[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620145":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":34,"centralContacts":42,"locations":52,"responsibleParty":60,"collaborators":29,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":29,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":29,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":29,"overallStatus":83,"whyStopped":29,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Conventional Chest Physiotherapy","PLACEBO_COMPARATOR","twenty mechanically ventilated patients with acute respiratory failure, who will receive the routine plan of weaning and conventional chest physiotherapy from MV twice a day with a 4-6 hour gap between for 4-5 days a week till extubation.",[13],"Other: routine plan of weaning and Conventional Chest Physiotherapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Trigger Sensitivity IMT","EXPERIMENTAL","twenty mechanically ventilated patients with acute respiratory failure, who will receive inspiratory muscle training by gradual inspiratory flow trigger sensitivity optimization in addition to the routine plan of weaning and conventional chest physiotherapy from MV, twice a day with a 4-6 hour gap between, for 4-5 days a week till extubation.",[19,13],"Other: adjustment of parameters on mechanical ventilation device",{"label":21,"type":16,"description":22,"interventionNames":23},"Stepwise Pressure Support Reduction IMT","twenty mechanically ventilated patients with acute respiratory failure, who will receive inspiratory muscle training via stepwise pressure support reduction in addition to the routine plan of weaning and conventional chest physiotherapy from MV, twice a day with a 4-6 hour gap between, for 4-5 days a week till extubation.",[19,13],[25,30],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"adjustment of parameters on mechanical ventilation device","adjust the parameters of the mode of training on mechanical ventilation according the group of patients",[21,15],null,{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":29},"routine plan of weaning and Conventional Chest Physiotherapy","Chest Physiotherapy including: ▪ Postural Drainage ▪ Manual techniques for airway clearance (percussion, vibration, shaking) Adding to range of passive to active movements of the limbs",[9,21,15],[35,39],{"name":36,"affiliation":37,"role":38},"Mahmoud E Ragab, M.Sc.","Kasr Al Ainy hospital, Cairo University","PRINCIPAL_INVESTIGATOR",{"name":40,"affiliation":5,"role":41},"Nesreen G' EL-NAHAS, PhD","STUDY_CHAIR",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":29,"email":47},"Mahmoud E Ragab, MSc","CONTACT","+201001218587","mr.syndrome.264@gmail.com",{"name":49,"role":45,"phone":50,"phoneExt":29,"email":51},"SHYMAA T Mohamed, PhD","+201021088610","Shimaa.taha395@gmail.com",[53],{"facility":54,"status":29,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":29,"geoPoint":29,"contacts":29},"kasr Al Ainy Hospital","Cairo","Giza Governorate","11956","Egypt","EG",{"type":38,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Mahmoud El-Sayed Abduh Ragab","Assistant Lecturer Dr.","100620145","ventilator-based-inspiratory-muscle-training-for-patients-with-respiratory-failure-100620145",false,"NCT07353814","Ventilator-based Inspiratory Muscle Training for Patients With Respiratory Failure","Ventilator-based Inspiratory Muscle Training: Trigger Sensitivity Adjustment Versus Stepwise Pressure Support Reduction for Patients With Respiratory Failure","Inclusion Criteria:\n\n* Acute respiratory failure patients in the ICU are receiving MV for 48 h or more in a controlled mode.\n* Their ages will range from 40 to 55 years old, and both sexes will be included.\n* Conscious and oriented patients with a Glasgow coma score ≥13 (≥9T).\n* Alertness score with a Richmond Agitation-Sedation Scale (RASS) will be from 0 to -1.\n* All patients in this study must be hemodynamically and medically stable.\n* Patients must be able to trigger spontaneous breaths on the ventilator but couldn't generate maximum inspiratory pressure more than -15 mbar.\n\nExclusion Criteria:\n\n* Persistent hemodynamic instability as life-threatening conditions or comorbidities interfere with and compromise weaning, like cardiac arrhythmia, pericardial effusion, congestive heart failure, or acute coronary syndrome.\n* Severe breathlessness when spontaneously breathing.\n* Any progressive neuromuscular disease, such as myopathy or neuropathy, that would interfere with responding to inspiratory muscle training due to inadequate training performance of the inspiratory muscle.\n* Spinal cord injury.\n* Skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs.\n* Patients in a coma or under heavy sedation (RASS ≤ -2) and with respiratory muscle paralysis.\n* High peak airway pressure (barotrauma), high PEEP \\>10, or active pneumothorax.","ALL","40 Years","55 Years",{"count":74,"type":75},60,"ESTIMATED","INTERVENTIONAL",[78],"NA","This study will be conducted to compare the effectiveness of progressive inspiratory flow trigger sensitivity rising versus stepwise pressure support reduction as ventilator-based inspiratory muscle training methods on weaning and extubation success in mechanically ventilated patients with respiratory failure.",[81,82],"Respiratory Failure","Mechanical Ventilation Complication","NOT_YET_RECRUITING","2026-01-17",{"date":86,"type":87},"2026-01-20","ACTUAL",{"date":89,"type":75},"2026-01",{"date":91,"type":75},"2027-03",{"name":5,"class":6},1]