[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535717":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":10,"locations":20,"responsibleParty":43,"collaborators":46,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":10,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":23,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Karolinska Institutet","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Arrhythmogenic mitral valve prolapse versus non-arrhythmogenic mitral valve prolapse",null,"Surgical repair or replacement of the mitral valve due to significant mitral regurgitation according to standard of care.",[13],"Procedure: Mitral valve surgery",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Mitral valve surgery","Mitral valve repair or replacement of mitral regurgitation",[9],[21],{"facility":22,"status":23,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Karolinska Univeristy Hospital","RECRUITING","Stockholm","Stockholm County","171 76","Sweden","SE",{"type":30,"coordinates":31},"Point",[32,33],18.06871,59.32938,{"lat":33,"lon":32},[36,41],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Bahira Shahim, MD, PhD","CONTACT","+46705347350","bahira.shahim@ki.se",{"name":37,"role":42,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":42,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Bahira Shahim","Assistant professor",[47],{"name":48,"class":6},"Karolinska University Hospital","100535717","ventricular-arrhythmias-in-patients-undergoing-mitral-valve-surgery-100535717",false,"NCT06255457","Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery","Mechanisms and Outcomes in Patients With Arrhythmic Mitral Valve Prolapse Undergoing Mitral Valve Surgery","Mitra-VT","Inclusion criteria\n\n* Age 18 and over\n* Patients with and without (controls) arrhythmogenic MVP in need of mitral valve surgery for primary mitral regurgitation according to current standard of care\n\nExclusion criteria\n\n* Secondary mitral regurgitation\n* Primary mitral regurgitation not due to degenerative disease (including rheumatic disease)\n* Co-existing moderate or severe aortic valve disease\n* Congenital heart disease\n* Inherited or acquired cardiomyopathy\n* Non-incidental or symptomatic coronary artery disease\n* Uncontrolled atrial fibrillation (resting heart rate \\> 100\u002Fmin)\n* Pregnancy\n* Unable to undergo CMR","ALL","18 Years",{"count":60,"type":61},90,"ESTIMATED","OBSERVATIONAL","Study objectives:\n\n* To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in patients with arrhytmogenic mitral valve prolapse (MVP) from baseline to 6 months after surgery\n* To characterize the molecular landscape of arrhytmogenic MVP\n\nStudy design:\n\n-Prospective explorative observational study\n\nStudy population:\n\n-90 patients with arrhytmogenic MVP and without arrhytmogenic MVP (controls) eligible for mitral valve surgery for mitral regurgitation will be enrolled. All patients will be evaluated with cardiac magnetic resonance (CMR) imaging and continuous seven day arrhythmic monitoring before and at 6 months after mitral valve surgery",[65,66,67],"Mitral Regurgitation","Mitral Valve Prolapse","Ventricular Tachycardia","2025-09-04",{"date":70,"type":71},"2025-09-11","ACTUAL",{"date":73,"type":71},"2024-02-21",{"date":75,"type":61},"2026-03-01",{"name":5,"class":6},1]