[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629533":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":30,"collaborators":10,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":40,"eligibilityCriteria":41,"healthyVolunteers":36,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":10,"studyType":48,"phases":10,"briefSummary":49,"conditions":50,"keywords":55,"overallStatus":61,"whyStopped":10,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Major Limb Trauma Cohort",null,"Adult patients with major upper or lower limb trauma requiring surgical treatment and\u002For prolonged immobilization (≥72 hours). Participants will be enrolled within 72 hours of admission and followed prospectively for 6 months to evaluate the association between venous thromboembolism (VTE) and persistent post-traumatic pain. VTE events will be identified during hospitalization or within 30 days after injury using standard diagnostic imaging.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Dmytro Dmitriy Dmytriiev, PhD.Professor","CONTACT","+380674309449","d.dmytriiev@superhumans.com",[19],{"facility":20,"status":10,"city":21,"state":10,"zip":10,"country":22,"countryCode":23,"cosmosGeoPoint":24,"geoPoint":29,"contacts":10},"Superhumans War Trauma Center","Lviv","Ukraine","UA",{"type":25,"coordinates":26},"Point",[27,28],24.02324,49.83826,{"lat":28,"lon":27},{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dmytro Dmytriiev","Chief of science department, PhD, Professor","100629533","venous-thromboembolism-and-chronic-pain-after-major-limb-trauma-100629533",false,"NCT07475910","Venous Thromboembolism and Chronic Pain After Major Limb Trauma","Venous Thromboembolism and Chronic Pain After Major Limb Trauma: A Prospective Cohort Study","THROMBO-PAIN","Inclusion Criteria:\n\n* Age ≥18 years\n* Major upper or lower limb trauma\n* Surgical treatment and\u002For immobilization ≥72 hours\n* Enrollment within 72 hours of admission\n* Informed consent\n\nExclusion Criteria:\n\n* Pre-existing chronic pain unrelated to trauma (investigator judgment)\n* Therapeutic anticoagulation prior to trauma\n* Cognitive inability to complete follow-up\n* Expected survival \\\u003C48 hours","ALL","18 Years","60 Years",{"count":46,"type":47},150,"ESTIMATED","OBSERVATIONAL","Major limb trauma is associated with a high risk of venous thromboembolism (VTE) due to systemic inflammation, endothelial injury, immobilization, and hypercoagulability. While VTE is commonly studied as a short-term complication affecting morbidity and mortality, its potential relationship with long-term pain outcomes after trauma has not been well investigated.\n\nThis prospective observational cohort study aims to evaluate whether objectively confirmed VTE is associated with an increased risk of persistent clinically significant pain after major limb trauma. Adult patients with severe upper or lower limb injuries requiring surgical treatment or prolonged immobilization will be enrolled within 72 hours of hospital admission and followed for six months.\n\nThe study will assess whether patients who develop VTE have a higher likelihood of persistent pain compared with those without VTE. In addition, the study will explore the association between baseline VTE risk (using the Trauma Embolic Scoring System, TESS), thromboprophylaxis timing, and long-term pain outcomes. Secondary analyses will evaluate neuropathic pain symptoms, pain interference with daily activities, quality of life, opioid consumption, and functional recovery.\n\nUnderstanding the relationship between thromboembolic complications and persistent pain may help improve risk stratification, optimize thromboprophylaxis strategies, and support early rehabilitation planning in patients with major limb trauma.",[51,52,53,54],"VTE (Venous Thromboembolism)","Phantom Limb Pain After Amputation","Chronic Pain","Chronic Pain Due to Injury",[56,57,58,59,60],"Venous thromboembolism","Post-traumatic chronic pain","Neuropathic pain","Major limb trauma","Trauma Embolic Scoring System (TESS)","NOT_YET_RECRUITING","2026-03-16",{"date":64,"type":65},"2026-03-18","ACTUAL",{"date":67,"type":47},"2026-03-15",{"date":67,"type":47},{"name":5,"class":6},1]