExt":7,"email":13},"Sibylle C Mellinghoff, MD","+4915901029684",{"type":34,"investigatorFullName":35,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Sibylle C Mellinghoff","Board certified medical doctor","100563157","vaccine-induced-immunity-in-immunocompromised-patients-100563157",false,"NCT06612515","Vaccine-induced Immunity in Immunocompromised Patients","Prospective Cohort-study for the Investigation of the Vac-cine-induced Immune Response After Vaccination Against RESPiratory Viral Infections in Immunocompromised Pa-tients With or Without Haemato-ONcological diseaSEs","RESPONSE","Inclusion Criteria:\n\n* Signed informed consent form\n* Patients with immunosuppression either by treatment or underlying diseases\n* Patients who are vaccinated or willing to be vaccinated against respiratory virus infections in ac-cordance with current recommendations\n* Age of 18 years or older\n\nExclusion Criteria:\n\n* Patients unwilling\u002Fineligible for vaccination under current recommendations",true,"ALL","18 Years",{"count":49,"type":50},1000,"ESTIMATED","OBSERVATIONAL","Managing respiratory virus infections in immunocompromised patients requires a multidisciplinary approach, including vaccination, though its effectiveness is often suboptimal in these individuals.\n\nIn hematological patients, poor humoral immunogenicity is common, especially when the B cell axis is affected by disease or treatment, while T cell responses may offer better protection. Current immunologic data on these patients is limited, focusing mostly on serologic parameters. To address this, we will conduct an observational study analyzing early and late booster vaccinations, with a focus on virus-specific T cell responses in vaccinated patients.",[54],"Immunodeficiency",[56],"vaccine; Immunocompromised; immune response","2026-05-11",{"date":59,"type":60},"2026-05-12","ACTUAL",{"date":62,"type":60},"2025-03-25",{"date":64,"type":50},"2029-12-31",{"name":5,"class":6},1]