[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567020":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":35,"responsibleParty":80,"collaborators":84,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":10,"studyType":104,"phases":10,"briefSummary":105,"conditions":106,"keywords":10,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"University of Cape Town","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy",null,"Cervicovaginal microbiota, mycobiota, and HPV prevalence, and identify women with stable Lactobacillus-dominated microbiota, with no STIs and no evidence of genital inflammation.",[13],"Diagnostic Test: None - observational study only",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","None - observational study only","No interventions, diagnostics tests for HIV, pregnancy, STIs and BV only",[9],[21],{"name":22,"affiliation":23,"role":24},"Brian R Kullin, PhD","Research Officer","STUDY_DIRECTOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Jo-Ann S Passmore, PhD","CONTACT","+27 78 421 2701","jo-ann.passmore@uct.ac.za",{"name":32,"role":28,"phone":33,"phoneExt":10,"email":34},"Tanya Pidwell, MSc Hons","+27 82 725 5159","tanya.pidwell@uct.ac.za",[36,59],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"KEMRI","RECRUITING","Kisumu","Kisumu County","40100","Kenya","KE",{"type":45,"coordinates":46},"Point",[47,48],34.76171,-0.10221,{"lat":48,"lon":47},[51,55],{"name":52,"role":28,"phone":53,"phoneExt":10,"email":54},"Serah Gitome, PhD","+254 721 422355","swgitome@gmail.com",{"name":56,"role":28,"phone":57,"phoneExt":10,"email":58},"Pauline Wekesa, MSc","+254 726 266031","weknasambu@gmail.com",{"facility":60,"status":38,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"Desmond Tutu Health Foundation","Cape Town","Western Cape","7975","South Africa","ZA",{"type":45,"coordinates":67},[68,69],18.42322,-33.92584,{"lat":69,"lon":68},[72,76],{"name":73,"role":28,"phone":74,"phoneExt":10,"email":75},"Anda Madikida","+27847588817","Anda.Madikida@hiv-research.org.za",{"name":77,"role":28,"phone":78,"phoneExt":10,"email":79},"Tanya Pidwell","+27827255159","tanyapidwell@gmail.com",{"type":81,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jo-An Passmore","Professor",[85,87],{"name":86,"class":6},"Desmond Tutu HIV Foundation",{"name":88,"class":6},"Kenya Medical Research Institute","100567020","vaginal-microbiome-research-consortium-for-africa-100567020",false,"NCT06662747","Vaginal Microbiome Research Consortium for Africa","Vaginal Microbiome Research Consortium for Africa - Pilot","VMRC4Africa","Inclusion Criteria:\n\n* Female at birth\n* Willing and able to provide informed consent for screening and cognitive ability to understand sampling procedures\n* Not pregnant\n* HIV negative on testing performed by study staff\n* 18-40 years old\n* Planning to stay in the area for the next 10 weeks\n* Able and willing to provide adequate locator information for study retention purposes\n* Willing and able to return for all 3 nurse visits and return self-swabs to the clinic weekly\n* Sexually active for the last 3 months defined as penetrative penile-vaginal intercourse at least once in the last 3 months\n\nExclusion Criteria:\n\n* Male at birth\n* Not willing to provide consent\n* Pregnant or actively trying to conceive\u002Fbecome pregnant in the next 10 weeks\n* Living with HIV or untreated STIs (CT, NG, TV) or bacterial vaginosis (Nugent \\> 3)\n* Currently taking antibiotics or having been on antibiotic treatment in the previous four weeks\n* \\\u003C18 or \\>40 years old\n* On chronic disease management for gynaecological conditions\n* Any medical condition or other factors which would preclude study participation as per principal Investigator's or designee's decision, including but not limited to cancer of the cervix\n* Any mental health condition which, in the opinion of the investigator, would preclude comprehension of informed consent, or preclude study participation\n* Currently enrolled on any other study prohibiting co-enrolment",true,"FEMALE","18 Years","40 Years",{"count":102,"type":103},200,"ESTIMATED","OBSERVATIONAL","1. To characterise vaginal microbial community dynamics (bacterial and fungal) from different geographies in Africa to understand the microbial diversity that occurs in women with stable L. crispatus-dominant versus unstable vaginal microbiota.\n2. To identify vaginal communities associated with low levels of inflammation in women from different geographies in Africa\n3. To examine prevalence and diversity of HPV types circulating in the different geographies and their interaction with the vaginal microbiota\n4. To create a biobank of stored samples that can be used in future studies and for the isolation of regionally representative bacterial strains.",[9],"2025-08-01",{"date":109,"type":110},"2025-08-03","ACTUAL",{"date":112,"type":110},"2021-10-15",{"date":114,"type":103},"2026-10-31",{"name":5,"class":6},2]