[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599844":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":52,"collaborators":56,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":26,"eligibilityCriteria":79,"healthyVolunteers":76,"sex":80,"minAge":81,"maxAge":26,"enrollmentInfo":82,"targetDuration":26,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":94,"overallStatus":99,"whyStopped":26,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Region Stockholm","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Virtual Chromoendoscopy (VCE) Group","EXPERIMENTAL","Participants randomized to this arm will undergo surveillance colonoscopy using high-definition virtual chromoendoscopy. This technique enhances mucosal visualization through advanced imaging technology without the use of dyes. The colonoscope's built-in virtual chromoendoscopy mode will be used to detect and characterize dysplastic lesions during withdrawal.",[13],"Procedure: Virtual Chromoendoscopy",{"label":15,"type":16,"description":17,"interventionNames":18},"Dye-Based Chromoendoscopy (DCE) Group","ACTIVE_COMPARATOR","Participants randomized to this arm will undergo surveillance colonoscopy using high-definition dye-based chromoendoscopy. Indigo carmine dye will be sprayed segmentally on the colonic mucosa via a dye spray catheter to enhance visualization of mucosal patterns and detect dysplasia. Targeted biopsies will be taken from suspicious areas identified with dye staining.",[19],"Procedure: Dye-Based Chromoendoscopy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Virtual Chromoendoscopy","High-Definition Virtual Chromoendoscopy (HD-VCE):\n\nSurveillance colonoscopy using high-definition virtual chromoendoscopy enhances mucosal visualization through advanced imaging filters integrated into the colonoscope. This dye-free technique improves detection of dysplasia by increasing contrast and highlighting subtle mucosal patterns during withdrawal. HD-VCE reduces procedure time and eliminates risks related to dye application, offering a practical alternative to dye-based methods. Its efficacy in IBD surveillance requires further validation.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Dye-Based Chromoendoscopy","High-Definition Dye-Based Chromoendoscopy (HD-DCE):\n\nSurveillance colonoscopy using high-definition dye-based chromoendoscopy involves segmental application of indigo carmine dye via a spray catheter. The dye enhances mucosal surface patterns, aiding dysplasia detection. HD-DCE is currently considered a gold standard in IBD surveillance due to superior dysplasia detection rates.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Olga Bednarska, MD PhD","CONTACT","0046703980931","olga.bednarska@regionstockholm.se",[38],{"facility":39,"status":26,"city":40,"state":26,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Karolinska University Hospital","Stockholm","141 57","Sweden","SE",{"type":45,"coordinates":46},"Point",[47,48],18.06871,59.32938,{"lat":48,"lon":47},[51],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":39,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Olga Bednarska","Principal Investigator",[57,60,62,64,65,67,69,72],{"name":58,"class":59},"Uppsala University Hospital","OTHER",{"name":61,"class":59},"Sahlgrenska University Hospital",{"name":63,"class":59},"Falu Hospital",{"name":39,"class":59},{"name":66,"class":59},"Örebro University, Sweden",{"name":68,"class":59},"Ersta Diakoni",{"name":70,"class":71},"Saint Göran Hospital","UNKNOWN",{"name":73,"class":59},"University Hospital, Linkoeping","100599844","virtual-versus-dye-based-chromoendoscopy-in-inflammatory-bowel-disease-surveillance-colonoscopy-100599844",false,"NCT07089771","Virtual Versus Dye-based Chromoendoscopy in Inflammatory Bowel Disease Surveillance Colonoscopy","Inclusion Criteria:\n\n* Age ≥ 18 years and one of the criteria beneath:\n* Extensive ulcerative colitis or indeterminate colitis (IBD-U), or Crohn's colitis involving at least one-third of the colon, with a disease history of at least 8 years\n* IBD or IBD-U with primary sclerosing cholangitis (PSC)\n* IBD or IBD-U with a family history of colorectal cancer in a first-degree relative\n\nExclusion Criteria:\n\n* History of colorectal cancer or prior colectomy\n* Contraindications to dye use\n* Colonoscopies for therapeutic purposes\n* Pregnancy\n* Inability to consent","ALL","18 Years",{"count":83,"type":84},480,"ESTIMATED","INTERVENTIONAL",[87],"NA","People with inflammatory bowel disease (IBD), such as ulcerative colitis or Crohn's disease affecting the colon, have a higher risk of developing colon cancer over time. To catch early signs of cancer, regular colonoscopies are recommended. In this study, the investigators are comparing two advanced methods of examining the colon during these surveillance colonoscopies. One method uses a special dye sprayed inside the colon to highlight abnormal areas (called dye-based chromoendoscopy). The other method uses new technology built into the camera to enhance the view without needing any dye (called virtual chromoendoscopy). Both methods use modern, high-definition equipment.\n\nThe purpose of this study is to find out if the newer, dye-free method is as good as the traditional dye method at detecting pre-cancerous changes (called dysplasia) in people with IBD.\n\nAdults with IBD who are due for a routine surveillance colonoscopy may be invited to take part. Participants will be randomly assigned to one of the two methods. No additional procedures are involved, and only the way the colon is viewed differs. The investigators will also look at how long the procedures take, how many biopsies are needed, any complications, and how patients experience the exam. Participants will be followed over time using national health records to check for long-term outcomes.\n\nThis research will help doctors better understand which method is most effective and comfortable for patients, and may guide future recommendations for cancer screening in people with IBD.",[90,91,92,93],"Inflammatory Bowel Disease (IBD)","Ulcerative Colitis (Disorder)","Crohns Disease","Colorectal Neoplasms",[95,96,97,98],"virtual chromoendoscopy","dye-based chromoendoscopy","dysplasia detection","IBD surveillance colonoscopy","NOT_YET_RECRUITING","2026-03-18",{"date":102,"type":103},"2026-03-20","ACTUAL",{"date":105,"type":84},"2026-05-01",{"date":107,"type":84},"2032-12-31",{"name":5,"class":6},1]