[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100528935":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":28,"centralContacts":32,"locations":37,"responsibleParty":53,"collaborators":22,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":22,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":22,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":22,"overallStatus":40,"whyStopped":22,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Threshold inspiratory muscle trainer","EXPERIMENTAL","Training of the inspiratory muscles by threshold inspiratory muscle trainer.",[13],"Other: Threshold inspiratory muscle trainer or ventilator pressure setting inspiratory muscle training techniques",{"label":15,"type":10,"description":16,"interventionNames":17},"Ventilator pressure setting inspiratory muscle training","Training of the inspiratory muscles by ventilator pressure setting.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Traditional treatment","NO_INTERVENTION","Only prescribed medical treatment programme",null,[24],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":22},"Threshold inspiratory muscle trainer or ventilator pressure setting inspiratory muscle training techniques","New techniques to train inspiratory muscles in mechanically ventilated patients",[9,15],[29],{"name":30,"affiliation":5,"role":31},"Elmasry","STUDY_DIRECTOR",[33],{"name":30,"role":34,"phone":35,"phoneExt":22,"email":36},"CONTACT","01005587119","egydodo@rocketmail.com",[38],{"facility":39,"status":40,"city":41,"state":22,"zip":22,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Kasr Al Ainy School of Medicine","RECRUITING","Cairo","Egypt","EG",{"type":45,"coordinates":46},"Point",[47,48],31.24967,30.06263,{"lat":48,"lon":47},[51],{"name":52,"role":34,"phone":22,"phoneExt":22,"email":22},"School of Medicine",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","El-Sayed Essam","Lecturer at Department of Physical Therapy for Cardiovascular\u002FRespiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University","100528935","ventilator-trigger-sensitivity-adjustment-versus-threshold-inspiratory-muscle-training-on-arterial-blood-gases-100528935",false,"NCT06167239","Ventilator Trigger Sensitivity Adjustment Versus Threshold Inspiratory Muscle Training on Arterial Blood Gases","Effect of Ventilator Trigger Sensitivity Adjustment Versus Threshold Inspiratory Muscle Training on Arterial Blood Gases in Mechanically Ventilated Patients, a Randomized Clinical Trail","Inclusion Criteria:\n\n1. Difficult to wean Guillain barre patients who have been on MV for at least 48 hours. Difficult to wean subjects have been defined as those who fail the first spontaneous breathing trial (SBT)and may require up to 3 SBTs or up to 7 d from the first attempt to achieve successful weaning (B´eduneau G. et al.,2017) and (Annia F. et al.,2019).\n2. Age: \\>18 years.\n3. Both sexes will be included.\n4. Ventilator mode: Pressure support mode with FiO2≤ 0.5, positive end expiratory pressure (PEEP) will be\\\u003C8-10cm\u002FH2Oand respiratory rate \\\u003C 25.\n5. Conscious oriented patient with Glasgow coma score ≥13.\n6. Alertness will be titrated to a Riker Sedation Agitation Score of 4.\n7. PH\\>7.25, arterial oxygen saturation \\>90%.\n8. Cardiovascular stability.\n9. Maximal inspiratory pressure from 15 to 30 cm H2O and able to trigger spontaneous breaths on ventilator.\n\nExclusion Criteria:\n\n1. Persistent hemodynamic instability as life threatening arrhythmias, acute heart failure.\n2. Severe breathlessness, when spontaneously breathing.\n3. Any progressive neuromuscular disease that would interfere with responding to inspiratory muscle training (non-stationary course).\n4. Spinal cord injury.\n5. Skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs.\n6. Patients on heavy sedation and respiratory muscle paralysis.\n7. High peak airway pressure (barotraumas).\n8. BMI ≥ 40.","ALL","20 Years","55 Years",{"count":68,"type":69},45,"ESTIMATED","INTERVENTIONAL",[72],"NA","The aim of the current study is to compare the effect of ventilator trigger sensitivity adjustment versus threshold inspiratory muscle training on arterial blood gases in mechanically ventilated patients.",[75],"Guillain-Barre Syndrome","2024-12-16",{"date":78,"type":79},"2024-12-17","ACTUAL",{"date":81,"type":79},"2023-05-02",{"date":83,"type":69},"2024-12",{"name":5,"class":6},1]