[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609872":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":25,"responsibleParty":42,"collaborators":25,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":25,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":25,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":72,"whyStopped":25,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":25},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Fontan circulation Arm","EXPERIMENTAL","Fontan circulation participants will undergo Rest +Submax exercise with and without wearing venous compression garments.\n\nA subset of patients with Fontan circulation will undergo repeat testing 2-weeks later.",[13,14],"Device: Lower extremity compression garments","Other: Without compression garments",{"label":16,"type":10,"description":17,"interventionNames":18},"Healthy controls","Healthy group participants will undergo Rest +Submax exercise with and without wearing venous compression garments.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Lower extremity compression garments","Acute and 2-week effects of compression garments",[9,16],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Without compression garments","Acute effects without compression garments",[9,16],[31],{"name":32,"affiliation":5,"role":33},"Keri Shafer, MD","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","2146451165","keri.shafer@utsouthwestern.edu",{"name":40,"role":36,"phone":37,"phoneExt":25,"email":41},"Denis J Wakeham, PhD","denis.wakeham@utsouthwestern.edu",{"type":33,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Keri Shafer","Associate Professor of Medicine","100609872","venous-compression-in-fontan-100609872",false,"NCT07220226","Venous Compression in Fontan","Venous Function and the Effect of Venous Compression on Exercise Cardiovascular Function in Patients With Fontan Circulation.","Patients with a Fontan circulation -\n\nInclusion criteria:\n\n• Patients at UTSW aged 18-45 years old with a Fontan circulation.\n\nExclusion Criteria:\n\n* NYHA Class 4\n* Severe AV valve regurgitation\n* Severe ventricular dysfunction\n* Large ascites\n* Significant varicosities\n* Atrio-pulmonary (AP) Fontan\n* Known Fontan thrombus\n* Poorly controlled arrythmia\n* Unplanned cardiac admission in the last 6 months\n* Cyanosis (resting O2 saturation \\\u003C85%)\n* Pregnant\n* Common femoral vein obstruction \\>50% to be performed following completion of informed consent.\n\nHealthy Controls:\n\nHealthy control participants will be recruited on the basis of having no known chronic diseases and not currently taking any cardiovascular medications.",true,"ALL","18 Years","45 Years",{"count":57,"type":58},20,"ESTIMATED","INTERVENTIONAL",[61],"NA","The aim of this study is to investigate whether venous compression garments increase exercise stroke volume in patients with Fontan circulation. To address this aim, we will test the following hypotheses:\n\n1. Acute and chronic external venous compression will increase exercise stroke volume in patients with Fontan circulation.\n2. Patients with significant venous varicosities will have a greater response to venous compression.\n\nParticipants will:\n\n* Undergo submaximal exercise testing in MRI to measure venous return and exercise stroke volume with and without the wearing of compression garments\n* Undergo submaximal exercise testing on a seated upright exercise ergometer with concurrent measurement of stroke volume with and without the wearing of compression garments\n* A subset of participants will repeat both testing visits after wearing compression garments for 2-weeks during waking hours.\n\nParticipants will:\n\n* Undergo submaximal exercise testing in MRI to measure venous return and exercise stroke volume with and without the wearing of compression garments\n* Undergo submaximal exercise testing on a seated upright exercise ergometer with concurrent measurement of stroke volume with and without the wearing of compression garments\n* A subset of participants will repeat both testing visits after wearing compression garments for 2-weeks during waking hours.",[64,65],"Single-ventricle","Fontan Circulation",[67,68,69,65,70,71],"Venous Compression","Exercise Testing","Cardiac Reserve","Magnetic Resonance Imaging","vascular function","NOT_YET_RECRUITING","2026-04-18",{"date":75,"type":76},"2026-04-22","ACTUAL",{"date":78,"type":58},"2026-05-10",{"date":80,"type":58},"2027-11-01",{"name":5,"class":6}]