[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100491364":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":20,"centralContacts":24,"locations":30,"responsibleParty":45,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":10,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},{"fullName":5,"class":6},"National Taiwan University Hospital","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"NTM-LD",null,"Diagnosis is made on the basis of the guidelines produced by the American Thoracic Society . Briefly, Patients have pulmonary symptoms with identified chest image and fit with the microbiology criteria.",{"label":13,"type":10,"description":14,"interventionNames":10},"NTM pulmonary colonizers and others","Those without fulfilling the diagnostic criteria but having at least one set of positive sputum for MAC or patients infected with NTM other than MAC species.",{"label":16,"type":10,"description":17,"interventionNames":10},"Pulmonary tuberculosis (TB)","Those with respiratory specimen culture positive for Mycobacterium tuberculosis or typical TB pulmonary pathology.",{"label":19,"type":10,"description":19,"interventionNames":10},"Healthy control",[21],{"name":22,"affiliation":5,"role":23},"Chin-Chung Shu","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":28,"email":29},"CONTACT","+886-2312-3456","53087","ccshu@ntu.edu.tw",[31],{"facility":5,"status":32,"city":33,"state":10,"zip":10,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Taipei","Taiwan","TW",{"type":37,"coordinates":38},"Point",[39,40],121.52639,25.05306,{"lat":40,"lon":39},[43],{"name":22,"role":26,"phone":44,"phoneExt":10,"email":10},"+886223123456",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100491364","validation-of-soluble-programmed-death-1-in-predicting-progression-of-nodular-bronchiectatic-form-of-nontuberculous-mycobacterial-lung-disease-a-multi-country-research-100491364",false,"NCT05678166","Validation of Soluble Programmed Death-1 in Predicting Progression of Nodular-bronchiectatic Form of Nontuberculous Mycobacterial Lung Disease: a Multi-Country Research","Inclusion Criteria:\n\n* Age ≥ 20 years\n* NTM-LD: (N=250) Diagnosis is made on the basis of the guidelines produced by the American Thoracic Society.Patients have pulmonary symptoms with identified chest image and fit with the microbiology criteria.\n* NTM pulmonary colonizers and others: (N=100) Those without fulfilling the diagnostic criteria but having at least one set of positive sputum for MAC or patients infected with NTM other than MAC species.\n* Pulmonary tuberculosis (TB): (N=100) Those with respiratory specimen culture positive for Mycobacterium tuberculosis or typical TB pulmonary pathology.\n* Healthy control (N=50)\n\nExclusion Criteria:\n\n* Patients who have acquired immunodeficiency syndrome",true,"ALL","20 Years",{"count":57,"type":58},500,"ESTIMATED","OBSERVATIONAL","The incidence of nontuberculous mycobacterial lung disease (NTM-LD) is increasing worldwide and in Eastern Asia. NTM-LD leads significant morbidity and mortality, around 25% within 5 years, but the treatment rate is low because the course of NTM-LD is indolent, especially in nodular-bronchiectatic (NB) form. However, there is no biomarker proven for predicting the progression in NB form of NTM-LD. Recently, it has been reported that the ratio of membrane-form programmed death-1 (PD-1) expressed T cells increased in patients with NTM-LD and it was associated with disease severity and progression. The mechanism has been speculated as a \"immune exhaustion\". In contrast to PD-1 expressed in cell membrane, soluble-form PD-1 is another biomarker that can be easily detected in serum. We recently reported that soluble PD-1 significantly correlated with cavitary lesion and disease progression in patients with NB-form NTM-LD in Taiwan. However, this has not been validated in other countries and ethnicities. Furthermore, the usefulness of soluble PD-1 in diagnosis and predicting mortality warrants further studies.",[62],"Nontuberculous Mycobacterial Lung Disease","2026-06-07",{"date":65,"type":66},"2026-06-10","ACTUAL",{"date":68,"type":66},"2023-01-31",{"date":70,"type":58},"2026-12-31",{"name":5,"class":6},1]