[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642527":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":35,"centralContacts":39,"locations":45,"responsibleParty":67,"collaborators":30,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":30,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":30,"enrollmentInfo":80,"targetDuration":30,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":48,"whyStopped":30,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Pre-Post Group (P-P)","EXPERIMENTAL","This group will undergo taVNS for up to 6 weeks before and for 3 months following surgery",[13],"Device: Vagus nerve stimulation (taVNS)",{"label":15,"type":10,"description":16,"interventionNames":17},"Post Group","This group will undergo sham stimulation for up to 6 weeks before surgery. They will receive taVNS for 3 months after surgery",[13,18],"Device: Sham Stimulation",{"label":20,"type":21,"description":22,"interventionNames":23},"Sham Group","SHAM_COMPARATOR","This group will undergo sham stimulation for up to 6 weeks before surgery and for 3 months after surgery. The patients will not know they are not receiving stimulation.",[18],[25,31],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Vagus nerve stimulation (taVNS)","Vagus nerve stimulation - clip is attached to ear",[15,9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Sham Stimulation","Clip will be attached to the ear, but no stimulation will be given.",[15,20],[36],{"name":37,"affiliation":5,"role":38},"Wilson Z Ray, MD","PRINCIPAL_INVESTIGATOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Linda Koester, BS","CONTACT","314-362-7368","koesterl@wustl.edu",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Washington University","RECRUITING","St Louis","Missouri","63110","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-90.19789,38.62727,{"lat":58,"lon":57},[61,63,65],{"name":62,"role":42,"phone":43,"phoneExt":30,"email":44},"Linda Z Koester, BS",{"name":37,"role":42,"phone":30,"phoneExt":30,"email":64},"rayz@wustl.edu",{"name":66,"role":38,"phone":30,"phoneExt":30,"email":30},"Wilson Z. Ray, MD",{"type":38,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Wilson Z. Ray","MD - Principal Investigator","100642527","vagus-nerve-stimulation-for-myelopathy-100642527",false,"NCT07660250","Vagus Nerve Stimulation for Myelopathy","Vagus Nerve Stimulation to Improve Post-operative Outcomes of Degenerative Cervical Myelopathy","Inclusion Criteria:\n\n* 18 years of age or older\n* Moderate or severe degenerative cervical myelopathy according to the mJOA\n* Decompression surgery planned\n\nExclusion Criteria:\n\n* • Pregnancy\n\n  * Electrically active implants (e.g. pacemaker)\n  * Known diagnosis of amyotrophic lateral sclerosis, multiple sclerosis, rheumatoid arthritis, concomitant thoracic and\u002For lumbar stenosis, spine tumor, HIV-related myelopathy\n  * Ongoing cancer therapy\n  * Ongoing use of immunomodulating or suppressive medication\n  * Sustained bradycardia with a heartrate \\\u003C50 beats per minute for \\> 5 minutes following admission.\n  * Prior cervical spine surgery",true,"ALL","18 Years",{"count":81,"type":82},36,"ESTIMATED","INTERVENTIONAL",[85],"NA","The objective of this study is to generate preliminary data to establish the feasibility and effectiveness of transauricular vagus nerve stimulation (taVNS) to improve post-operative outcomes of moderate to severe degenerative cervical myelopathy (DCM)",[88],"Degenerative Cervical Myelopathy",[90,91,92,93,94,95,96],"degenerative cervical myelopathy","myelopathy","cervical myelopathy","degenerative myelopathy","vagus nerve","vagus nerve stimulation","ear stimulation","2026-06-15",{"date":99,"type":100},"2026-06-22","ACTUAL",{"date":102,"type":100},"2026-04-14",{"date":104,"type":82},"2028-05",{"name":5,"class":6},1]