[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640104":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":39,"responsibleParty":45,"collaborators":48,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":39,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":74,"overallStatus":76,"whyStopped":39,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":39},{"fullName":5,"class":6},"Indiana University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High-intensity training in variable contexts","EXPERIMENTAL","High-intensity training focused on stepping tasks in variable contexts (tasks and environments) while targeting higher cardiovascular intensity (\\>75% maximum predicted heart rates) during up to 40 mins of 1-hr sessions. A total of 20 sessions will be targeted.",[13],"Other: High-intensity training in variable contexts",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional balance training","ACTIVE_COMPARATOR","Conventional balance activities will consist of sitting and standing balance exercises, with selected dynamic stability exercises performed during walking tasks. Heart rates will be monitored with no targeted range. All sessions will be 1-hr long with balance activities for up to 40 minutes per session. A total of 20 sessions will be targeted.",[19],"Other: Conventional balance training",[21,26],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"High intensity stepping training: Training sessions will focus on maximizing stepping activities in variable contexts while targeting ≥70% HR reserve (or approximately 80% age-predicted maximum HR) calculated using the Karvonen formula. Target HR will be decreased by 10 beats if the individual is on beta-blockers. Intensity will also be monitored using the Borg RPE scale every 3-5 minutes with goals of ≥15 on a 6-20 scale. The intensity of the walking training will be primarily modulated through the treadmill speed and incline as well as addition of weights to the torso or limbs for the purpose of error augmentation and not to dampen ataxia. Sessions will focus on achieving up to 40 minutes of stepping training within each 60-minute session. Potential tasks include walking in multiple directions, over inclines and obstacles, and\u002For with weighted vests and leg weights with limited handrail use as tolerated and decided by the therapist and participant.",[9],[25],"Locomotor training at higher intensities",{"type":6,"name":15,"description":27,"armGroupLabels":28,"otherNames":29},"Conventional training: Training sessions will focus on improving static and dynamic balance, while calculated using the Karvonen formula. Target HR ranges will be decreased by 10 beats if the individual is on beta-blockers. Intensity will also be monitored using heart rates and RPE every 3-5 minutes with goals of \\\u003C14 on a 6-20 scale. Sessions will focus on balance training for up to 40 minutes within a 60-minute session. Individuals will perform \\~10 minutes (\\~25% of sessions) on balance activities in the sitting position, \\~20 minutes (50% of sessions) of standing positions and \\~10 minutes (25% of sessions) of walking training.",[15],[30],"Static and dynamic stability training",[32],{"name":33,"affiliation":5,"role":34},"Thomas G Hornby","PRINCIPAL_INVESTIGATOR",[36,41],{"name":33,"role":37,"phone":38,"phoneExt":39,"email":40},"CONTACT","3123508291",null,"tghornby@iu.edu",{"name":42,"role":37,"phone":43,"phoneExt":39,"email":44},"Christopher Henderson","3173292353","henderce@iu.edu",{"type":34,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":39,"oldOrganization":39},"George Hornby","Professor",[49],{"name":50,"class":6},"Rehabilitation Hospital of Indiana","100640104","variable-intense-training-for-ataxia-and-locomotion-100640104",false,"NCT07621978","Variable Intense Training for Ataxia and Locomotion","Feasibility and Potential Efficacy of High-intensity Gait Training in Individuals With Cerebellar Damage","VITAL","Inclusion Criteria:\n\n* Ages 18-85\n* \\>6 months following brain injury or diagnosis of cerebellar dysfunction\n* A total score of \\> 4 on items 5-8 on the SARA for the ipsilateral limb\n* Ability to ambulate 10 m at self-selected gait speeds (SSV) \\\u003C1.2 m\u002Fs with no greater than minimal physical assistance permitted for postural stability only, but with below knee bracing and\u002For assistive device as needed\n* Weight \\\u003C 350 pounds\n* Able to follow 1-step command\n* Medical clearance to participate\n\nExclusion Criteria:\n\n* Uncontrolled cardiopulmonary or metabolic disease that limits exercise participation, active heterotopic ossification, recurrent history of lower extremity fractures, previous orthopedic or other peripheral or central neurologic injury that may impair locomotor activities\n* Currently participating in other physical therapy\n* \\>50 units of Botox within the past three months in the lower extremity OR in the lower extremity, but above the knee if the participant wears an ankle-foot-orthosis\n* Individuals deemed not stable between Pre-Baseline Testing and Baseline Testing","ALL","18 Years","85 Years",{"count":63,"type":64},20,"ESTIMATED","INTERVENTIONAL",[67],"NA","The goal of this study is to evaluate the feasibility and potential preliminary efficiency of high-intensity training focused on stepping in variable contexts as compared to conventional training in individuals with cerebellar disease",[70,71,72,73],"Cerebellar Disorders","Cerebellar Degeneration","Cerebellar Atrophy","Cerebellar Lesions",[75],"Cerebellar diseases, high-intensity training","NOT_YET_RECRUITING","2026-05-27",{"date":79,"type":80},"2026-06-02","ACTUAL",{"date":82,"type":64},"2026-06-15",{"date":84,"type":64},"2028-12-15",{"name":5,"class":6}]