[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621294":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":56,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Istanbul University - Cerrahpasa","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"transcutaneous Vagus Nerve Stimulation (tVNS) plus exercises","EXPERIMENTAL","the interventional group will receive active tVNS plus exercise therapy including traditional exercises and home exercises.",[13],"Other: Active tVNS plus exercises",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham controlled tVNS plus exercises","SHAM_COMPARATOR","the control group will receive Sham-controlled tVNS plus exercise therapy including traditional exercises and home exercises.",[19],"Other: Sham controlled tVNS plus exercises",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Active tVNS plus exercises","This program will be performed 3 times per week for 6 weeks. Each session will include 30 minutes of tVNS. Stimulation will be delivered to the auricular branch of the vagus nerve using a non-invasive transcutaneous device. Electrodes will be placed on the tragus and concha regions of the ear. in addition to traditional exercises including mobilization, ROM exercises, stretching and strengthening exercises.",[9],null,{"type":6,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"This program will be performed three times per week for six weeks. In each session, 30 minutes of sham tVNS will be applied, during which the device will remain inactive, in addition to traditional exercise therapy including joint mobilization, range of motion exercises, stretching, and strengthening exercises.",[15],[30],{"name":31,"affiliation":5,"role":32},"Salam Alruz, Msc","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Salam Alruz, MSc","CONTACT","+90 5510805265","salamalruz@gmail.com",[40],{"facility":41,"status":42,"city":43,"state":25,"zip":25,"country":44,"countryCode":25,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Istanbul University-Cerrahpaşa","RECRUITING","Istanbul","Turkey (Türkiye)",{"type":46,"coordinates":47},"Point",[48,49],28.94966,41.01384,{"lat":49,"lon":48},[52,53],{"name":31,"role":36,"phone":37,"phoneExt":25,"email":38},{"name":54,"role":55,"phone":25,"phoneExt":25,"email":25},"Derya Çelik","SUB_INVESTIGATOR",{"type":32,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Salam Alruz","Principal Investigator","100621294","vagus-nerve-stimulation-effect-in-frozen-shoulder-treatment-100621294",false,"NCT07368751","Vagus Nerve Stimulation Effect in Frozen Shoulder Treatment","Clinical Effects of Transcutaneous Vagus Nerve Stimulation in the Treatment of Frozen Shoulder: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 40 and 65 years.\n* Less than 50% range of motion compared with the contralateral shoulder in at least one movement (external rotation, abduction, flexion, or internal rotation).\n* More than 25% loss of range of motion in at least two movement planes compared with the unaffected shoulder.\n* Increasing limitation of glenohumeral external and internal rotation during abduction from 45° to 90°.\n* Shoulder pain lasting at least 3 months during activities of daily living.\n\nExclusion Criteria:\n\n* Passive joint range of motion within normal limits\n* External rotation range of motion \\\u003C30°\n* Radiographic evidence of glenohumeral arthritis\n* Presence of inflammatory joint disease\n* Previous treatment related to the current shoulder complaint (physiotherapy and rehabilitation, intra-articular injection, or surgery)\n* Pain intensity \\\u003C3 according to the Numerical Pain Rating Scale (NPRS)\n* Presence of neurological deficits, cardiac disease, neuropathic disorders, or pregnancy","ALL","40 Years","65 Years",{"count":70,"type":71},40,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this clinical trial is to learn if the addition of transcutaneous vagus nerve stimulation (tVNS) to exercise is effective in improving pain, shoulder function, shoulder range of motion, and psychological factors in adults with frozen shoulder.\n\nThe main questions this study aims to answer are:\n\nDoes adding tVNS to exercise reduce shoulder pain ? Does adding tVNS to exercise improve shoulder function and shoulder range of motion? Does adding tVNS to exercise improve psychological factors ? Does adding tVNS to exercise improve patient satisfaction?\n\nResearchers will compare the effect of active tVNS added to exercise with sham-controlled tVNS added to exercise to determine whether adding tVNS provides additional benefits in the management of frozen shoulder.\n\nParticipants will:\n\nReceive active tVNS plus exercise therapy or sham-controlled tVNS plus exercise therapy.\n\nAttend supervised rehabilitation sessions 3 times per week for 6 weeks. Perform a home exercise program as instructed by the study physiotherapist.",[77],"Frozen Shoulder",[77,79,80],"Vagus Nerve Stimulation","Exercise","2026-02-02",{"date":83,"type":84},"2026-02-04","ACTUAL",{"date":81,"type":84},{"date":87,"type":71},"2027-03-01",{"name":5,"class":6},1]