[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558685":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":30,"locations":39,"responsibleParty":54,"collaborators":57,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":18,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":18,"enrollmentInfo":71,"targetDuration":18,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":42,"whyStopped":18,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Massachusetts, Boston","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Home-based aerobic training","EXPERIMENTAL","A 3-month home-based exercise training intervention comprising cycle ergometry as an aerobic mode of training coupled with behavioral coaching. The regimen will be delivered 3-4 days per week.",[13],"Behavioral: Home-based aerobic training",{"label":15,"type":16,"description":17,"interventionNames":18},"Attention control","NO_INTERVENTION","The alternative treatment condition comprises a stretching program with minimal exercise and attention control. This program will be delivered using the same frequency and duration as the intervention. The first session will be conducted under the supervision of visiting study personnel as described above. The stretching exercises will follow the manual provided by the National Multiple Sclerosis Society and the investigators will progressively include more exercises and sets over the 3 months, this too has been standardized and manualized for reproducibility. The investigators will provide the same materials and Internet coaching for the attention control group as for the intervention group but focused on stretching and not on increasing aerobic exercise. The investigators will ask that participants not undertake additional exercise during the study duration and this will be documented through an exercise history, the Godin Leisure-Time Exercise Questionnaire.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"BEHAVIORAL","The aerobic training will focus on large, dynamic movements of the lower extremities using leg cycling ergometry on an upright cycle ergometer installed in the participant's homes and will progress in duration (10-40 minutes) and intensity (50-70% VO2 peak) over the 3-month intervention period. All participants will start exercise at 50% of VO2peak for 10-min as determined by the exercise test, for the first week, to individualize the exercise prescription. Progression will initially target duration with weekly progressions of 5 min to 30 min of exercise, followed by progression of intensity by 5% per week until 70% is attained, based on patient tolerance of the increased work.",[9],[25,28],{"name":26,"affiliation":5,"role":27},"Bo Fernhall, PhD","PRINCIPAL_INVESTIGATOR",{"name":29,"affiliation":5,"role":27},"Tracy Baynard, PhD",[31,35],{"name":29,"role":32,"phone":33,"phoneExt":18,"email":34},"CONTACT","2178404493","tracy.baynard@umb.edu",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},"Joao L Maroco, MS","7738933897","joao.maroco001@umb.edu",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":18},"UMass Boston","RECRUITING","Boston","Massachusetts","02125","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-71.05977,42.35843,{"lat":52,"lon":51},{"type":27,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Tracy Baynard","Professor and Assoc Vice Provost, Grad Edu",[58,60],{"name":59,"class":6},"University of Illinois at Chicago",{"name":61,"class":6},"University of Alabama at Birmingham","100558685","vascular-mechanisms-functional-outcomes--exercise-among-persons-with-multiple-sclerosis-with-hypertension-100558685",false,"NCT06554340","Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension","Targeting Vascular Mechanisms of Functional Outcomes Via Home-based Exercise Training Among Persons With Multiple Sclerosis Who Have Hypertension","Inclusion Criteria:\n\n* Persons with confirmed multiple sclerosis diagnosis with Expanded Disability Status Scale scores of 4-6.5, characteristic of 2nd stage of multiple sclerosis;\n* Hypertension defined as elevated, or Stage 1 or 2, as per the 2017 American Heart Association guidelines (brachial systolic blood pressure \\> 120 mmHg or brachial diastolic blood pressure \\> 80 mmHg)\n* Persons who are physically inactive (less than 60 min\u002Fwk of physical activity);\n* Persons with body mass index \\\u003C 40 kg\u002Fm2;\n* Persons who are not confined to a wheel chair;\n* Multiple sclerosis relapse in the past 30 days;\n* People with stable pharmacotherapy.\n\nExclusion Criteria:\n\n* People with additional cardiovascular comorbidities;\n* People with type 1 diabetes mellitus;\n* Physician disapproval to participating in the study;\n* Space constraints to fit a cycle ergometer at the home of prospective participants.","ALL","18 Years",{"count":72,"type":73},80,"ESTIMATED","INTERVENTIONAL",[76],"NA","The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multiple sclerosis who have high blood pressure, when compared to a group that engages in a 12-week home-based stretching program.\n\nThe main questions this study aims to answer are:\n\n1. Can home-based cycling exercise training improve blood pressure by increasing blood vessel dilation in people with multiple sclerosis?\n2. Can cycling exercise training improve cognition and walking mobility in people with multiple sclerosis by improving blood pressure?\n\nThe investigators will compare home-based cycling training to stretching to see if cycling training improves cognition, walking mobility, blood pressure, and fitness in people with multiple sclerosis.\n\nParticipation in this study will take 13-14 weeks, with participants being randomized (like flipping a coin, a 50-50 chance of being in either group) to the home-based cycling training or the stretching group.\n\nAll participants will be asked to\n\n* Visit the laboratory two times, one before the beginning of the intervention (home-base training and stretching group) and one at the end of the intervention.\n* During visits, participants will complete tests related to cognition, walking mobility, blood pressure and fitness.",[79,80],"Multiple Sclerosis","Hypertension",[82,83,84,85],"exercise","blood pressure","mobility","cognition","2025-08-15",{"date":88,"type":89},"2025-08-22","ACTUAL",{"date":91,"type":89},"2025-04-15",{"date":93,"type":73},"2027-08",{"name":5,"class":6},1]