[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616533":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":24,"locations":18,"responsibleParty":30,"collaborators":18,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":37,"acronym":18,"eligibilityCriteria":38,"healthyVolunteers":35,"sex":39,"minAge":40,"maxAge":18,"enrollmentInfo":41,"targetDuration":18,"studyType":44,"phases":45,"briefSummary":47,"conditions":48,"keywords":51,"overallStatus":55,"whyStopped":18,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":18},{"fullName":5,"class":6},"Alexandria University","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Predictors of Postoperative outcome in Whipple Procedures","Patients undergoing Whipple surgery monitored for CO₂-derived perfusion markers (Pv-aCO₂\u002FCa-vO₂ ratio) \\& Lactate as a traditional perfusion markers.",[12],"Other: predictors of postoperative outcome in Whipple Procedures",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":18},"predictors of postoperative outcome in Whipple Procedures","CO₂-Derived Parameters \\& Lactate as Predictors of Postoperative outcome in Whipple Procedures and the occurrence of complications",[9],null,[20],{"name":21,"affiliation":22,"role":23},"Alaa Anwar Abdelrahman, Dr","University of Alexandria","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Alaa Anwar Abdelrahman, MD","CONTACT","00201281218573","A_Aly16@alexmed.edu.eg",{"type":23,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Alaa Anwar Aly Ahmed","LECTURER OF ANESTHESIA AND SURGICAL INTENSIVE CARE","100616533","veno-arterial-co2-pressure-difference-to-arterio-venous-o2-difference-ratio--blood-lactate-levels-are-predictors-of-postoperative-outcome-in-whipple-procedures-100616533",false,"NCT07306845","Veno-arterial CO2 Pressure Difference to Arterio-venous O2 Difference Ratio & Blood Lactate Levels Are Predictors of Postoperative Outcome in Whipple Procedures","Inclusion Criteria:\n\n* Adults (\\>18 years) undergoing open Whipple procedure under general anesthesia\n* Invasive monitoring (arterial line and central venous catheter)\n* Informed written consent\n\nExclusion Criteria:\n\n* Emergency surgery.\n* Preoperative septic shock or hemodynamic instability.\n* severe pre-existing \\*\\*cardiopulmonary disease (e.g., severe COPD, heart failure).","ALL","18 Years",{"count":42,"type":43},120,"ESTIMATED","INTERVENTIONAL",[46],"NA","Whipple surgery is a complex abdominal procedure associated with a high risk of hemodynamic instability and splanchnic hypoperfusion leading to anastomotic leaks, delayed gastric emptying, and organ dysfunction Traditional markers (e.g., MAP, mixed venous oxygen saturation \\[SvO₂\\], lactate) are indirect, invasive and often delayed.\n\nCO₂-derived variables (e.g., venous-to-arterial CO₂ gap \\[ΔCO₂\\], tissue CO₂ \\[PtCO₂\\], end-tidal CO₂ \\[EtCO₂\\] changes) provide earlier and more sensitive signs of microcirculatory dysfunction.",[49,50],"Postoperative Outcome","Whipple Procedures",[52,53,54],"CO2 Pressure Difference","O2 Difference","Blood Lactate","NOT_YET_RECRUITING","2025-12-13",{"date":58,"type":59},"2025-12-29","ACTUAL",{"date":61,"type":43},"2025-12-25",{"date":63,"type":43},"2026-06-25",{"name":5,"class":6}]