[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601955":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":37,"locations":43,"responsibleParty":59,"collaborators":10,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":75,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":86,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Peking University Third Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"model-stratified group",null,"Patient receiving treatment in accord with stratified result of the established model.",[13],"Procedure: Model-guided adjuvant treatment",{"label":15,"type":10,"description":16,"interventionNames":17},"non-model-stratified group","Patient receiving treatment not in accord with stratified result of the established model.",[18],"Procedure: No adjuvant treatment",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Model-guided adjuvant treatment","Initiation of standard adjuvant treatment within 12 weeks after surgery.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"No adjuvant treatment","No initiation of adjuvant ICIs, radiotherapy, or targeted therapy at any point during follow-up prior to disease progression.",[15],[30,34],{"name":31,"affiliation":32,"role":33},"Yongyue Wei, master","Peking University Health Science Center","STUDY_DIRECTOR",{"name":35,"affiliation":5,"role":36},"Shudong Zhang, master","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":10,"email":42},"Jiyuan Chen, master","CONTACT","+086 18801430995","chenjiyuan@pku.edu.cn",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Beijing","Beijing Municipality","100191","China","CN",{"type":52,"coordinates":53},"Point",[54,55],116.39723,39.9075,{"lat":55,"lon":54},[58],{"name":39,"role":40,"phone":41,"phoneExt":10,"email":42},{"type":60,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100601955","validation-of-rcc-predicting-model-with-emulated-target-trial-100601955",false,"NCT07117227","Validation of RCC Predicting Model With Emulated-target Trial","Emulated-target Trial for Guiding Stratified Treatment for Renal Cell Carcinoma With Venous Tumor Thrombus","RCCETT","Inclusion Criteria:\n\n* Adults ≥18 years of age;\n* Diagnosis of primary renal cell carcinoma before and during the surgery;\n* Received radical nephrectomy\u002Fnephron-sparing surgery.\n\nExclusion Criteria:\n\n* Subjects with severely missing clinical information;\n* History of other malignant tumors.\n* Recurrence observed before first postoperative follow-up.\n* Discontinue the adjuvant treatment within in the first two course because of severe adverse react.","ALL","18 Years","80 Years",{"count":73,"type":74},4700,"ESTIMATED","2 Years","OBSERVATIONAL","This single-center study utilizes real-world data (2012-2024) from 4700 renal cell carcinoma (RCC) patients at Peking University Third Hospital to: (1) Develop and validate a prognostic prediction model specifically for RCC patients, including those with venous tumor thrombus (VTT); (2) Compare the performance of this new model against existing RCC prediction models in both the overall RCC cohort and the VTT subgroup; (3) Employ an emulated target trial (ETT) methodology to evaluate whether risk-stratified treatment based on the prediction model (grouping patients as high\u002Fmedium\u002Flow risk) improves survival outcomes .",[79,80,81,82,83,84,85],"Renal Cell Carcinoma (Kidney Cancer)","Renal Cell Carcinoma (RCC)","Tumor Thrombus","Prognosis","Prognostic Cancer Model","Real World Study","Observational Study",[87,88,89,90],"renal cell carcinoma","tumor thrombus","prognostic model","emulated-target trial","2026-04-08",{"date":93,"type":94},"2026-04-14","ACTUAL",{"date":96,"type":94},"2025-09-01",{"date":98,"type":74},"2027-08-01",{"name":5,"class":6},1]