[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591876":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":21,"centralContacts":26,"locations":35,"responsibleParty":53,"collaborators":21,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":21,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":38,"whyStopped":21,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Trustees of Dartmouth College","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Contextual learning","EXPERIMENTAL","All participants complete trials in three virtual contexts (safe, controllable threat, uncontrollable threat), with pain controllability and task performance assessed across all conditions in a randomized within-subject design.",[13,14],"Behavioral: Pain Threat Manipulation","Behavioral: Pain Controllability Manipulation",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"BEHAVIORAL","Pain Threat Manipulation","Participants receive brief thermal pain stimuli in certain virtual environments to examine how threat influences perception and physiological responses.",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"Pain Controllability Manipulation","In some contexts, participants can reduce or avoid pain using a button; in others, no action changes the outcome. This manipulation is used to study the effects of perceived control over pain.",[9],[27,32],{"name":28,"role":29,"phone":30,"phoneExt":21,"email":31},"Tor D Wager, PhD","CONTACT","3038958739","tor.d.wager@dartmouth.edu",{"name":33,"role":29,"phone":21,"phoneExt":21,"email":34},"Vivek Sagar, PhD","vivek.sagar@dartmouth.edu",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Dartmouth College","RECRUITING","Hanover","New Hampshire","03755","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-72.28954,43.70229,{"lat":48,"lon":47},[51],{"name":52,"role":29,"phone":21,"phoneExt":21,"email":21},"Sydney Shohan",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"PRINCIPAL_INVESTIGATOR","Tor Wager","Diana L. Taylor Distinguished Professor in Neuroscience","100591876","virtual-contexts-for-affective-modulation-100591876",false,"NCT06986122","Virtual Contexts for Affective Modulation","Controllability of Virtual Contexts for the Modulation of the Affective Experience","VCAM","* No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis\n* No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis\n* No self-reported current chronic pain, or acute pain within three months of the study period\n* No current migraine disorder (i.e., 15 headache days or more in 1 month)\n* No use of central nervous system-effective medication or other medication for neurological\u002Fpsychiatric treatment\n* No self-reported substance abuse within the last six months\n* No contraindication to MRI (e.g., pregnancy, claustrophobia, pacemakers, ear\u002Fcochlear implants, shrapnel injuries, clips, or other ferromagnetic\u002Felectrical objects\u002Fdevices, diagnosed brain abnormality such as tumor, or skin lesions on the scalp.)\n* No contraindications for induced pain (e.g., no heart disease, high blood pressure, heart surgery, heart problems of any kind, severe asthma, respiratory problems of any kind, fibromyalgia, Raynaud's Syndrome or Disease, chronic pain, diabetes)\n* Participants must be capable of performing experimental tasks (e.g., are able to read), are fluent or native speakers of English\n* Participants must be able to tolerate the maximum level of thermal pain stimuli (for thermal stimuli)",true,"ALL","18 Years","55 Years",{"count":70,"type":71},20,"ESTIMATED","INTERVENTIONAL",[74],"NA","This study investigates how spatial context and perceived controllability modulate pain, affective states such as anxiety, and motivated behavior. The study examines how control over pain and threat-related environments influences pain perception, state anxiety, associated autonomic responses, and behavior. The main questions it aims to answer are:\n\nDoes having control over pain within specific contexts alter how much pain people feel-even when the stimulus intensity remains constant? How do different types of environments (safe, controllable, or uncontrollable) shape pain-related brain activity, subjective anxiety, and physiological arousal? How do people perform cognitively demanding or distracting tasks (and retain their memory) when under threat versus when in control? Lastly, how do these learned associations with spatial contexts persist or adapt when environmental contingencies are explicitly changed?\n\nTaken together, exploration of these factors may lay the groundwork for understanding how placebo-related mechanisms-including perceived control, contextual learning, emotional engagement, and distraction-interact to shape pain and anxiety in complex environments.",[77,78,79],"Pain Control","Anxiety","Memory",[81,82],"Place conditioning","controllability of pain","2025-10-29",{"date":85,"type":86},"2025-10-31","ACTUAL",{"date":88,"type":86},"2025-10-28",{"date":90,"type":71},"2029-06-15",{"name":5,"class":6},1]