[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622196":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":12,"locations":18,"responsibleParty":32,"collaborators":7,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":38,"sex":44,"minAge":45,"maxAge":7,"enrollmentInfo":46,"targetDuration":49,"studyType":50,"phases":7,"briefSummary":51,"conditions":52,"keywords":7,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},{"fullName":5,"class":6},"Rigshospitalet, Denmark","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"Sampling of blood and cerebrospinal fluid","As soon as possible after placement of the external drain, and then in intervals of 1-3 days;\n\n* CSF analyses: cerebrospinal fluid group analysis (eosinophilic granulocytes, erythrocytes, glucose, nucleated cells, leucocytes (mononuclear), lymphocytes, macrophages, monocytes, neutrophil granulocytes, protein, and smudge cells) and lactate (L-lactate and D-lactate). Analyses will be performed by the Dept. of Biochemistry, Rigshospitalet, Denmark.\n* CSF microscopy and culture: Analysed by the Dept. of Microbiology, Rigshospitalet, Denmark.\n* Blood: C-reactive protein, differentials (leukocytes, neutrophile granulocytes, erythrocytes, lymphocytes). Analyses will be performed by the Dept. of Biochemistry, Rigshospitalet, Denmark.\n* Blood: lactate and glucose. Point of care (POC) analysis by blood gas analyser (Radiometer ABL800 Series Flex Q, Denmark)",[13],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Pernille Nielsen, Medical doctor","CONTACT","+45 22220775","pernille.nielsen.05@regionh.dk",[19],{"facility":20,"status":21,"city":22,"state":7,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":7},"Rigshospitalet","RECRUITING","Copenhagen","2100","Denmark","DK",{"type":27,"coordinates":28},"Point",[29,30],12.56553,55.67594,{"lat":30,"lon":29},{"type":33,"investigatorFullName":34,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Pernille Rosenfeldt","MD, PhD-student","100622196","ventriculostomy-associated-infections-lactic-focus-on-csf-lactate-and-sampling-site-100622196",false,"NCT07380477","VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site","CSF Lactate and Ventriculostomy Associated Infections in Patients With Acute Brain Injury - a Prospective, Observational Cohort Study.","LACTIC","Inclusion Criteria:\n\n* Age \\>18 years\n* EVD in situ\n* Admission to the neuro-ICU or neurosurgical step-down unit at Rigshospitalet, Denmark\n* Diagnosis of acute brain injury categorized as traumatic brain injury, subarachnoid haemorrhage, intracranial haemorrage, intraventricular haemorrhage\n\nExclusion Criteria:\n\n* Patient or closest relatives do not understand written and spoken Danish or English\n* Patients transferred to Rigshospitalet with an EVD\n* Patients with brain injury due to existing brain infection (e.g., meningitis, intracranial empyema or abscess, encephalitis)\n* Patients with existing ventriculoperitoneal or ventriculoatrial shunt at the time of admission\n* Patients with primary or secondary brain cancer\n* Patients died or in palliative care","ALL","18 Years",{"count":47,"type":48},148,"ESTIMATED","6 Months","OBSERVATIONAL","This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to:\n\n1. investigate various biomarkers, with a primary focus on the development of cerebrospinal fluid lactate in relation to ventriculostomy-associated infection;\n2. compare proximal and distal sample results obtained from an external ventricular drain;\n3. describe the natural progression of various biomarkers in blood and cerebrospinal fluid following acute brain injury.",[53,54,55,56],"Acute Brain Injury","Hydrocephalus","External Ventricular Drain","External Ventricular Drainage Associated Infection","2026-01-28",{"date":59,"type":60},"2026-02-02","ACTUAL",{"date":62,"type":60},"2025-01-15",{"date":64,"type":48},"2029-10-01",{"name":5,"class":6},1]