[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581803":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":21,"responsibleParty":161,"collaborators":163,"id":177,"slug":178,"hasResults":179,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":183,"eligibilityCriteria":184,"healthyVolunteers":179,"sex":185,"minAge":186,"maxAge":187,"enrollmentInfo":188,"targetDuration":10,"studyType":191,"phases":10,"briefSummary":192,"conditions":193,"keywords":196,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":210},{"fullName":5,"class":6},"European Foundation for Study of Chronic Liver Failure","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with Decompensated Liver Cirrhosis",null,"Patients eligible for this study will be patients with decompensated cirrhosis expected to be discharged from the hospital within 48 hours after an index admission for AD according to the EASL-CLIF criteria",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Anna Bosch","CONTACT","+34 93 227 14 03","anna.bosch@efclif.com",{"name":19,"role":15,"phone":10,"phoneExt":10,"email":20},"Cristina Sánchez-Garrido","cristina.sanchez@efclif.com",[22,42,58,72,89,103,119,130,144],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":26,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Hospital Beaujon","RECRUITING","Clichy","France","92110","FR",{"type":30,"coordinates":31},"Point",[32,33],2.30952,48.90018,{"lat":33,"lon":32},[36,39],{"name":37,"role":15,"phone":10,"phoneExt":10,"email":38},"Pierre Emmanuel Rautou, PI","perautou@yahoo.fr",{"name":40,"role":41,"phone":10,"phoneExt":10,"email":10},"Pierre-Emmanuel Rautou","PRINCIPAL_INVESTIGATOR",{"facility":43,"status":24,"city":44,"state":45,"zip":46,"country":45,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":52,"contacts":53},"University Hospital, Aachen","Aachen","Germany","52074","DE",{"type":30,"coordinates":49},[50,51],6.08342,50.77664,{"lat":51,"lon":50},[54,57],{"name":55,"role":15,"phone":10,"phoneExt":10,"email":56},"Tony Bruns","tbruns@ukaachen.de",{"name":55,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":59,"status":24,"city":60,"state":45,"zip":61,"country":45,"countryCode":47,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Universitätsklinikum Münster","Münster","48149",{"type":30,"coordinates":63},[64,65],7.62571,51.96236,{"lat":65,"lon":64},[68,71],{"name":69,"role":15,"phone":10,"phoneExt":10,"email":70},"Jonel Trebicka","Jonel.Trebicka@ukmuenster.de",{"name":69,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":73,"status":24,"city":74,"state":75,"zip":76,"country":77,"countryCode":78,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di S.Orsola","Bologna","Italia","40138","Italy","IT",{"type":30,"coordinates":80},[81,82],11.33875,44.49381,{"lat":82,"lon":81},[85,88],{"name":86,"role":15,"phone":10,"phoneExt":10,"email":87},"Paolo Caraceni","paolo.caraceni@unibo.it",{"name":86,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":90,"status":24,"city":91,"state":77,"zip":92,"country":77,"countryCode":78,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"A.O.U. Città della Salute e della Scienza di Torino","Torino","10126",{"type":30,"coordinates":94},[95,96],11.99138,44.88856,{"lat":96,"lon":95},[99,102],{"name":100,"role":15,"phone":10,"phoneExt":10,"email":101},"Carlo Alessandria","carloalessandria@libero.it",{"name":100,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":104,"status":24,"city":105,"state":106,"zip":107,"country":106,"countryCode":108,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Hospital Universitari Vall d'Hebron Research Institute","Barcelona","Spain","08035","ES",{"type":30,"coordinates":110},[111,112],2.15899,41.38879,{"lat":112,"lon":111},[115,118],{"name":116,"role":15,"phone":10,"phoneExt":10,"email":117},"Joan Genescà","joan.genesca@vallhebron.cat",{"name":116,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":120,"status":24,"city":105,"state":106,"zip":121,"country":106,"countryCode":108,"cosmosGeoPoint":122,"geoPoint":124,"contacts":125},"Hospital Clinic de Barcelona","08036",{"type":30,"coordinates":123},[111,112],{"lat":112,"lon":111},[126,129],{"name":127,"role":15,"phone":10,"phoneExt":10,"email":128},"Javier Fernandez","JFDEZ@clinic.cat",{"name":127,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":131,"status":24,"city":132,"state":106,"zip":133,"country":106,"countryCode":108,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"Hospital Universitario Ramon y Cajal","Madrid","28034",{"type":30,"coordinates":135},[136,137],-3.70256,40.4165,{"lat":137,"lon":136},[140,143],{"name":141,"role":15,"phone":10,"phoneExt":10,"email":142},"Agustin Albillos","agustin.albillos@uah.es",{"name":141,"role":41,"phone":10,"phoneExt":10,"email":10},{"facility":145,"status":146,"city":147,"state":148,"zip":149,"country":148,"countryCode":150,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"Royal Free Hospital","NOT_YET_RECRUITING","London","United Kingdom","NW3 2QG","UK",{"type":30,"coordinates":152},[153,154],-0.12574,51.50853,{"lat":154,"lon":153},[157,160],{"name":158,"role":15,"phone":10,"phoneExt":10,"email":159},"Raj Mookerjee","r.mookerjee@ucl.ac.uk",{"name":158,"role":41,"phone":10,"phoneExt":10,"email":10},{"type":162,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[164,166,168,169,171,172,174,175],{"name":165,"class":6},"Universität Münster",{"name":167,"class":6},"IRCCS Azienda Ospedaliero-Universitaria di Bologna",{"name":104,"class":6},{"name":170,"class":6},"Hospital Clinic of Barcelona",{"name":131,"class":6},{"name":173,"class":6},"Beaujon Hospital",{"name":43,"class":6},{"name":176,"class":6},"A.O.U. Città della Salute e della Scienza","100581803","validation-of-new-prognostic-biomarkers-in-patients-with-decompensated-cirrhosis-100581803",false,"NCT06855056","Validation of New Prognostic Biomarkers in Patients With Decompensated Cirrhosis","Validation of New Prognostic biomarkerRs in Patients With cirrhOsis diScharged After a hosPitalization Due to acutE deCompensation or acuTe-on-chronic Liver Failure","PROSPECT","Inclusion Criteria:\n\n1. Age between 18 and 80 years.\n2. Patients with decompensated cirrhosis admitted to hospital due to AD according to the EASL-CLIF criteria (rapid onset of ascites, hepatic encephalopathy, portal hypertensive- related gastrointestinal bleeding, bacterial infection, or any combination of these), including those who presented ACLF during hospitalization.\n3. Recovery from AD and expected to be discharged within the next 48 hours.\n\nExclusion Criteria:\n\n1. Admission for planned diagnostic or therapeutic procedures\n2. Active malignancy (except for hepatocellular carcinoma within the Milan criteria or nonmelanocytic skin cancer)\n3. Antiviral treatment for hepatitis C, B and delta initiated in the last 6 months or planned to be initiated in the following 6 months.\n4. HIV positive (except undergoing treatment and who do not exhibit clinical manifestations of AIDS).\n5. Ongoing alcohol use disorder with an expected low adherence to prescriptions as judged by physician\n6. Previous liver or other organ transplantation\n7. Patients with TIPS or other surgical porto-caval shunts\n8. Chronic organic renal failure stage IV and V or estimated Glomerular Filtration Rate \\\u003C20 ml\u002Fmin according to the MDRD equations\n9. Chronic heart failure NYHA class III or IV\n10. Pulmonary disease GOLD III or IV\n11. Patients with a history of significant extrahepatic disease with life expectancy \\\u003C6 months\n12. Severe psychiatric disorders\n13. Pregnancy and breast-feeding\n14. Expected low adherence to study protocol as judged by physician\n15. Patients who cannot provide written informed consent or refuse to participate","ALL","18 Years","80 Years",{"count":189,"type":190},189,"ESTIMATED","OBSERVATIONAL","The study aims to test the effectiveness of new biomarkers (measurable molecules in our body) in predicting the health outcome of patients with liver cirrhosis discharged from the hospital after a serious complication of the disease",[194,195],"Liver Cirrhosis","Decompensated Cirrhosis of Liver",[197,198,199,194,200],"Decompensated Liver Cirrhosis","Acute on Chronic Liver Failure (ACLF)","Liver Diseases","Biomarkers","2025-08-05",{"date":203,"type":204},"2025-08-06","ACTUAL",{"date":206,"type":204},"2025-03-01",{"date":208,"type":190},"2026-09-30",{"name":5,"class":6},9]