[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637773":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":30,"responsibleParty":49,"collaborators":51,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":20,"eligibilityCriteria":62,"healthyVolunteers":59,"sex":63,"minAge":64,"maxAge":20,"enrollmentInfo":65,"targetDuration":20,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":20,"overallStatus":32,"whyStopped":20,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"New England College of Optometry","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Feedback Training","EXPERIMENTAL","All participants will receive binocular oculomotor training with multimodal feedback. Participants will complete 5 weekly training sessions (approximately 60 minutes each) performing saccadic and smooth pursuit eye movement exercises. Training incorporates three types of feedback presented systematically across sessions: (1) scotoma awareness feedback via gaze-contingent black circle overlay representing the blind spot, (2) preferred retinal locus (PRL) feedback via dynamic gaze-contingent ring showing real-time fixation location, and (3) auditory feedback with tone modulation indicating fixation stability, PRL accuracy, and target acquisition. Eye movements are recorded using binocular eye tracking at 2000Hz. Contrast sensitivity is assessed intermittently during training using adaptive Gabor presentations. Outcomes are measured at baseline (Week 0) and post-training (Week 6).",[13],"Behavioral: eccentric viewing training with biofeedback",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","eccentric viewing training with biofeedback","Participants will complete 5 weekly training sessions (approximately 60 minutes each) performing eye movement exercises while receiving real-time multimodal feedback. Training includes:\n\nSaccadic Training: Visually-guided saccades to targets appearing at randomized locations with instructions to use peripheral (inferior) retinal locus. Targets shift horizontally, vertically, and obliquely to train all saccadic directions.\n\nSmooth Pursuit Training: Circular pursuit of moving targets at 2.6°\u002Fs in randomized directions with instructions to maintain peripheral gaze above the target.\n\nFeedback Modalities (systematically varied across sessions):Scotoma Awareness: Gaze-contingent black circle overlay representing participant's blind spot; Preferred Retinal Locus (PRL) Feedback: Dynamic gaze-contingent ring showing real-time fixation location; Auditory Feedback: Tone modulation indicating fixation stability, PRL accuracy, and target acquisition success; Combined multimodal feedback",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Nicole C Ross, OD","CONTACT","6175875626","rossn@neco.edu",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},"Cecilia Idman-Rait, MPH","idmanraitc@neco.edu",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Boston","Massachusetts","02115","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-71.05977,42.35843,{"lat":42,"lon":41},[45,48],{"name":46,"role":24,"phone":47,"phoneExt":20,"email":26},"Nicole C Ross, OD, MSc.","617-587-5626",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},{"type":50,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[52,55],{"name":53,"class":54},"H. Eric Cushing Foundation","UNKNOWN",{"name":56,"class":54},"Northeastern University, Department of Psychology","100637773","vision-rehabilitation-training-with-multimodal-feedback-in-central-vision-loss-100637773",false,"NCT07577219","Vision Rehabilitation Training With Multimodal Feedback in Central Vision Loss","Inclusion Criteria:\n\nBilateral central scotomas confirmed via computerized tangent screen Visual acuity between 20\u002F60 and 20\u002F200 (0.5 - 1.00 logMAR) in either eye Stable central vision loss (no change in visual acuity \\>0.2 logMAR in past 6 months) Age 14 years or older, with diagnosis of macular disease Normal cognitive function (Mini-Mental State Examination score ≥24) Ability to provide informed consent and complete study visits No major hearing loss Fluent in English\n\nExclusion Criteria:\n\nUnstable ocular disease (e.g., ongoing treatments and\u002For injections) Peripheral vision loss of less than 40 degrees Conditions affecting oculomotor control independent of CVL","ALL","14 Years",{"count":66,"type":67},12,"ESTIMATED","INTERVENTIONAL",[70],"NA","Central vision loss from macular degeneration creates blind spots that impair reading, face recognition, and navigation. Individuals must learn to use peripheral vision, requiring retraining of eye movements. Our preliminary research using high-speed eye tracking demonstrated that people with larger scotomas have impaired eye movement control, and that single-session visual feedback training showed limited immediate benefit, though combining feedback types showed promise.\n\nThis study will evaluate whether extended binocular training (5 weekly sessions) with multimodal feedback improves eye movement control in 8-15 participants with bilateral central vision loss. Unlike conventional monocular rehabilitation systems, our approach trains both eyes simultaneously using real-time visual and auditory feedback during saccadic and smooth pursuit tasks. Participants will receive gaze-contingent scotoma awareness feedback, preferred retinal locus feedback, and auditory cues while performing eye tracking exercises.\n\nPrimary outcomes include saccadic accuracy (latency, landing error, amplitude) and smooth pursuit parameters (gain, tracking accuracy). Secondary outcomes include contrast sensitivity and self-reported visual function. Success could establish an evidence base for accessible home-based training using virtual reality technology, potentially benefiting millions with macular degeneration.",[73,74,75],"Low Vision","Central Visual Impairment","Macular Degeneration","2026-05-05",{"date":78,"type":79},"2026-05-11","ACTUAL",{"date":81,"type":79},"2026-01-31",{"date":83,"type":67},"2026-12-01",{"name":5,"class":6},1]