[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637004":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":10,"locations":24,"responsibleParty":44,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":72,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Participants without cognitive impairment",null,"Participanst with a MoCA score greater than or equal to 26\u002F30 and a score greater than the alert threshold based on age and education level on the DTLA scale.\n\nParticipants who have never received a diagnosis of cognitive impairment.",[13],"Diagnostic Test: ExéSem cognitive battery",{"label":15,"type":10,"description":16,"interventionNames":17},"Participants with Cognitive Impairment","Participants receiving memory clinic care with a diagnosis of Alzheimer's disease, at the stage of minor or major neurocognitive impairment, according to the 2011 NIA-AA criteria, or with a diagnosis of vascular neurocognitive impairment according to the VasCog-2-WSO diagnostic criteria , or with a diagnosis of primary progressive aphasia with semantic variant. Participants with a Mini-Mental State Examination (MMSE) score ≥ 20\u002F30, within the 6 months preceding enrollment;",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","ExéSem cognitive battery","The ExéSem battery is a neuropsychological assessment tool designed to evaluate semantic processing and the contribution of executive control in patients with or without neurocognitive disorders. It consists of three tasks: (1) a dual task combining semantic judgment and semantic matching using identical items, (2) a word-to-picture matching task, and (3) a rapid naming task. Each task is structured to manipulate the level of executive demand required to access semantic representations. This variation allows the identification of whether semantic difficulties remain stable or worsen under increased executive load, thereby distinguishing primary semantic deficits from executive-related semantic impairments. The battery is administered by a trained professional using standardized instructions and requires approximately 30 minutes to complete. It is used for diagnostic and research purposes only and does not involve any therapeutic intervention.",[15,9],[25],{"facility":26,"status":10,"city":27,"state":10,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Hopital des CHARPENNES ( Hospices Civils de Lyon)","Lyon","69100","France","FR",{"type":32,"coordinates":33},"Point",[34,35],4.84789,45.74906,{"lat":35,"lon":34},[38],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Floriane DELPHIN-COMBE, MD","CONTACT","472433135","+33","Floriane.delphin-combe@chu-lyon.fr",{"type":45,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100637004","validation-study-of-the-exsem-battery-designed-to-differentiate-the-contribution-of-executive-functions-in-semantic-disorders-100637004",false,"NCT07573046","Validation Study of the ExéSem Battery Designed to Differentiate the Contribution of Executive Functions in Semantic Disorders","ExéSemVal","Inclusion Criteria:\n\n* \\- Participants without cognitive impairment\n* Participant aged 50 to 90 years (inclusive);\n* Participant whose native language is French\n* Participant affiliated with or entitled to a social security scheme;\n* Participants who have been informed and have not objected.\n* Participants with cognitive impairment\n* Participant aged 50 to 90 years (inclusive);\n* Participant whose native language is French\n* Participant receiving memory care with a diagnosis of Alzheimer's disease, at the stage of minor or major neurocognitive impairment, according to the 2011 NIA-AA criteria (McKahn et al., 2011), or with a diagnosis of vascular neurocognitive impairment according to the VasCog-2-WSO diagnostic criteria (Sachdev et al., 2025), or with a diagnosis of primary progressive aphasia with semantic variant (Gorno-Tempini et al., 2011).\n* Mini-Mental State Examination (MMSE) score ≥ 20\u002F30, within the 6 months preceding enrollment;\n* Participants affiliated with or entitled to a social security scheme;\n* Participants who have been informed and have not objected.\n\nExclusion Criteria:\n\n* \\- For all participants:\n* Severe, progressive, or unstable medical conditions that may interfere with assessment variables (epilepsy, acute psychiatric or psychotic disorders, visual hallucinations, acute infection);\n* Substance use that may affect cognitive performance;\n* Deafness or blindness that may compromise the participant's assessment or participation in tasks and scales;\n* Participants under guardianship, curatorship, or legal protection;\n* Pregnant, postpartum, or breastfeeding women.\n* Specifically for participants without cognitive impairment:\n* Participants previously diagnosed with cognitive impairment.\n* Specifically for participants with cognitive impairment:\n* Severe behavioral and psychological symptoms that prevent task completion, as determined by the investigator.",true,"ALL","50 Years","90 Years",{"count":58,"type":59},140,"ESTIMATED","OBSERVATIONAL","This protocol describes a study aimed at evaluating the psychometric properties of the ExéSem battery, developed to differentiate semantic deficits from executive semantic impairments in patients with post-lesional or neurodegenerative anomia. Currently available tools do not allow a straightforward distinction between these deficits, limiting diagnostic accuracy and clinical management. The ExéSem battery was developed through a collaboration between Hospices Civils de Lyon, the University of Mons, and Laval University to address this gap.\n\nThe battery includes three main tasks: (1) a dual task combining semantic judgment and semantic matching using identical items, (2) a word-picture matching task, and (3) a rapid naming task. Each task is designed to manipulate the level of executive control required to access semantic representations. This allows the identification of whether performance declines under increased executive demand, thereby distinguishing executive-related semantic impairments.",[63,64,65,66],"Alzheimer's Disease","Vascular Neurocognitive Disorder","Progressive Primary Aphasia Semantic Variant","People Without Neurocognitive Disorder",[68,69,70,71],"Anomia","Semantic disorders","Executive control","Neurocognitive disorders","NOT_YET_RECRUITING","2026-05-04",{"date":75,"type":76},"2026-05-07","ACTUAL",{"date":78,"type":59},"2026-09-09",{"date":80,"type":59},"2029-09-09",{"name":5,"class":6},1]