[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100505866":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":28,"locations":34,"responsibleParty":53,"collaborators":55,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":81,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Tufts Medical Center","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Post-Acute Sequelae of SARS-CoV-2 (PASC) Group",null,"Subjects with PASC with a documented history of COVID-19 and persistent symptoms of fatigue, dyspnea, and\u002For exercise intolerance",[13],"Diagnostic Test: Computed Tomography of the Chest",{"label":15,"type":10,"description":16,"interventionNames":17},"Control: Fully recovered COVID-19","Subjects with a history of COVID-19 who have fully recovered from COVID-19 with no post-acute sequelae of SARS-Cov-2",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Control: No history of COVID-19","Healthy subjects without a documented history of COVID-19, no current symptoms, and a normal baseline High resolution CT of the chest",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DIAGNOSTIC_TEST","Computed Tomography of the Chest","Quantitative Computed Tomography of the chest in the inspiratory and expiratory phases will be performed to assess regional lung ventilation as well as pulmonary vascular volume and distribution",[15,19,9],[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Bipin Malla","CONTACT","617-636-6304","tuftsmccorstudy@tuftsmedicalcenter.org",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Boston","Massachusetts","02111","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-71.05977,42.35843,{"lat":46,"lon":45},[49,50],{"name":30,"role":31,"phone":10,"phoneExt":10,"email":10},{"name":51,"role":52,"phone":10,"phoneExt":10,"email":10},"Maher Ghamloush, MD","PRINCIPAL_INVESTIGATOR",{"type":54,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[56],{"name":57,"class":58},"4DMedical","INDUSTRY","100505866","ventilatory-and-perfusion-abnormalities-in-individuals-with-post-acute-sequelae-of-sars-cov-2-infection-100505866",false,"NCT05866952","Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection","Quantitative Computed Tomography to Assess Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection","PASC VQ","Inclusion Criteria:\n\n* Age ≥ 18\n* Self-reported or documented SARS-CoV-2 infection by RT-PCR or Antigen testing \\> 3 months ago or no previous history of SARS-CoV-2 infection (control group only)\n* Normal or mild abnormalities on baseline Pulmonary Function Tests (PFTs)\n* New or worsening symptoms of chronic fatigue, dyspnea or exercise intolerance after COVID-19 with otherwise unclear etiology (PASC group only)\n\nExclusion Criteria:\n\n* SARS-CoV-2 infection by RT-PCR or Antigen testing within the last 3 months\n* Inability to provide consent or non-English speaking\n* Pregnancy\n* Any respiratory infection in last 4 weeks\n* PFT relative contraindications\n* History of major cardiovascular, pulmonary, renal, hepatic, autoimmune or neuromuscular disease including asthma, COPD, interstitial lung disease, heart failure, pulmonary arterial hypertension, or prior pulmonary embolism\n* Active malignancy undergoing treatment or history of malignancy involving the lung",true,"ALL","18 Years","99 Years",{"count":72,"type":73},40,"ESTIMATED","OBSERVATIONAL","Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations",[77,78,79,80],"Post-Acute COVID-19","Post COVID-19 Condition","Post Viral Fatigue","Dyspnea",[82],"Ventilation Perfusion Mismatch","2025-07-16",{"date":85,"type":86},"2025-07-20","ACTUAL",{"date":88,"type":86},"2023-06-05",{"date":90,"type":73},"2026-12-31",{"name":5,"class":6},1]