[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552675":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":59,"collaborators":24,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":24,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":24,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":83,"overallStatus":42,"whyStopped":24,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Petrovsky National Research Centre of Surgery","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group","EXPERIMENTAL","A group of patients whose postoperative period proceeded without complications, in connection with which they were transferred to the specialized department within 1-2 days.",[13],"Diagnostic Test: Determination of the level of the studied biomarkers",{"label":15,"type":10,"description":16,"interventionNames":17},"Group of patients with complications","Patients who had postoperative complications: pneumonia, wound infection, sepsis, multiple organ dysfunction.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Determination of the level of the studied biomarkers","Determination of the level of hematological indices based on a general blood test; Determination of the levels of the following biomarkers: isolation of neutrophils from the blood using the gradient centrifugation method; assessment using enzyme immunoassay (ELISA) of the content of neutrophil elastase in the supernatant; myeloperoxidase, ELISA; lactoferrin, ELISA; interleukin -1ß,17,10,6, ELISA; presepsin, ELISA; endothelin, ELISA; lipopolysaccharide, LAL test; lipopolysaccharide binding protein, ELISA; NETs release, immunofluorescence method; the number of neutrophils expressing PDL-1, flow cytofluorimetry method; procalcitonin in human plasma and serum, VIDAS B.R.A.H.M.S. PCT; ferritin, reagent for determination (FERRITIN); lactate dehydrogenase, reagent for determination of QSR6128;Endotoxin Activity Assay, chemiluminescent immunodiagnostics.",[9,15],null,[26],{"name":27,"affiliation":28,"role":29},"Maxim A. Babaev, D.M.","Petrovsky NRCS","PRINCIPAL_INVESTIGATOR",[31,35],{"name":27,"role":32,"phone":33,"phoneExt":24,"email":34},"CONTACT","89160269066","maxbabaev@mail.ru",{"name":36,"role":32,"phone":37,"phoneExt":24,"email":38},"Oxana O. Grin","89168748565","grin_oksana@mail.ru",[40],{"facility":41,"status":42,"city":43,"state":24,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Petrovsky National Reasearch Centre of Surgery","RECRUITING","Moscow","119991","Russia","RU",{"type":48,"coordinates":49},"Point",[50,51],37.61781,55.75204,{"lat":51,"lon":50},[54,57],{"name":55,"role":32,"phone":56,"phoneExt":24,"email":38},"OXANA GRIN'","89168748586",{"name":58,"role":32,"phone":33,"phoneExt":24,"email":34},"MAXIM BABAEV, D.М.Sc.",{"type":60,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100552675","validation-of-hematological-indices-100552675",false,"NCT06476171","Validation of Hematological Indices","Validation of Hematological Indices as Prognostic Markers of Inflammatory Complications and Multiple Organ Dysfunction in Cardiac Surgery Patients.","Inclusion Criteria:\n\n* age from 18 to 80 years\n* cardiac surgery\n* operation in the conditions of cardiopulmonary bypass\n* availability of voluntary informed consent of the patient to participate in the study\n\nExclusion Criteria:\n\n* refusal of the patient from the study\n* transfer of the patient to another medical institution","ALL","18 Years","80 Years",{"count":72,"type":73},200,"ESTIMATED","INTERVENTIONAL",[76],"NA","The hypothesis of the study is that hematological indices (neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and systemic index of inflammation) may be predictors of infectious complications and multiple organ dysfunction in patients after cardiac surgery.",[79,80,81,82],"Multiple Organ Dysfunction","Sepsis","Pneumonia","Wound Infection",[79,80,84,85],"cardiac surgery","hematological indices","2024-11-20",{"date":88,"type":89},"2024-11-25","ACTUAL",{"date":91,"type":89},"2023-06-19",{"date":93,"type":73},"2025-12-30",{"name":5,"class":6},1]