[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563958":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":30,"responsibleParty":45,"collaborators":47,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":76,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Nazarbayev University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"End-Stage Renal Disease Patients on Hemodialysis",null,"Patients with end-stage renal disease (ESRD) undergoing regular hemodialysis, recruited based on specific inclusion and exclusion criteria. Inclusion criteria include patients aged 18 or older, receiving a standard renal replacement therapy of three dialysis sessions per week, with a dialysis history of at least 3 months and dialysis adequacy (Kt\u002FV \\>1.2). Exclusion criteria include patients with a history of kidney transplantation, recent myocardial infarction or stroke, severe heart failure, chronic atrial fibrillation, obesity (BMI \\>40 kg\u002Fm²), and malignancy.\n\nPatients will undergo echocardiographic evaluations before and after dialysis, with a focus on left ventricular function and ventriculo-arterial coupling (VAC) using speckle-tracking echocardiography and pressure-volume loop analysis.",[13],"Diagnostic Test: Echocardiogram",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Echocardiogram","Echocardiographic Assessments:\n\nPre-Hemodialysis Echocardiography:\n\nBefore each hemodialysis session, echocardiograms will be performed to evaluate cardiac function and gather baseline data on ventriculo-arterial coupling (VAC) parameters. This will include recording three apical echocardiographic views (4-chamber, 2-chamber, and 3-chamber) by a trained sonographer.\n\nPost-Hemodialysis Echocardiography:\n\nFollowing the completion of the hemodialysis session, echocardiographic assessments will be repeated to measure changes in VAC parameters and other relevant cardiac metrics.",[9],[21],{"name":22,"affiliation":23,"role":24},"Alessandro Salustri, MD, PhD","Nazarbayev University School of Medicine","PRINCIPAL_INVESTIGATOR",[26],{"name":22,"role":27,"phone":28,"phoneExt":10,"email":29},"CONTACT","+ 39 339 360 9520","alessandro.salustri@nu.edu.kz",[31],{"facility":23,"status":10,"city":32,"state":10,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Astana","010000","Kazakhstan","KZ",{"type":37,"coordinates":38},"Point",[39,40],71.44598,51.1801,{"lat":40,"lon":39},[43],{"name":22,"role":27,"phone":44,"phoneExt":10,"email":29},"+39 339 360 9520",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[48,51],{"name":49,"class":50},"B.B.NURA, Center of efferent therapy and hemodialysis in Astana","UNKNOWN",{"name":52,"class":50},"JSC National Research Cardiac Surgery Center","100563958","ventriculo-arterial-coupling-and-intra-dialytic-changes-in-hemodialysis-patients-prognostic-insights-100563958",false,"NCT06622928","Ventriculo-Arterial Coupling and Intra-Dialytic Changes in Hemodialysis Patients: Prognostic Insights","Ventriculo-arterial Coupling in Patients With End-stage Renal Disease on Hemodyalisis: Intra-dialytic Changes and Prognostic Value.","Inclusion Criteria:\n\n* 18 years or older;\n* Standard renal replacement schedule with 3 dialysis sessions per week;\n* Dialysis vintage of at least 3 months;\n* Dialysis adequacy with single-pool Kt\u002FV \\>1.2\n\nExclusion Criteria:\n\n* Previous kidney transplantation\n* Myocardial infarction, unstable angina or stroke during the previous 6 months;\n* Severe stage III to IV congestive heart failure according to the NYHA classification;\n* Chronic atrial fibrillation or other known arrhythmia;\n* History of non-adherence to the prescribed weekly dialysis schedule in the previous month;\n* Body mass index \\>40 Kg\u002Fm2; or\n* History of malignancy or other clinical conditions associated with very poor prognosis.","ALL","18 Years",{"count":63,"type":64},384,"ESTIMATED","OBSERVATIONAL","The acute effect of hemodialysis (HD) on left ventricular mechanics has been evaluated in several studies, however their results are not uniform. Eventually, the heart and the arterial system behave as an interconnected system and not as isolated structures; thus, the evaluation of the interaction of cardiac contractility with the arterial system would provide a more comprehensive understanding of the cardiovascular function and cardiac energetics. However, there have not been any studies demonstrating changes in terms of volumes, contractility, intraventricular pressure gradients distribution, and vascular properties in response to changes in loading conditions and their impact on the outcome.\n\nWith these concepts in mind, we aim to evaluate the effect of volume changes induced by HD on ventriculo-arterial coupling (VAC) computed from speckle-tracking echocardiography. In particular, we seek to study patients with end-stage renal disease (ESRD) to assess:\n\n1. VAC parameters before and after the hemodialysis session;\n2. The value of VAC parameters in predicting adverse outcome\n\nThree-hundred-eighty-four patients with ESRD will be evaluated by standard 2-D echocardiography before and after the HD session. Echocardiographic speckle tracking images will be analysed off-line using a dedicated software based on a mathematical model (QStrain, Medis BV, Leiden, NL). The software reconstructs the pressure\u002Fvolume (PV) loop by determining the end-systolic and end-diastolic pressure-volume relationship using the single-beat algorithms. The PV relation will be depicted for the entire cardiac cycle where each point of the curve is described as (Vt, Pt). Based on this integrated PV loop analysis, the following hemodynamic parameters will be calculated: LV systolic elastance (Ees); Arterial elastance (Ea); Ventricular-Arterial Coupling (VAC); Stroke Work (SW); Pressure-volume area (PVA); Work efficiency (WE).\n\nPatients will be followed-up for 18 months. Primary end-point will be a composite of all-cause of death, nonfatal myocardial infarction, and hospitalization due to worsening heart failure. Secondary end-point will be a composite of cardiac death, nonfatal myocardial infarction, and hospitalization for heart failure. Event-free survival for each of the echocardiographic and VAC parameters will be assessed using Kaplan-Meier analysis and compared with a log-rank test, where each index will be dichotomized according to the median of its distribution. The prognostic value will be determined using the Cox proportional hazards model. Differences will be considered statistically significant when p \\<0.05.",[68,69],"Hemodialysis","Ventriculo-arterial Coupling",[71,72,73,74,75],"hemodialysis","end-stage renal disease","ventriculo-arterial coupling","advanced echocardiography","cardiac ultrasound","NOT_YET_RECRUITING","2024-09-29",{"date":79,"type":80},"2024-10-02","ACTUAL",{"date":82,"type":64},"2024-10-01",{"date":84,"type":64},"2026-11-01",{"name":5,"class":6},1]