[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100493350":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":29,"responsibleParty":46,"collaborators":50,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":19,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":19,"enrollmentInfo":68,"targetDuration":19,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":83,"overallStatus":32,"whyStopped":19,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"San Raffaele University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Lynch Syndrome","EXPERIMENTAL","Video capsule endoscopy every 2 years",[13],"Device: Video capsule endoscopy",[15],{"type":16,"name":17,"description":11,"armGroupLabels":18,"otherNames":19},"DEVICE","Video capsule endoscopy",[9],null,[21,26],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Giulia Martina Cavestro, MD PhD","CONTACT","+390226437217","cavestro.giuliamartina@hsr.it",{"name":27,"role":23,"phone":24,"phoneExt":19,"email":28},"Marta Puzzono, MD","puzzono.marta@hsr.it",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"San Raffaele Scientific Institute, Gastroenterology and Gastrointestinal Endoscopy Unit","RECRUITING","Milan","Lombardy","20132","Italy","IT",{"type":39,"coordinates":40},"Point",[41,42],9.18951,45.46427,{"lat":42,"lon":41},[45],{"name":22,"role":23,"phone":19,"phoneExt":19,"email":25},{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","Cavestro Giulia Martina MD PhD","Prof Cavestro Giulia Martina",[51,54,56],{"name":52,"class":53},"Unita' di Gastroenterologia - Policlinico Universitario di Bari","UNKNOWN",{"name":55,"class":6},"Centro di Riferimento Oncologico - Aviano",{"name":57,"class":6},"Humanitas Hospital, Italy","100493350","videocapsule-endoscopy-in-lynch-syndrome-100493350",false,"NCT05704010","Videocapsule Endoscopy in Lynch Syndrome","Role of Videocapsule Endoscopy in Lynch Syndrome: a Multicenter Italian Registry Study","Inclusion Criteria:\n\n* Pathogenic germline variant in one of the MMR genes (MLH1, MSH2\u002FEpcam, MSH6, or PMS2).\n\nExclusion Criteria:\n\n* Patients younger than 18 years of age\n* Patients unwilling or unable to provide informed consent\n* Patients with prior small bowel surgery\n* Patients with a contraindication to VCE",true,"ALL","18 Years",{"count":69,"type":70},100,"ESTIMATED","INTERVENTIONAL",[73],"NA","Background Lynch syndrome is caused by a pathogenic variant in one of the four Mismatch Repair genes (MMR): MLH1, MSH2\u002FEpcam, MSH6, or PMS2. These pathogenic variants confer a higher risk of developing colorectal and other cancers, including small bowel cancer. The risk of developing a small bowel adenocarcinoma is about 100 times higher compared to individuals without Lynch syndrome, and the lifetime risk of small bowel cancer is estimated at 4,2%.\n\nThe diagnosis of a small bowel cancer depends on videocapsule endoscopy (VCE). This device is swalled so that it can record images of the small bowel, which are then stored on a wearable device for about 8 hours. The capsule is then expelled in the feces while the images are transferred to a computer to be analysed. To date, there is conflicting evidence on the efficacy of small bowel cancer screening with VCE\n\nRationale: this registry study will collect prospective data from patients with LS undergoing VCE\n\nAim: evaluate the incidence of neoplastic and pre-neoplastic lesions in patients with LS during a VCE-based small bowel cancer screening study\n\nDesign: this is a multicentric, observational study that analyzes data from diagnostic techniques already approved. Patients will not undergo diagnostic procedures beyond what would be recommended by clinical practice.",[9,76,77,78,79,80,81,82],"Lynch Syndrome I","Lynch Syndrome II","MLH1 Gene Mutation","MSH2 Gene Mutation","MSH6 Gene Mutation","PMS2 Gene Mutation","Small Bowel Adenocarcinoma",[84,85],"Videocapsule","Small bowel","2026-04-21",{"date":88,"type":89},"2026-04-22","ACTUAL",{"date":91,"type":89},"2018-11-01",{"date":93,"type":70},"2029-12-31",{"name":5,"class":6},1]