[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624763":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":50,"collaborators":26,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":26,"enrollmentInfo":64,"targetDuration":26,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":81,"whyStopped":26,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"The University of Texas Health Science Center, Houston","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Hysterectomy by vNOTES approach followed by uterosacral suspension","ACTIVE_COMPARATOR","Two suspension sutures will be placed on the uterosacral ligament on each side after the completion of the hysterectomy",[13,14],"Procedure: Uterosacral suspension","Procedure: Hysterectomy by vNOTES approach",{"label":16,"type":17,"description":18,"interventionNames":19},"Hysterectomy by vNOTES approach","PLACEBO_COMPARATOR","No additional intervention will be done following hysterectomy",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Uterosacral suspension","Placement of two suspension sutures on the uterosacral ligament on each side",[9],null,{"type":22,"name":16,"description":28,"armGroupLabels":29,"otherNames":26},"Hysterectomy with or without adnexectomy performed by vaginal natural orifice transluminal endoscopic surgery (vNOTES)",[16,9],[31],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Aya Mohr Sasson, MD","CONTACT","346-270-4682","aya.mohrsasson@uth.tmc.edu",[37],{"facility":38,"status":26,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":26},"University of Texas","Houston","Texas","77030","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-95.36327,29.76328,{"lat":48,"lon":47},{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Aya Mohr Sasson","Doctor","100624763","vaginal-natural-orifice-transluminal-endoscopic-vnote-hysterectomy-with-uterosacral-suspension-100624763",false,"NCT07413861","Vaginal Natural Orifice Transluminal Endoscopic (vNOTE) Hysterectomy With Uterosacral Suspension","VENUS","Inclusion Criteria:\n\n* Age\\>18\n* All women undergoing vNOTES hysterectomy ± Bilateral salpingectomy\u002Fsalpingo-oopherectomy for benign gynecological indication\n\nExclusion Criteria:\n\n* Exclusion for vNOTES surgery: pelvic inflammatory disease, previous rectal surgery, suspected malignancy, radiation\n* Indication for surgery: elvic prolapse\n* Other surgical interventions planned for the procedure",true,"FEMALE","18 Years",{"count":65,"type":66},50,"ESTIMATED","INTERVENTIONAL",[69],"NA","As the adoption of Vaginal natural orifice transluminal endoscopic surgery (vNOTES) expands, attention is shifting from feasibility studies to the refinement of surgical steps that optimize long-term pelvic health.\n\nOne technical distinction between vNOTES hysterectomy and conventional laparoscopic or robotic hysterectomy is the routine early transection of the uterosacral ligaments as the approach is caudal-cephalic. These ligaments are not merely anatomic landmarks-they are the primary apical support structures of the vagina, anchoring the vaginal cuff to the sacrum and providing resistance against downward displacement. Disruption of this support can predispose patients to apical vaginal prolapse, a condition that significantly affects quality of life and may require complex reconstructive surgery.\n\nUterosacral ligament suspension (USLS) is a well-established, effective method of restoring apical support at the time of hysterectomy. Incorporating uterosacral suspension into vNOTES hysterectomy is a logical evolution toward ensuring that minimally invasive innovation does not come at the expense of long-term pelvic health. By adapting and standardizing this reconstructive step for vNOTES, surgeons can maintain apical support, reduce future prolapse risk, and uphold the same quality benchmarks established in laparoscopic and vaginal surgery.\n\nOBJECTIVE AND HYPOTHESIS:\n\nThis study aims to present a practical, reproducible technique for performing USLS in the vNOTES setting and to evaluate its potential immediate benefits, possible complication rates, and additional operative time compared with vNOTES hysterectomy without USLS. In doing so, we seek to demonstrate that preventive pelvic support can be seamlessly integrated without compromising the efficiency or advantages of the transvaginal endoscopic approach.",[72,73],"Prolapse Pelvic","Hysterectomy",[75,76,77,78,79,80],"hysterectomy","prevention","pelvic prolapse","uterosacral suspension","vaginal surgery","vaginal natural orifice transluminal surgery","NOT_YET_RECRUITING","2026-02-12",{"date":84,"type":85},"2026-02-17","ACTUAL",{"date":87,"type":66},"2026-03-01",{"date":89,"type":66},"2027-12-01",{"name":5,"class":6},1]