[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100505700":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":30,"responsibleParty":73,"collaborators":20,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":20,"enrollmentInfo":85,"targetDuration":20,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":32,"whyStopped":20,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University Medical Center Groningen","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Screening population","EXPERIMENTAL","Patients with newly diagnosed stage IV non-oncogene addicted NSCLC, who are fit for systemic treatment and don't have any symptoms of brain disease.",[13],"Diagnostic Test: MRI",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIAGNOSTIC_TEST","MRI","MRI scan of the brain",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"F. Bensch, MD, PhD","CONTACT","0031503616161","f.bensch@umcg.nl",{"name":28,"role":24,"phone":25,"phoneExt":20,"email":29},"L.B.M. Hijmering, MD","l.b.m.hijmering-kappelle@umcg.nl",[31,47,60],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Groningen","Provincie Groningen","9713LZ","Netherlands","NL",{"type":39,"coordinates":40},"Point",[41,42],6.56667,53.21917,{"lat":42,"lon":41},[45],{"name":46,"role":24,"phone":20,"phoneExt":20,"email":20},"Frederike Bensch, MD, PhD",{"facility":48,"status":32,"city":49,"state":20,"zip":20,"country":36,"countryCode":37,"cosmosGeoPoint":50,"geoPoint":54,"contacts":55},"Maastricht UMC+","Maastricht",{"type":39,"coordinates":51},[52,53],5.68889,50.84833,{"lat":53,"lon":52},[56],{"name":57,"role":24,"phone":20,"phoneExt":58,"email":59},"Lizza Hendriks","+314338750","lizza.hendriks@mumc.nl",{"facility":61,"status":32,"city":62,"state":20,"zip":20,"country":36,"countryCode":37,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Ommelander Ziekenhuisgroep","Scheemda",{"type":39,"coordinates":64},[65,66],6.97222,53.17333,{"lat":66,"lon":65},[69],{"name":70,"role":24,"phone":71,"phoneExt":20,"email":72},"Alice Staats","031652724738","a.niemeijer@ozg.nl",{"type":74,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100505700","value-of-screening-mri-brain-in-stage-iv-non-small-cell-lung-cancer-100505700",false,"NCT05864794","Value of Screening MRI Brain in Stage IV Non-small Cell Lung Cancer","ValUe of Screening MRI Brain in Patients With Newly Diagnosed Stage IV Non-oncogene Addicted Non-small Cell Lung CANcer - The VULCAN Trial","VULCAN","Inclusion Criteria:\n\n* Histologically or cytologically confirmed stage IV metastatic NSCLC, not amenable to curative treatment.\n* Fit for systemic treatment (PS 0-2) according to standard of care.\n* No symptoms of brain disease disease assessed according to standard clinical care by the thoracic oncologist.\n\nExclusion Criteria:\n\n* Prior\u002Fconcomitant therapy for stage IV disease.\n* Oncogenic diver mutation (e.g. EGFR, ALK, ROS1, RET, MET, and BRAF) with approved targeted treatment.\n* Contraindications for MRI scan with contrast as per standard of care protocol of the institution.","ALL","18 Years",{"count":86,"type":87},100,"ESTIMATED","INTERVENTIONAL",[90],"NA","Patients with newly diagnosed stage IV non-oncogene addicted NSCLC, who are fit for systemic treatment and don't have any symptoms of brain disease will undergo an MRI of the brain to screen for brain disease.",[93],"Non Small Cell Lung Cancer Metastatic",[95,96],"brain metastasis","screening","2026-06-08",{"date":99,"type":100},"2026-06-09","ACTUAL",{"date":102,"type":100},"2024-05-13",{"date":104,"type":87},"2028-12-31",{"name":5,"class":6},3]