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Diagnosis must be made no more than 3 months (90 days) prior to inclusion. Diagnosis of chronic-phase CML (European Leukemia Network \\[ELN\\] 2020 criteria; Baccarani et al 2013) with confirmation of a Philadelphia chromosome (Ph1). A cryptic Ph1 chromosome must be confirmed by FISH.Criteria must meet the definition of chronic phase CML\n* BCR ::ABL1 transcript quantifiable by quantitative PCR\n* 1st-line treatment with tyrosine kinase inhibitor\n* No tyrosine kinase inhibitor or hydroxyurea treatment received prior to first blood sampling (at diagnosis)\n* Signature of informed consent for CML Observatory and signature of informed consent for BIO-TIMER protocol\n* Read and understand French\n* Enrolled in a social security plan or beneficiary of such a plan\n\nExclusion Criteria:\n\n* CML in accelerated or blast phase\n* Refusal to participate in the study\n* Treatment started prior to inclusion\n* Patients under guardianship, curatorship, deprivation of liberty or safeguard of justice\n* Pregnant or breast-feeding women","ALL","18 Years",{"count":259,"type":260},321,"ESTIMATED","INTERVENTIONAL",[263],"NA","French prospective multicenter, open-label study involving newly diagnosed CML patients. Two assessments will be performed during the follow-up of these patients: individual frailty using geriatric tools and individual biological aging determined by DNA methylation analysis.",[266],"Leukemia,Myeloid, Chronic","2024-09-26",{"date":269,"type":270},"2024-09-27","ACTUAL",{"date":272,"type":270},"2023-11-17",{"date":274,"type":260},"2028-11-17",{"name":5,"class":6},17]