[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100296434":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":22,"responsibleParty":309,"collaborators":311,"id":359,"slug":360,"hasResults":361,"nctId":362,"briefTitle":363,"officialTitle":363,"acronym":364,"eligibilityCriteria":365,"healthyVolunteers":361,"sex":366,"minAge":367,"maxAge":7,"enrollmentInfo":368,"targetDuration":371,"studyType":372,"phases":7,"briefSummary":373,"conditions":374,"keywords":7,"overallStatus":25,"whyStopped":7,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":384,"locationsCount":385},{"fullName":5,"class":6},"Monash University","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Eric Morand","STUDY_CHAIR",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Eric F Morand","CONTACT","+ 61 3 8572 2650","eric.morand@monash.edu",{"name":19,"role":15,"phone":20,"phoneExt":7,"email":21},"Rangi K KANDANE-RATHNAYAKE","+ 61 3 8572 2561","Rangi.Kandane-Rathnayake@monash.edu",[23,41,49,67,80,99,113,124,139,156,169,182,197,210,224,232,246,261,280,293],{"facility":24,"status":25,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Rheumatology Unit, Royal Adelaide Hospital","RECRUITING","Adelaide","South Australia","5000","Australia","AU",{"type":32,"coordinates":33},"Point",[34,35],138.59863,-34.92866,{"lat":35,"lon":34},[38],{"name":39,"role":15,"phone":7,"phoneExt":7,"email":40},"Fiona Goldblatt","Fiona.Goldblatt@health.sa.gov.au",{"facility":42,"status":25,"city":26,"state":27,"zip":43,"country":29,"countryCode":30,"cosmosGeoPoint":44,"geoPoint":46,"contacts":47},"Department of Rheumatology, Flinders Medical Centre","5042",{"type":32,"coordinates":45},[34,35],{"lat":35,"lon":34},[48],{"name":39,"role":15,"phone":7,"phoneExt":7,"email":40},{"facility":50,"status":25,"city":51,"state":52,"zip":53,"country":29,"countryCode":30,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing & Health Sciences","Clayton","Victoria","3168",{"type":32,"coordinates":55},[56,57],145.11667,-37.91667,{"lat":57,"lon":56},[60,61,64],{"name":10,"role":15,"phone":7,"phoneExt":7,"email":17},{"name":62,"role":15,"phone":7,"phoneExt":7,"email":63},"Alberta Hoi","alberta.hoi@monash.edu",{"name":65,"role":66,"phone":7,"phoneExt":7,"email":7},"Vera Golder","SUB_INVESTIGATOR",{"facility":68,"status":25,"city":69,"state":52,"zip":70,"country":29,"countryCode":30,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Department of Rheumatology, St Vincent's Hospital (Melbourne)","Fitzroy","3065",{"type":32,"coordinates":72},[73,74],144.97833,-37.79839,{"lat":74,"lon":73},[77],{"name":78,"role":15,"phone":7,"phoneExt":7,"email":79},"Mandana Nikpour","m.nikpour@unimelb.edu.au",{"facility":81,"status":25,"city":82,"state":83,"zip":84,"country":85,"countryCode":86,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Department of Rheumatology and Immunology, People's Hospital Peking University Health Science Center","Beijing","Western District","100044","China","CN",{"type":32,"coordinates":88},[89,90],116.39723,39.9075,{"lat":90,"lon":89},[93,96],{"name":94,"role":15,"phone":7,"phoneExt":7,"email":95},"Zhan Guo Li","li99@bjmu.edu.cn",{"name":97,"role":15,"phone":7,"phoneExt":7,"email":98},"Yuan An","anyfield@163.com",{"facility":100,"status":25,"city":82,"state":101,"zip":102,"country":85,"countryCode":86,"cosmosGeoPoint":103,"geoPoint":105,"contacts":106},"Rheumatology and Immunology department, Peking University First Hospital","Xicheng District","100034",{"type":32,"coordinates":104},[89,90],{"lat":90,"lon":89},[107,110],{"name":108,"role":15,"phone":7,"phoneExt":7,"email":109},"Zhuoli Zhang","zhuoli.zhang@126.com",{"name":111,"role":15,"phone":7,"phoneExt":7,"email":112},"Yanjie Hao","hyjbb@163.com",{"facility":114,"status":115,"city":116,"state":7,"zip":7,"country":117,"countryCode":118,"cosmosGeoPoint":119,"geoPoint":123,"contacts":7},"Division of Rheumatology & Clinical Immunology, Department of Medicine, Queen Mary Hospital, the University of Hong Kong","ACTIVE_NOT_RECRUITING","Pok Fu Lam","Hong Kong","HK",{"type":32,"coordinates":120},[121,122],114.12924,22.26861,{"lat":122,"lon":121},{"facility":125,"status":25,"city":126,"state":127,"zip":7,"country":128,"countryCode":129,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Padjadjaran University\u002F Hasan Sadikin General Hospital","Bandung","West Java","Indonesia","ID",{"type":32,"coordinates":131},[132,133],107.60694,-6.92222,{"lat":133,"lon":132},[136],{"name":137,"role":15,"phone":7,"phoneExt":7,"email":138},"Laniyati Hamijoyo","hamijoyo@yahoo.com",{"facility":140,"status":25,"city":141,"state":7,"zip":142,"country":143,"countryCode":144,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health","Kitakyushu","807-8555","Japan","JP",{"type":32,"coordinates":146},[147,148],130.85034,33.85181,{"lat":148,"lon":147},[151,154],{"name":152,"role":15,"phone":7,"phoneExt":7,"email":153},"Yoshiya Tanaka","tanaka@med.uoeh-u.ac.jp",{"name":155,"role":66,"phone":7,"phoneExt":7,"email":7},"Yusuke Miyasaki",{"facility":157,"status":25,"city":158,"state":7,"zip":159,"country":143,"countryCode":144,"cosmosGeoPoint":160,"geoPoint":164,"contacts":165},"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University","Tokyo","160-8582",{"type":32,"coordinates":161},[162,163],139.69171,35.6895,{"lat":163,"lon":162},[166],{"name":167,"role":15,"phone":7,"phoneExt":7,"email":168},"Tsutomu Takeuchi","tsutake@z5.keio.jp",{"facility":170,"status":25,"city":158,"state":7,"zip":171,"country":143,"countryCode":144,"cosmosGeoPoint":172,"geoPoint":174,"contacts":175},"Institute of Rheumatology, Tokyo Women's Medical University","162-0054",{"type":32,"coordinates":173},[162,163],{"lat":163,"lon":162},[176,179],{"name":177,"role":15,"phone":7,"phoneExt":7,"email":178},"Masayoshi Harigai","mharigai.mpha@gmail.com",{"name":180,"role":15,"phone":7,"phoneExt":7,"email":181},"Yasuhiro Katsumata","katsumata@ior.twmu.ac.jp",{"facility":183,"status":25,"city":184,"state":7,"zip":185,"country":186,"countryCode":187,"cosmosGeoPoint":188,"geoPoint":192,"contacts":193},"Joint and Bone Center, University of Santo Tomas Hospital","Manila","1008","Philippines","PH",{"type":32,"coordinates":189},[190,191],120.9822,14.6042,{"lat":191,"lon":190},[194],{"name":195,"role":15,"phone":7,"phoneExt":7,"email":196},"Sandra Navarra","sandra_navarra@yahoo.com",{"facility":198,"status":25,"city":199,"state":7,"zip":7,"country":186,"countryCode":187,"cosmosGeoPoint":200,"geoPoint":204,"contacts":205},"University of the Philippines","Quezon City",{"type":32,"coordinates":201},[202,203],121.0509,14.6488,{"lat":203,"lon":202},[206],{"name":207,"role":15,"phone":208,"phoneExt":7,"email":209},"Michael Tee","+63 9 17833 6398","mltee@up.edu.ph",{"facility":211,"status":25,"city":212,"state":7,"zip":213,"country":212,"countryCode":214,"cosmosGeoPoint":215,"geoPoint":219,"contacts":220},"Rheumatology Division, University Medical Cluster, National University Hospital","Singapore","119074","SG",{"type":32,"coordinates":216},[217,218],103.85007,1.28967,{"lat":218,"lon":217},[221],{"name":222,"role":15,"phone":7,"phoneExt":7,"email":223},"Aisha Lateef","Aisha_LATEEF@nuhs.edu.sg",{"facility":225,"status":25,"city":226,"state":7,"zip":227,"country":212,"countryCode":214,"cosmosGeoPoint":7,"geoPoint":7,"contacts":228},"Department of Rheumatology, Allergy & Immunology, Tan Tock Seng Hospital","Tan Tock Seng","308433",[229],{"name":230,"role":15,"phone":7,"phoneExt":7,"email":231},"Madelynn Chan","madelynn_chan@ttsh.com.sg",{"facility":233,"status":25,"city":234,"state":7,"zip":235,"country":236,"countryCode":7,"cosmosGeoPoint":237,"geoPoint":241,"contacts":242},"Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases","Seoul","04763","South Korea",{"type":32,"coordinates":238},[239,240],126.9784,37.566,{"lat":240,"lon":239},[243],{"name":244,"role":15,"phone":7,"phoneExt":7,"email":245},"Sang-Cheol Bae","scbae@hanyang.ac.kr",{"facility":247,"status":25,"city":248,"state":7,"zip":7,"country":249,"countryCode":250,"cosmosGeoPoint":251,"geoPoint":255,"contacts":256},"Division of Nephrology, Teaching Hospital Kandy, Sri Lanka","Kandy","Sri Lanka","LK",{"type":32,"coordinates":252},[253,254],80.6336,7.2906,{"lat":254,"lon":253},[257],{"name":258,"role":15,"phone":259,"phoneExt":7,"email":260},"BMDB Basnayake, MD","+94772252297","bmdbbasnayake@yahoo.com",{"facility":262,"status":25,"city":263,"state":264,"zip":265,"country":266,"countryCode":267,"cosmosGeoPoint":268,"geoPoint":272,"contacts":273},"Department of Rheumatology, Allergy and Immunology Chang Gung Memorial Hospital Chang Gung University","Guishan","Taoyuan County","333","Taiwan","TW",{"type":32,"coordinates":269},[270,271],121.33672,24.99436,{"lat":271,"lon":270},[274,277],{"name":275,"role":15,"phone":7,"phoneExt":7,"email":276},"Shue Fen Luo","lsf00076@adm.cgmh.org.tw",{"name":278,"role":15,"phone":7,"phoneExt":7,"email":279},"Yeong-Jian Wu","yjwu1962@gmail.com",{"facility":281,"status":25,"city":282,"state":7,"zip":283,"country":266,"countryCode":267,"cosmosGeoPoint":284,"geoPoint":288,"contacts":289},"Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital","Taichung","40705",{"type":32,"coordinates":285},[286,287],120.6839,24.1469,{"lat":287,"lon":286},[290],{"name":291,"role":15,"phone":7,"phoneExt":7,"email":292},"Yi-Hsing Chen","dr.yihsing@gmail.com",{"facility":294,"status":25,"city":295,"state":296,"zip":297,"country":298,"countryCode":299,"cosmosGeoPoint":300,"geoPoint":304,"contacts":305},"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University Hospital","Chiang Mai","Muang District","50200","Thailand","TH",{"type":32,"coordinates":301},[302,303],98.98468,18.79038,{"lat":303,"lon":302},[306],{"name":307,"role":15,"phone":7,"phoneExt":7,"email":308},"Worawit Louthrenoo","wlouthre@gmail.com",{"type":310,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[312,315,317,319,321,323,325,327,329,331,333,335,337,339,341,343,345,347,349,351,353,356,358],{"name":313,"class":314},"Flinders Medical Centre, Adelaide, AUSTRALIA","UNKNOWN",{"name":316,"class":314},"St. Vincent's Hospital, Melbourne, AUSTRALIA",{"name":318,"class":6},"Royal Adelaide Hospital",{"name":320,"class":6},"The University of New South Wales",{"name":322,"class":314},"People's Hospital, Peking University Health Science Center, Beijing, CHINA",{"name":324,"class":6},"Peking University First Hospital",{"name":326,"class":6},"The University of Hong Kong",{"name":328,"class":314},"University of Padjadjaran, Bandung, INDONESIA",{"name":330,"class":314},"Tokyo Women's Medical University, JAPAN",{"name":332,"class":314},"University of Occupational and Environmental Health, JAPAN",{"name":334,"class":314},"Keio University, JAPAN",{"name":336,"class":6},"Hanyang University Seoul Hospital",{"name":338,"class":6},"University of Santo Tomas Hospital, Philippines",{"name":340,"class":6},"National University Hospital, Singapore",{"name":342,"class":6},"Tan Tock Seng Hospital",{"name":344,"class":6},"Chang Gung Memorial Hospital",{"name":346,"class":6},"Taichung Veterans General Hospital",{"name":348,"class":314},"Chiang Mai University Hospital, THAILAND",{"name":350,"class":6},"Middlemore Hospital, New Zealand",{"name":352,"class":314},"North Shore Hospital, Auckland, NEW ZEALAND",{"name":354,"class":355},"Auckland District Health Board","OTHER_GOV",{"name":357,"class":314},"Teaching Hospital Kandy, SRI LANKA",{"name":198,"class":6},"100296434","validation-of-the-lupus-low-disease-activity-state-lldas-in-the-asia-pacific-region-100296434",false,"NCT03138941","Validation of the Lupus Low Disease Activity State (LLDAS) in the Asia Pacific Region","APLCLLDAS","Inclusion Criteria:\n\n* All patients have to meet either the 1997 American College of Rheumatology (ACR) Modified Classification Criteria for SLE, with at least four of the 11 items; or alternatively, fulfil the Systemic Lupus International Collaborating Clinics (SLICC) 2012 Classification Criteria, with at least four of the 17 items (at least one clinical and one immunological criterion) or with lupus nephritis in the presence of at least one immunological criteria. Patients can be either newly diagnosed or longstanding lupus patients.\n\nAll patients must be over the age of 18 and competent to provide written consent.\n\nExclusion Criteria:\n\n* Patients less than 18 years of age and patients who are unable to consent are excluded from the study.","ALL","18 Years",{"count":369,"type":370},5000,"ESTIMATED","10 Years","OBSERVATIONAL","Lupus Low Disease Activity State (LLDAS) study is an international, multi-centre prospective study, developed by the Asia Pacific Lupus Collaboration (APLC) to investigate whether the attainment of LLDAS is associated with improved outcomes in patients with Systemic Lupus Erythematosus (SLE).\n\nSLE, or lupus, is the archetypal multisystem autoimmune disease, with an estimated incidence of 5-50 cases per 100,000 people. Patients with SLE, usually young women, suffer a marked loss of life expectancy, and severe morbidity, due to a heterogeneous range of clinical manifestations caused by autoimmune-mediated inflammation of multiple organs. The most severe manifestations of SLE are the accrual of irreversible organ damage, especially renal and central nervous system (CNS) involvement. As there is no effective targeted monotherapy for SLE, patients also suffer severe toxicity from the use of glucocorticoids and broad-spectrum immunosuppressive therapies. Despite combination therapy with current drugs, many studies show that the majority of patients suffer inadequate disease control and inexorably accrue permanent organ damage over time.\n\nThe diversity of clinical features of active SLE has made quantification of disease activity problematic. Although there are a number of published systems in use to measure SLE disease activity, there are widely acknowledged problems with these instruments. Published definitions of remission are so stringent that they are met by less than 5% of patients. This lead to the realisation that rather than lupus remission, a lupus low disease activity state target may be more feasible, and that patients with low disease activity are more homogeneous than patients with active disease. Thus, the development of a definition of lupus low disease activity, which is feasible and has face validity, escapes the complexity of attempts to quantify heterogeneous states of active disease.\n\nIn this study, the investigators will prospectively collect longitudinal data on consecutive SLE patients at each centre to evaluate the LLDAS definition. Protection from organ damage accrual as the primary endpoint.",[375],"Systemic Lupus Erythematosus","2024-12-09",{"date":378,"type":379},"2024-12-12","ACTUAL",{"date":381,"type":379},"2013-09-01",{"date":383,"type":370},"2032-12-31",{"name":5,"class":6},20]